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1.发明公开USE OF ANTI-gp39 ANTIBODIES FOR TREATMENT AND/OR REVERSAL OF LUPUS AND ASSOCIATED KIDNEY DISEASE 审中-公开使用抗gp39抗体治疗和/或退化性狼疮，并与常设肾脏疾病的连接
公开(公告)号：EP1067954A1
公开(公告)日：2001-01-17
申请号：EP99915237.4
申请日：1999-04-02
IPC分类号： A61K38/17 , A61K39/395 , C07K14/52 , C07K14/525 , C07K16/18 , C07K16/28
CPC分类号： C07K16/2875 , A61K38/00
摘要： A method of treating lupus using anti-gp39 antibodies or fragments is provided. Such treatment has been shown to reverse disease, and in particular lupus-associated kidney disease, the major killer of lupus subjects.
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公开(公告)号：EP3094346A2
公开(公告)日：2016-11-23
申请号：EP15737353.1
申请日：2015-01-23
发明人： NOELLE, Randolph, J. , CEERAZ, Sabrina , LEMERCIER, Isabelle , NOWAK, Elizabeth , LINES, Janet , WANG, Li , SPALLER, Mark
IPC分类号： A61K39/00 , A61K39/395 , A61K38/00 , A61K38/10
摘要： The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.
摘要翻译： 本发明涉及抑制VISTA活性的肽，多聚体，缀合物，类似物，衍生物或模拟物。 本发明进一步考虑了VISTA拮抗剂肽，多聚体，缀合物，衍生物或其模拟物的治疗用途，包括治疗或预防癌症，细菌感染，病毒感染，寄生虫感染和真菌感染以及拮抗剂的研究用途。
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公开(公告)号：EP2892558B1
公开(公告)日：2019-04-10
申请号：EP13834707.5
申请日：2013-09-09
发明人： NOELLE, Randolph, J.
IPC分类号： A61K39/395 , A61K48/00 , A61P35/00
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公开(公告)号：EP3094346B1
公开(公告)日：2019-12-11
申请号：EP15737353.1
申请日：2015-01-23
发明人： NOELLE, Randolph, J. , CEERAZ, Sabrina , LEMERCIER, Isabelle , NOWAK, Elizabeth , LINES, Janet , WANG, Li , SPALLER, Mark
IPC分类号： A61K39/00 , A61K39/395 , A61K38/00 , A61K38/10 , G01N33/566 , C07K16/28 , C07K7/08
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公开(公告)号：EP2864352B1
公开(公告)日：2018-08-08
申请号：EP13806673.3
申请日：2013-06-21
发明人： NOELLE, Randolph, J. , CEERAZ, Sabrina , LEMERCIER, Isabelle , NOWAK, Elizabeth , LINES, Janet, Louise
IPC分类号： C07K14/47 , C07K16/28 , C07K19/00 , A61K39/00 , A61P35/00 , A61P37/00 , A01K67/027 , A61K38/17 , C07K14/705 , C12N15/113
CPC分类号： C07K16/18 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0325 , A01K2267/0368 , A01K2267/0387 , A61K38/00 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/70503 , C07K14/70532 , C07K16/2827 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/735 , C12N15/1138 , C12N2310/14 , A61K31/00
摘要： The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease and type 1 or type 2 diabetes.
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公开(公告)号：EP0831906A1
公开(公告)日：1998-04-01
申请号：EP96921309.0
申请日：1996-06-06
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505
摘要： Method for the treatment of multiple sclerosis and other T cell mediated autoimmune disorders is described. The method involves administering to a subject a therapeutically effective amount of an antagonist of a receptor on a surface of a T cell which mediates contact dependent helper effector functions, for example, an anti-gp39 antibody.
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公开(公告)号：EP4240409A1
公开(公告)日：2023-09-13
申请号：EP21890045.4
申请日：2021-11-04
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公开(公告)号：EP3442579A2
公开(公告)日：2019-02-20
申请号：EP17783330.8
申请日：2017-04-14
发明人： MOLLOY, Michael , ROTHSTEIN, Jay , CARRIERE, Catherine , NOELLE, Randolph, J. , DELONG, Sabrina , LEMERCIER, Isabelle
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28 , C07K16/30
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