公开(公告)号：EP1796704A2

公开(公告)日：2007-06-20

申请号：EP05808582.0

申请日：2005-09-01

申请人： Unigen, Inc.

发明人： JO, Tae-Hyung, Woosung Apt. 302-201 ,  WOO, Sung-Sick ,  CHA, Ji-Min ,  KIM, Dong-Seon ,  LEE, Young-Chul ,  DO, Seon-Gil Hanul 2nd Apt. 201-1106, 724 ,  KIM, Jong-Han ,  KIM, Tae-Woo ,  SUNG, Hee-Sun

IPC分类号： A61K36/74 ,  A61K36/82 ,  A61K36/539

CPC分类号： A61K36/74 ,  A61K36/539 ,  A61K36/82 ,  A61K2300/00

摘要： The present invention relates to a composition for the prevention or treatment of physiological and pathological disorders mediated by cyclooxygenase (COX) and/or 5 -lipoxygenase (5-LO) comprising Uncaria genus plant, in particular, Uncaria gambir, or its extract, and to a combined composition of said Uncaria genus plant extract and Scutellaria baicalensis extract and/or Camellia sinensis extract. The present composition shows excellent COX and/5-LO inhibition effects, and thus can be used for the prevention or treatment of disease and disorders mediated by various COX pathway and/or 5-LO pathway, including osteoarthritis and rheumatoid arthritis.

公开(公告)号：EP1863498A2

公开(公告)日：2007-12-12

申请号：EP06716434.3

申请日：2006-03-17

申请人： Unigen, Inc.

发明人： WOO, Sung-Sick ,  KIM, Dong-Seon ,  DO, Seon-Gil ,  LEE, Young-Chul ,  OH, Mi-Sun ,  CHA, Ji-Min ,  JO, Tae-Hyung

IPC分类号： A61K31/7032 ,  A61K31/352 ,  A61K36/899 ,  A61P37/08

CPC分类号： A61K36/899 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7032 ,  A61K36/886

摘要： The present invention relates to a pharmaceutical composition for the prevention or treatment of diseases mediated by excessive histamine comprising naturally-derived isoorientin, a use of isoorientin for the manufacture of a medicament for the prevention or treatment of diseases mediated by excessive histamine, and a method for preventing or treating diseases mediated by excessive histamine comprising administering a therapeutically effective amount of isoorientin to a subject. The composition, use and method of the present invention show excellent histamine suppression effects, and so can be used for the prevention or treatment of various kinds of allergic disease, atopic disease, inflammatory disease, skin disease, hyperacidity and nervous system disorder.