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1.发明授权SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY 有权国土DEFINED大环化合物WHICH药品DISCOVERY是合适
公开(公告)号：EP1648922B1
公开(公告)日：2010-12-01
申请号：EP04761605.7
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： DESLONGCHAMPS, Pierre , DORY, Yves , PETERSON, Mark , BENAKLI, Kamel , MARSAULT, Eric , OUELLET, Luc , RAMASESHAN, Mahesh , VEZINA, Martin , FORTIN, Daniel , LAN, Ruoxi , LI, Shigui , VILLENEUVE, Gérald , HOVEYDA, Hamid , BEAUBIEN, Sylvie , FRASER, Graeme
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
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2.发明授权SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY 有权国土DEFINED大环化合物WHICH药品DISCOVERY是合适
公开(公告)号：EP1648922B9
公开(公告)日：2013-04-03
申请号：EP04761605.7
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： DESLONGCHAMPS, Pierre , DORY, Yves , PETERSON, Mark , BENAKLI, Kamel , MARSAULT, Eric , OUELLET, Luc , RAMASESHAN, Mahesh , VEZINA, Martin , FORTIN, Daniel , LAN, Ruoxi , LI, Shigui , VILLENEUVE, Gérald , HOVEYDA, Hamid , BEAUBIEN, Sylvie , FRASER, Graeme
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
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公开(公告)号：EP1633774B1
公开(公告)日：2010-02-17
申请号：EP04737852.6
申请日：2004-06-18
申请人： Tranzyme Pharma Inc.
发明人： FRASER, Graeme , MARSAULT, Eric , PETERSON, Mark , HOVEYDA, Hamid , BEAUBIEN, Sylvie , BENAKLI, Kamel , DEZIEL, Robert
CPC分类号： C07C213/08 , A61K38/12 , A61K38/2214 , C07C41/18 , C07C67/343 , C07D273/00 , C07D413/06 , C07D498/04 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.
摘要翻译： 本发明涉及式（I）的新型大环化合物及其药学上可接受的盐，水合物或溶剂化物：其中R 1，R 2，R 3，R 4，R 5，R 6，n1，m，p Z1，Z2和Z3如 在说明书中描述。 本发明还涉及式（I）化合物，其是胃动素受体的拮抗剂并且可用于治疗与该受体相关的病症并伴有或伴随有运动功能障碍。
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公开(公告)号：EP1648923A1
公开(公告)日：2006-04-26
申请号：EP04761607.3
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： DESLONGCHAMPS, Pierre , DORY, Yves , OUELLET, Luc , VILLENEUVE, Gérald , RAMASESHAN, Mahesh , FORTIN, Daniel , PETERSON, Mark , HOVEYDA, Hamid , BEAUBIEN, Sylvie , MARSAULT, Eric
CPC分类号： C07K1/047 , C07K5/0802
摘要： Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译： 公开了结合肽键替代物的新型空间定义的大环化合物。 然后使用这些大环化合物的文库来选择与特定生物学目标呈现特异性相互作用的一种或多种大环化合物物种。 具体而言，公开了本发明的化合物作为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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公开(公告)号：EP1633774A1
公开(公告)日：2006-03-15
申请号：EP04737852.6
申请日：2004-06-18
申请人： Tranzyme Pharma Inc.
发明人： FRASER, Graeme , MARSAULT, Eric , PETERSON, Mark , HOVEYDA, Hamid , BEAUBIEN, Sylvie , BENAKLI, Kamel , DEZIEL, Robert
CPC分类号： C07C213/08 , A61K38/12 , A61K38/2214 , C07C41/18 , C07C67/343 , C07D273/00 , C07D413/06 , C07D498/04 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.
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6.发明授权SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY 有权国土DEFINED大环化合物WHICH药品DISCOVERY是合适
公开(公告)号：EP1648922B3
公开(公告)日：2012-08-15
申请号：EP04761605.7
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： DESLONGCHAMPS, Pierre , DORY, Yves , PETERSON, Mark , BENAKLI, Kamel , MARSAULT, Eric , OUELLET, Luc , RAMASESHAN, Mahesh , VEZINA, Martin , FORTIN, Daniel , LAN, Ruoxi , LI, Shigui , VILLENEUVE, Gérald , HOVEYDA, Hamid , BEAUBIEN, Sylvie , FRASER, Graeme
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
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7.发明授权SPATIALLY-DEFINED MACROCYCLES INCORPORATING PEPTIDE BOND SURROGATES 有权国土DEFINED大环肽键SURROGATE CONTAIN
公开(公告)号：EP1648923B1
公开(公告)日：2008-12-31
申请号：EP04761607.3
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： DESLONGCHAMPS, Pierre , DORY, Yves , OUELLET, Luc , VILLENEUVE, Gérald , RAMASESHAN, Mahesh , FORTIN, Daniel , PETERSON, Mark , HOVEYDA, Hamid , BEAUBIEN, Sylvie , MARSAULT, Eric
CPC分类号： C07K1/047 , C07K5/0802
摘要： Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
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公开(公告)号：EP1648922A1
公开(公告)日：2006-04-26
申请号：EP04761605.7
申请日：2004-08-02
申请人： Tranzyme Pharma Inc.
发明人： DESLONGCHAMPS, Pierre , DORY, Yves , PETERSON, Mark , BENAKLI, Kamel , MARSAULT, Eric , OUELLET, Luc , RAMASESHAN, Mahesh , VEZINA, Martin , FORTIN, Daniel , LAN, Ruoxi , LI, Shigui , VILLENEUVE, Gérald , HOVEYDA, Hamid , BEAUBIEN, Sylvie
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译： 公开了含有特定构象控制元件的新型空间限定的大环化合物。 然后使用这些大环化合物的文库来选择与特定生物学目标呈现特异性相互作用的一种或多种大环化合物物种。 具体而言，公开了本发明的化合物作为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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