摘要:
The invention provides a microfluidic system and method to rapidly analyze large number of compounds or complex mixtures of compounds, particularly, low abundance cellular proteins involved in cell signaling pathways. In one aspect, an integrated microfluidic system (1) comprises an upstream separation module (2) (preferably, a multi-dimensional separation device (2a)), a microfluidic device (5) for on-device protein digestion of substantially separated proteins received from the upstream separation module (2), a downstream separation module (14) for separating digestion products of said proteins, a peptide analysis module (17) and a processor (18) for determining the amino acid sequence of said proteins. Preferably, the integrated microfluidic system (1) comprises an interfacing microfluidic device (5i) between the downstream separation module (14) and the peptide analysis module (17).
摘要:
A method of making anisotropic carbon foam material includes deashing and hydrogenating bituminous coal, separating asphaltenes from oils contained in the coke precursor, coking the material to create a carbon foam. In one embodiment of the invention, the carbon foam is subsequently graphitized. The pores within the foam material are preferably generally of equal size. The pore size and carbon foam material density may be controlled by (a) altering the percentage volatiles contained within the asphaltenes to be coked, (b) mixing the asphaltenes with different coking precursors which are isotropic in nature, or (c) modifying the pressure under which coking is effected. In another embodiment of the invention, solvent separation is employed on raw bituminous coal and an isotropic carbon foam is provided. The carbon foam materials of the present invention are characterized by having high compressive strength as compared with prior known carbon foam materials. A further embodiment is disclosed wherein the pitch material which is employed as a feedstock in the process may be coal feedstock or a petroleum feedstock employed alone or in combination with each other. In another embodiment, an inert gas is saturated into the asphaltenes under a first pressure and coking is subsequently effected at a second pressure lower than the first to facilitate coking.
摘要:
A method of making an anisotropic or isotropic carbon foam include introducing at least one reinforcing additive which may be carbon nanofibers, carbon nanotubes, chopped graphite fibers, crushed green coke, crushed calcined coke or combinations thereof during the process of manufacturing the carbon foam to enhance selected strength properties of the resultant foam. A resultant product is also disclosed.
摘要:
Venous compression in the neck reduced the extent of axonal injury in a standardized mild TBI model in rodents. The mechanism restricted brain venous drainage and increased the central nervous system blood volume and pressure, thus shifting intracranial physiology to the steep part of the volume-compliance curve. The lack of compliance inside the confines of the skull and spinal canal prevented slosh energy absorption and the resultant axonal injury by causing them to approach a more elastic collision when the skull was struck during the weight drop method. A first embodiment can be a device comprising a means to reduce SLOSH energy absorption in a fluid containing organism by reducing the flow of one or more outflow vessels of the cranium by compressing said vessels.
摘要:
A method of making anisotropic carbon foam material includes deashing and hydrogenating bituminous coal, separating asphaltenes from oils contained in the coke precursor, coking the material to create a carbon foam. In one embodiment of the invention, the carbon foam is subsequently graphitized. The pores within the foam material are preferably generally of equal size. The pore size and carbon foam material density may be controlled by (a) altering the percentage volatiles contained within the asphaltenes to be coked, (b) mixing the asphaltenes with different coking precursors which are isotropic in nature, or (c) modifying the pressure under which coking is effected. In another embodiment of the invention, solvent separation is employed on raw bituminous coal and an isotropic carbon foam is provided. A related carbon foam product is disclosed. The carbon foam materials of the present invention are characterized by having high compressive strength as compared with prior known carbon foam materials. A further embodiment is disclosed wherein a petroleum pitch is employed as the feedstock either alone or in combination with a coal feedstock.
摘要:
A contrawound helical antenna (100, 130) produces a uniformly directed circulation of magnetic current (M) with a plurality of magnetic dipole elements (32, 34, 35). In one embodiment, the magnetic dipole elements (32, 34) have the same curvature, and the magnetic currents (M) on respective magnetic dipole elements (32, 34) are each directed in the same direction, relative to the central signal coupler (18) of the magnetic dipole antenna (100). In another embodiment, the magnetic dipole elements (32, 35) have the opposite curvature, and the magnetic currents (M) on respective magnetic dipole elements (32, 35) are each directed in opposite directions, relative to the central signal coupler (18) of the magnetic dipole antenna (130).
摘要:
The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) or any fungus having a pathway similar to Aspergillus fumigatus and expressing one or more genes of the ergot alkaloid biosynthesis pathway from one or more fungus selected from the group consisting of Epichloë festucae var. lolii×Epichloë typhina isolate Lp1 (E. sp. Lp1); Claviceps species; Claviceps africana (C. africana); Claviceps gigantea (C. gigantea); Epichloë coenophiala and Periglandula species, wherein gene easA or gene easM is inactivated in said A. fumigatus or said fungus having a pathway similar to Aspergillus fumigatus, is provided.
摘要:
A method of monitoring a subject for medical conditions includes causing light to impinge on at least one eye of the subject, directing reflected light from such light beam to photosensors, converting the received reflected light to corresponding electrical signals (202) which are delivered to a processor. Processing the signals by effecting a comparison between stored information (210) regarding the medical condition and the data provided by the monitoring (202) to determine if an undesired medical condition exists and, if so, communicating such result (214). The cycle is repeated at predetermined intervals which may be short or prolonged. The stored information may be information relating to the specific subject or general information regarding normal and abnormal conditions of the eye representative of toxicity. The eyes may be monitored sequentially or simultaneously. Related apparatus is provided.