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公开(公告)号：EP1378749A4
公开(公告)日：2005-05-11
申请号：EP02717114
申请日：2002-04-11
发明人： HINUMA SYUJI , FUJII RYO , KAWAMATA YUJI , MIWA MASANORI , HOSOYA MASAKI
IPC分类号： C07K14/705 , C07K14/72 , C12N1/15 , C12N1/19 , C12N1/21 , G01N33/566 , G01N33/58 , G01N33/74 , G01N33/92 , G01N33/50 , C07K16/28 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15
CPC分类号： G01N33/74 , C07K14/705 , C07K14/723 , G01N33/566 , G01N33/582 , G01N33/92
摘要： It is intended to provide a method of screening an agonist/an antagonist, etc. More specifically, a method of screening a compound capable of changing the binding properties of a novel G protein-coupled receptor protein, which has an amino acid sequence the same or substantially the same as an amino acid sequence represented by any of SEQ ID NOS:1, 5, 7, 14 and 16, or its salt to a compound relating to choleresterol metabolism characterized by using the receptor protein or its salt and the compound relating to cholesterol metabolism, etc. are provided.
摘要翻译： 它的目的是提供筛选激动剂/拮抗剂等更具体地，筛选能够改变的新的G蛋白偶联受体蛋白质，其具有的氨基酸序列的结合特性的化合物的方法的方法中的相同 或基本相同的由任一SEQ ID NOS的表示的氨基酸序列：1，5，7，14和16，或它的盐与choleresterol代谢特征在于使用受体蛋白或其盐和有关的化合物的化合物 提供胆固醇代谢等。
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公开(公告)号：EP1743944A4
公开(公告)日：2011-01-05
申请号：EP05736916
申请日：2005-04-22
发明人： FUJII RYO , NISHI KAZUNORI , TANAKA YASUHIRO , MORI MASAAKI
IPC分类号： C12Q1/02 , A61K45/00 , A61P1/00 , A61P1/08 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , A61P33/12 , A61P37/02 , A61P37/06 , C12N15/09 , G01N33/15 , G01N33/50 , G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/00 , Y10S435/975
摘要： The present invention relates to screening of an agonist/antagonist, etc. Specifically, the present invention provides a method of screening an agonist or antagonist of a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and a cholesterol metabolism-related substance, and so on.
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公开(公告)号：EP1617216A4
公开(公告)日：2007-03-21
申请号：EP04728959
申请日：2004-04-22
发明人： KOBAYASHI MAKOTO , HABATA YUGO , FUJII RYO , HINUMA SHUJI
IPC分类号： G01N33/50 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/06 , A61P19/02 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/00 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/72 , C12Q1/02 , G01N33/15 , G01N33/74
CPC分类号： G01N33/74 , A61K38/177 , G01N2333/726 , G01N2500/04
摘要： The use of a G-protein conjugated receptor protein containing an amino acid sequence identical with or substantially identical with the amino acid sequence of SEQ ID No. 1 or a salt thereof and a ligand peptide containing an amino acid sequence represented by any of SEQ ID Nos. 3 to 7 or a salt thereof enables efficient screening of an agonist or antagonist for the above receptor protein or salt thereof.
摘要翻译： 含有与SEQ ID No.1的氨基酸序列相同或基本上相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和含有SEQ ID No.1中任一氨基酸序列的配体肽的用途， No.3-7或其盐能够有效筛选上述受体蛋白质或其盐的激动剂或拮抗剂。
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公开(公告)号：EP1619499A4
公开(公告)日：2008-03-05
申请号：EP04729276
申请日：2004-04-23
发明人： ITO YASUAKI , FUJII RYO , KOBAYASHI MAKOTO , HINUMA SHUJI , HASHIMOTO TADATOSHI , TANAKA YASUHIRO
CPC分类号： G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
摘要： By using a G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same as the amino aid sequence represented by SEQ ID NO:1 or its salt and an ion chemically available metal element or its salt, an agonist or an antagonist to the above receptor protein or its salt can be efficiently screened.
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公开(公告)号：EP1514930A4
公开(公告)日：2006-11-29
申请号：EP03733385
申请日：2003-06-12
发明人： HINUMA SHUJI , FUJII RYO , HARADA MASATAKA , HOSOYA MASAKI
IPC分类号： A61P9/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07K14/47 , C07K14/705 , C12N15/12 , G01N33/74 , A61K38/17 , A61K45/00 , G01N33/15 , G01N33/50 , G01N33/566
CPC分类号： G01N33/74 , C07K14/4747 , C07K14/705 , G01N2333/726 , G01N2500/02
摘要： By using a G protein-coupled receptor protein containing an amino acid sequence, which is the same or the substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:10, SEQ ID NO:12 or SEQ ID NO:14, or its salt together with humanin , a compound or its salt capable of changing the binding properties of the above receptor protein or its salt to humanin can be efficiently screened.
摘要翻译： 通过使用含有与序列号1，序列号10，序列号12或序列号12所示的氨基酸序列相同或大致相同的氨基酸序列的G蛋白偶联型受体蛋白质 可以有效地筛选能够改变上述受体蛋白质或其盐与人肌肽的结合特性的化合物或其盐，所述化合物或其盐可以有效地筛选。
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公开(公告)号：EP1741792A4
公开(公告)日：2008-11-05
申请号：EP05737007
申请日：2005-04-26
发明人： FUJII RYO , HARADA MASATAKA , HINUMA SHUJI
IPC分类号： C12Q1/68 , A61K31/7088 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/02 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07K14/705 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , G01N33/74
CPC分类号： C07K14/705 , A61K31/7088 , A61K38/00 , G01N33/6896 , G01N33/74 , G01N2333/726 , G01N2500/04
摘要： There is provided, for example, a method of screening an agonist or antagonist characterized by use of a G-protein-conjugated receptor protein containing an amino acid sequence identical with or substantially identical with the amino acid sequence of SEQ ID NO: 1 or its salt and a ligand or its salt so as to effect screening of an agonist or antagonist as for the above receptor protein or salt thereof. This screening method is useful for screening of a preventive/therapeutic agent for nervous system disorder or neuropathic pain.
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公开(公告)号：EP1736775A4
公开(公告)日：2008-03-12
申请号：EP05730037
申请日：2005-04-11
发明人： FUJII RYO , OKUBO SHOICHI , NISHI KAZUNORI , HINUMA SHUJI , MORI MASAAKI
IPC分类号： G01N33/50 , A61K38/17 , A61K45/00 , A61K48/00 , A61P1/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/04 , A61P19/02 , A61P21/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07K14/705 , C12N15/00 , C12Q1/02 , G01N33/15 , G01N33/76
CPC分类号： G01N33/76 , A61K31/403 , A61K31/4155 , A61K31/4523 , A61K38/1796 , C07K14/705 , G01N2333/726
摘要： There is provided, for example, a method of screening an agonist or antagonist of G protein coupled receptor protein or its salt, characterized in that use is made of, containing an amino acid sequence identical to or substantially identical to the amino acid sequence of SEQ ID NO: 1, G protein coupled receptor protein or its salt, and ligand thereof or its salt. This method is useful in the screening of preventive/therapeutic agent for, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disease, tonsil disease, collagenosis, inflammatory disease, leukocytosis, cardiac failure, hereditary muscle disease, muscular dystrophy, myodegeneration disease, myocardial infarction, obesity, diabetes mellitus, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytocytosis, cancer, lung edema, multiple organ failure, etc.
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公开(公告)号：EP1454982A4
公开(公告)日：2005-12-28
申请号：EP02786101
申请日：2002-12-13
发明人： HINUMA SHUJI , KOBAYASHI MAKOTO , ARAI TOSHIMITSU , FUKUSUMI SHOJI , FUJII RYO , KOMATSU HIDETOSHI , MATSUMURA FUMIKA , KAWAMATA YUJI , OGI KAZUHIRO
IPC分类号： A61K38/17 , A61P35/00 , C07K14/47 , C07K14/705 , C12Q1/68 , G01N33/566 , G01N33/68 , C12N15/00 , A61P43/00 , C07K16/18 , C12P21/02 , G01N33/15 , G01N33/50
CPC分类号： A61K38/1709 , C07K14/4726 , C07K14/705 , C12Q1/6886 , C12Q2600/136 , G01N33/566 , G01N33/689 , G01N2333/705 , G01N2333/726
摘要： It is intended to provide a method of analyzing gene expression, a novel use of a receptor protein, etc. More specifically speaking, a method of analyzing gene expression characterized by comprising qualitatively analyzing the individual expression doses of a plural number of genes and thus identifying a gene showing characteristic promotion or inhibition in its expression in specific cells or tissue; a quantification kit to be used in this method; and so on. Moreover, a method of screening a compound or its salt capable of changing the binding properties of a receptor protein, which is a novel G protein-coupled receptor protein having an amino acid sequence being identical or substantially identical with the amino acid sequence represented by SEQ ID NO:9, or its salt to ligands characterized by using the above protein or its salt and a protein (for example, a lectin) showing an affinity for a sugar chain which is one of the ligands is provided.
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公开(公告)号：EP1403281A4
公开(公告)日：2005-06-15
申请号：EP02736088
申请日：2002-06-13
发明人： HINUMA SHUJI , FUJII RYO , FUKUSUMI SHOJI , MORI MASAAKI , YOSHIDA HIROMI
IPC分类号： C07K14/47 , C07K14/705 , C07K14/72 , C12N1/19 , C12N1/21 , C12N15/12 , G01N33/566 , G01N33/92 , A61K38/17 , A61K39/395 , C07K16/18 , C07K16/28 , C12N5/10 , C12P21/02 , C12Q1/68 , G01N33/53 , G01N33/577
CPC分类号： G01N33/566 , C07K14/47 , C07K14/705 , C07K14/723 , G01N33/92
摘要： A GPR7 ligand having the amino acid sequence represented by SEQ ID NO:1, which is optionally brominated at the N−terminal amino acid residue, or a substantially the same amino acid sequence is useful in developing a receptor−binding assay system with the use of the GPR7 expression system, screening a candidate compound for a drug such as an antiobestic, etc.
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