公开(公告)号：EP1617216A4

公开(公告)日：2007-03-21

申请号：EP04728959

申请日：2004-04-22

申请人： TAKEDA PHARMACEUTICAL

发明人： KOBAYASHI MAKOTO ,  HABATA YUGO ,  FUJII RYO ,  HINUMA SHUJI

IPC分类号： G01N33/50 ,  A61K38/17 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P19/02 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P27/00 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  C07K14/72 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/74

CPC分类号： G01N33/74 ,  A61K38/177 ,  G01N2333/726 ,  G01N2500/04

摘要： The use of a G-protein conjugated receptor protein containing an amino acid sequence identical with or substantially identical with the amino acid sequence of SEQ ID No. 1 or a salt thereof and a ligand peptide containing an amino acid sequence represented by any of SEQ ID Nos. 3 to 7 or a salt thereof enables efficient screening of an agonist or antagonist for the above receptor protein or salt thereof.

摘要翻译： 含有与SEQ ID No.1的氨基酸序列相同或基本上相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和含有SEQ ID No.1中任一氨基酸序列的配体肽的用途， No.3-7或其盐能够有效筛选上述受体蛋白质或其盐的激动剂或拮抗剂。

公开(公告)号：EP1454982A4

公开(公告)日：2005-12-28

申请号：EP02786101

申请日：2002-12-13

申请人： TAKEDA PHARMACEUTICAL

发明人： HINUMA SHUJI ,  KOBAYASHI MAKOTO ,  ARAI TOSHIMITSU ,  FUKUSUMI SHOJI ,  FUJII RYO ,  KOMATSU HIDETOSHI ,  MATSUMURA FUMIKA ,  KAWAMATA YUJI ,  OGI KAZUHIRO

IPC分类号： A61K38/17 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/68 ,  C12N15/00 ,  A61P43/00 ,  C07K16/18 ,  C12P21/02 ,  G01N33/15 ,  G01N33/50

CPC分类号： A61K38/1709 ,  C07K14/4726 ,  C07K14/705 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/566 ,  G01N33/689 ,  G01N2333/705 ,  G01N2333/726

摘要： It is intended to provide a method of analyzing gene expression, a novel use of a receptor protein, etc. More specifically speaking, a method of analyzing gene expression characterized by comprising qualitatively analyzing the individual expression doses of a plural number of genes and thus identifying a gene showing characteristic promotion or inhibition in its expression in specific cells or tissue; a quantification kit to be used in this method; and so on. Moreover, a method of screening a compound or its salt capable of changing the binding properties of a receptor protein, which is a novel G protein-coupled receptor protein having an amino acid sequence being identical or substantially identical with the amino acid sequence represented by SEQ ID NO:9, or its salt to ligands characterized by using the above protein or its salt and a protein (for example, a lectin) showing an affinity for a sugar chain which is one of the ligands is provided.

公开(公告)号：EP1619499A4

公开(公告)日：2008-03-05

申请号：EP04729276

申请日：2004-04-23

申请人： TAKEDA PHARMACEUTICAL

发明人： ITO YASUAKI ,  FUJII RYO ,  KOBAYASHI MAKOTO ,  HINUMA SHUJI ,  HASHIMOTO TADATOSHI ,  TANAKA YASUHIRO

IPC分类号： G01N33/50 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/68

CPC分类号： G01N33/5008 ,  G01N33/5011 ,  G01N33/5041 ,  G01N33/68 ,  G01N2333/726 ,  G01N2500/00

摘要： By using a G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same as the amino aid sequence represented by SEQ ID NO:1 or its salt and an ion chemically available metal element or its salt, an agonist or an antagonist to the above receptor protein or its salt can be efficiently screened.

公开(公告)号：EP1457556A4

公开(公告)日：2005-01-19

申请号：EP02790932

申请日：2002-12-27

申请人： TAKEDA PHARMACEUTICAL

发明人： KOBAYASHI MAKOTO ,  ARAI TOSHIMITSU ,  MATSUMURA FUMIKA

IPC分类号： A61P43/00 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/09 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  G01N33/566

CPC分类号： G01N33/5308 ,  C12Q1/6813 ,  C12Q1/6851 ,  C12Q2545/101 ,  C12Q2561/101

摘要： It is intended to provide a method of quantifying a nucleic acid and a kit for quantifying a nucleic acid. More specifically, it is intended to provide a standard comprising a synthetic polynucleotide obtained by chemical synthesis which is to be used for forming a calibration curve employed for quantifying a specific target nucleic acid in a sample, a quantification method and a quantification kit using the same, a method of diagnosing a specific disease, etc. The standard is a synthetic polynucleotide obtained by chemical synthesis. Compared with the existing standards comprising biosynthesized polynucleotides, it has an advantage that a target sequence can be precisely obtained by a convenient method. Moreover, the above-described standard suffers from little biological contamination. Therefore, it is highly safe to the environment and factors disturbing highly precise quantification can be lessened therein.

公开(公告)号：EP1688138A4

公开(公告)日：2008-01-16

申请号：EP04799921

申请日：2004-11-26

申请人： TAKEDA PHARMACEUTICAL

发明人： FUKATSU KOHJI ,  FUJII RYO ,  KOBAYASHI MAKOTO ,  YONEMORI JINICHI ,  TANAKA TOSHIO

IPC分类号： A61K31/192 ,  A61K31/216 ,  A61K31/341 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P43/00 ,  C07C45/68 ,  C07C45/71 ,  C07C59/68 ,  C07C69/734 ,  C07D213/64 ,  C07D213/643 ,  C07D277/34 ,  C07D295/08 ,  C07D295/092 ,  C07D295/096 ,  C07D307/12 ,  C07D307/16 ,  C07D317/54 ,  C07D333/32 ,  C07F7/18 ,  G01N33/15 ,  G01N33/50

CPC分类号： C07D213/643 ,  A61K31/192 ,  A61K31/216 ,  A61K31/341 ,  A61K31/4453 ,  A61K31/5375 ,  C07C45/68 ,  C07C45/71 ,  C07C59/68 ,  C07C69/734 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D213/64 ,  C07D277/34 ,  C07D295/088 ,  C07D295/096 ,  C07D307/12 ,  C07D317/54 ,  C07D333/32 ,  C07F7/1852 ,  C07C49/697 ,  C07C49/67 ,  C07C49/84 ,  C07C49/755 ,  C07C47/575

摘要： A 14273 receptor function regulating agent useful as a preventive/therapeutic agent for diabetes, hyperlipemia, etc. There is provided a 14273 receptor function regulating agent comprising a compound having a group capable of releasing an aromatic ring and a cation.

公开(公告)号：EP1479768A4

公开(公告)日：2006-02-01

申请号：EP03705107

申请日：2003-02-13

申请人： TAKEDA PHARMACEUTICAL

发明人： HINUMA SHUJI ,  HOSOYA MASAKI ,  ITO YASUAKI ,  KOBAYASHI MAKOTO ,  TANAKA HIDEYUKI ,  OKUBO SHOICHI ,  FUJII RYO ,  KIZAWA HIDEKI ,  KAWAMATA YUJI ,  OGI KAZUHIRO ,  HARADA MASATAKA ,  FUKUSUMI SHOJI

IPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P25/00 ,  A61P35/00 ,  C07K16/28

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/28 ,  C07K2319/60 ,  G01N2333/726 ,  G01N2500/00

摘要： By using (1) a G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1 or its salt and (2) a fatty aid or an eicosanoid, it is possible to efficiently screen a compound, which is capable of changing the binding properties of the above receptor protein or its salt to the fatty acid or the eicosanoid, or its salt.