公开(公告)号：EP2776402B1

公开(公告)日：2017-07-26

申请号：EP12781538.9

申请日：2012-10-16

申请人： The Johns Hopkins University

发明人： GUTHRIE, Daryl A. ,  TOSCANO, John, P.

IPC分类号： C07D231/22 ,  C07D231/46 ,  C07D239/62 ,  C07D319/06 ,  A61K31/4155 ,  A61K31/515 ,  A61K31/357 ,  A61K31/366 ,  A61P9/00 ,  A61P35/00

CPC分类号： C07D319/06 ,  C07D231/08 ,  C07D231/22 ,  C07D231/46 ,  C07D239/62

摘要： The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

摘要翻译： 所公开的主题提供了某些N-取代的羟胺衍生物化合物，包含此类化合物的药物组合物和试剂盒以及使用此类化合物或药物组合物的方法。 特别地，所公开的主题提供了一种使用这样的化合物或用于治疗，预防，或延缓疾病或病症的发作和/或发展的药物组合物的方法。 在一些实施方案中，所述疾病或病症选自心血管疾病，局部缺血，再灌注损伤，癌性疾病，肺动脉高压和响应于硝酰基疗法条件来选择。

公开(公告)号：EP2190814A1

公开(公告)日：2010-06-02

申请号：EP08834117.7

申请日：2008-09-26

申请人： The Johns Hopkins University ,  Cardioxyl Pharmaceuticals, INC.

发明人： TOSCANO, John, P. ,  BROOKFIELD, Frederick, Arthur ,  COHEN, Andrew, D. ,  COURTNEY, Stephen, Martin ,  FROST, Lisa, Marie ,  KALISH, Vincent, Jacob

IPC分类号： C07C311/48 ,  C07D333/34 ,  C07D295/192 ,  A61K31/18 ,  A61K31/192 ,  A61K31/235 ,  A61K31/5377 ,  A61P9/04 ,  A61P9/10 ,  C07D333/38

CPC分类号： C07C317/48 ,  C07C311/48 ,  C07D295/155 ,  C07D295/16 ,  C07D295/192 ,  C07D295/26 ,  C07D333/26 ,  C07D333/36 ,  C07D333/38

摘要： The invention relates to N-hydroxylsulfonamide derivatives for formula (I), (II) or (III), in which the variables are as defined in the claims, that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. N-hydroxylsulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of the functional groups on the N-hydroxylsulfonamide derivatives.

公开(公告)号：EP3693363A1

公开(公告)日：2020-08-12

申请号：EP20166739.1

申请日：2007-03-16

申请人： The Johns Hopkins University ,  Cardioxyl Pharmaceuticals, Inc.

发明人： TOSCANO, John, P. ,  COHEN, Andrew, D. ,  COURTNEY, Stephen, Martin ,  FROST, Lisa, Marie ,  KALISH, Vincent, Jacob ,  BROOKFIELD, Frederick, Arthur

IPC分类号： C07D307/64 ,  A61K31/341 ,  A61P9/04

摘要： The invention relates to N -hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N- hydroxysulfonamide derivatives.

公开(公告)号：EP2190814B1

公开(公告)日：2017-02-01

申请号：EP08834117.7

申请日：2008-09-26

申请人： The Johns Hopkins University ,  Cardioxyl Pharmaceuticals, Inc.

发明人： TOSCANO, John, P. ,  BROOKFIELD, Frederick, Arthur ,  COHEN, Andrew, D. ,  COURTNEY, Stephen, Martin ,  FROST, Lisa, Marie ,  KALISH, Vincent, Jacob

IPC分类号： C07C311/48 ,  C07D295/155 ,  C07D295/192 ,  C07D295/16 ,  C07D295/26 ,  C07D333/36 ,  C07D333/38 ,  A61K31/18 ,  A61K31/192 ,  A61K31/235 ,  A61K31/5377 ,  A61P9/04 ,  A61P9/10

CPC分类号： C07C317/48 ,  C07C311/48 ,  C07D295/155 ,  C07D295/16 ,  C07D295/192 ,  C07D295/26 ,  C07D333/26 ,  C07D333/36 ,  C07D333/38

公开(公告)号：EP3490975A1

公开(公告)日：2019-06-05

申请号：EP17754873.2

申请日：2017-07-27

申请人： The Johns Hopkins University

发明人： TOSCANO, John, P. ,  NOURIAN, Saghar ,  GUTHRIE, Daryl, A.

IPC分类号： C07D231/28 ,  C07D239/62 ,  C07D311/56 ,  A61K31/4152 ,  A61P9/10

公开(公告)号：EP3313831A1

公开(公告)日：2018-05-02

申请号：EP16738303.3

申请日：2016-06-25

申请人： The Johns Hopkins University

发明人： TOSCANO, John, P. ,  NOURIAN, Saghar

IPC分类号： C07D311/42 ,  C07D231/50 ,  C07D239/62 ,  A61K31/515 ,  A61K31/4152 ,  A61P9/00

CPC分类号： A61K31/515 ,  A61K31/352 ,  A61K31/4152 ,  A61P9/00 ,  C07D231/50 ,  C07D239/62 ,  C07D311/42

摘要： N-substituted hydroxamic acids with carbon-based leaving groups as efficient HNO donors are disclosed. Pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions also are disclosed.

公开(公告)号：EP2776402A1

公开(公告)日：2014-09-17

申请号：EP12781538.9

申请日：2012-10-16

申请人： The Johns Hopkins University

发明人： GUTHRIE, Daryl A. ,  TOSCANO, John, P.

IPC分类号： C07D231/22 ,  C07D231/46 ,  C07D239/62 ,  C07D319/06 ,  A61K31/4155 ,  A61K31/515 ,  A61K31/357 ,  A61K31/366 ,  A61P9/00 ,  A61P35/00

CPC分类号： C07D319/06 ,  C07D231/08 ,  C07D231/22 ,  C07D231/46 ,  C07D239/62

摘要： The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

摘要翻译： 所公开的主题提供某些N-取代的羟胺衍生物化合物，药物组合物和包含这些化合物的试剂盒，以及使用这些化合物或药物组合物的方法。 特别地，所公开的主题提供了使用这些化合物或药物组合物治疗，预防或延迟疾病或病症发作和/或发展的方法。 在一些实施方案中，疾病或病症选自心血管疾病，局部缺血，再灌注损伤，癌性疾病，肺动脉高压和对硝酰基治疗有反应的病症。