公开(公告)号：EP3010928A1

公开(公告)日：2016-04-27

申请号：EP14813460.4

申请日：2014-06-16

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： BROWNELL, Lidia, Alfaro ,  CHU, Min ,  HONG, Mei-Feng ,  HYUN, Eu-Jin ,  JIA, Qi ,  JIAO, Ping ,  KIM, Hyun-Jin ,  KIM, Mi-Ran ,  KIM, Tae-Woo ,  LEE, Bo-Su ,  LEE, Young-Chul ,  MOORE, Breanna ,  NAM, Jeong-Bum ,  OH, Mi-Sun ,  PARK, Mi-Hye ,  YIMAM, Mesfin ,  ZHANG, Qian

IPC分类号： C07H15/20 ,  C07K14/415 ,  A61K36/605 ,  A61K36/48 ,  A61P19/02

CPC分类号： A61K36/605 ,  A61K31/05 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7008 ,  A61K31/7028 ,  A61K31/7034 ,  A61K36/48 ,  A61K36/534 ,  A61K2300/00

摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

公开(公告)号：EP1796704A2

公开(公告)日：2007-06-20

申请号：EP05808582.0

申请日：2005-09-01

申请人： Unigen, Inc.

发明人： JO, Tae-Hyung, Woosung Apt. 302-201 ,  WOO, Sung-Sick ,  CHA, Ji-Min ,  KIM, Dong-Seon ,  LEE, Young-Chul ,  DO, Seon-Gil Hanul 2nd Apt. 201-1106, 724 ,  KIM, Jong-Han ,  KIM, Tae-Woo ,  SUNG, Hee-Sun

IPC分类号： A61K36/74 ,  A61K36/82 ,  A61K36/539

CPC分类号： A61K36/74 ,  A61K36/539 ,  A61K36/82 ,  A61K2300/00

摘要： The present invention relates to a composition for the prevention or treatment of physiological and pathological disorders mediated by cyclooxygenase (COX) and/or 5 -lipoxygenase (5-LO) comprising Uncaria genus plant, in particular, Uncaria gambir, or its extract, and to a combined composition of said Uncaria genus plant extract and Scutellaria baicalensis extract and/or Camellia sinensis extract. The present composition shows excellent COX and/5-LO inhibition effects, and thus can be used for the prevention or treatment of disease and disorders mediated by various COX pathway and/or 5-LO pathway, including osteoarthritis and rheumatoid arthritis.