公开(公告)号：EP3155093A4

公开(公告)日：2018-02-21

申请号：EP15810268

申请日：2015-06-15

申请人： UNIV WEST VIRGINIA

发明人： PANACCIONE DANIEL G ,  ROBINSON SARAH L

IPC分类号： C12N9/02 ,  C12N15/52 ,  C12P17/18

CPC分类号： C12P17/182 ,  C12N15/52

摘要： The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) or any fungus having a pathway similar to Aspergillus fumigatus and expressing one or more genes of the ergot alkaloid biosynthesis pathway from one or more fungus selected from the group consisting of Epichloë festucae var. lolii×Epichloë typhina isolate Lp1 (E. sp. Lp1); Claviceps species; Claviceps africana (C. africana); Claviceps gigantea (C. gigantea); Epichloë coenophiala and Periglandula species, wherein gene easA or gene easM is inactivated in said A. fumigatus or said fungus having a pathway similar to Aspergillus fumigatus, is provided.