公开(公告)号：EP2264430A3

公开(公告)日：2014-05-14

申请号：EP10182264.1

申请日：2000-11-29

申请人： XY, LLC

发明人： Buchanan, Kristopher S. ,  Herickhoff, Lisa

IPC分类号： G01N15/14 ,  G01N15/00 ,  G01N15/10

CPC分类号： G01N15/1404 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1413 ,  G01N2015/1415 ,  G01N2015/149 ,  Y10T436/101666

摘要： A flow cytometer system, comprising a sample injection tube having an injection point through which a sample may be introduced, a sheath fluid container having a bottom end and wherein said sample injection tube is located within said sheath fluid container, a sheath fluid port connected to said sheath fluid container, a first axial motion surface in a nozzle, a second axial motion surface in said nozzle, a limited maximal acceleration differentiation transition area between said first axial motion surface in said nozzle and said second axial motion surface in said nozzle wherein said limited maximal acceleration differentiation transition area is coordinated with said sample so as to be affirmatively limited to not exceed the practical capabilities of said sample over its length and an analytical system which senses below said nozzle.

摘要翻译： 已经发明了一种用于流式细胞仪的改进的喷嘴系统，用于平坦样品的高效取向和分选过程，并且专用诸如马或牛精子细胞的物品。 这种改进的喷嘴系统包括具有新颖的内表面几何形状的喷嘴（16），其可以轻轻地加速细胞并且可以在（c）喷嘴内包括椭圆形的单个扭转内表面元件，即单个扭转定向喷嘴 （6）。 椭圆形的单个扭转内表面元件（例如）（8,9,10）可以具有层流表面并且可以产生最简单的流动路径，用于施加以加速性质或取向的流体动力作用的最小力，即 单一的扭转取向力将诸如动物精子细胞的平坦样品（16）定向到正确的方向，以便在临床应用中进行分析和有效分选过程，用于研究和动物授精行业。

公开(公告)号：EP2180307B1

公开(公告)日：2013-11-20

申请号：EP10001278.0

申请日：2000-11-29

申请人： XY, LLC

发明人： Buchanan, Kristopher S. ,  Herickhoff, Lisa

IPC分类号： G01N15/14 ,  G01N15/10 ,  G01N33/569

CPC分类号： G01N15/1404 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1413 ,  G01N2015/1415 ,  G01N2015/149 ,  Y10T436/101666

摘要： An improved nozzle system for a flow cytometer have been invented for a high efficiency orientation and sorting process of a flat sample and dedicates items such as equine or bovine sperm cells. This improved nozzle system comprises a nozzle (16) with a novel interior surface geometry that can both gently accelerate the cells and can include an elliptical-like, single torsional interior surface element within (c) the nozzle, i.e., a single torsional orientation nozzle (6). The elliptical-like, single torsional interior surface element (e.g.) (8, 9, 10) may have a laminar flow surface and may produce the simplest flow path for applying minimal forces which act in either an accelerative nature or orienting hydrodynamic forces, namely, the single torsional orientation forces, to orient a flat sample (16) such as animal sperm cells into a proper direction for an analyzing and efficiently sorting process in clinical use, for research and for the animal insemination industry.

摘要翻译： 用于流式细胞仪的改进的喷嘴系统已经被发明用于扁平样品的高效定向和分选过程，并且专用诸如马或牛精细胞的物品。 这种改进的喷嘴系统包括具有新颖的内表面几何形状的喷嘴（16），其既可以平缓地加速细胞，又可以在（c）喷嘴内包括椭圆形的单个扭转内表面元件，即单个扭转取向喷嘴 （6）。 类似椭圆形的单个扭转内表面元件（例如）（8,9,10）可以具有层流表面并且可以产生最简单的流动路径，用于施加作用于加速特性或定向流体动力的最小力，即 ，单一的扭转取向力，将诸如动物精子细胞的扁平样品（16）定向成适当的方向，用于临床应用，研究和动物授精行业中的分析和有效分选过程。

公开(公告)号：EP2180307A3

公开(公告)日：2012-10-03

申请号：EP10001278.0

申请日：2000-11-29

申请人： XY, LLC

发明人： Buchanan, Kristopher S. ,  Herickhoff, Lisa

IPC分类号： G01N15/14

CPC分类号： G01N15/1404 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1413 ,  G01N2015/1415 ,  G01N2015/149 ,  Y10T436/101666

摘要： An improved nozzle system for a flow cytometer have been invented for a high efficiency orientation and sorting process of a flat sample and dedicates items such as equine or bovine sperm cells. This improved nozzle system comprises a nozzle (16) with a novel interior surface geometry that can both gently accelerate the cells and can include an elliptical-like, single torsional interior surface element within (c) the nozzle, i.e., a single torsional orientation nozzle (6). The elliptical-like, single torsional interior surface element (e.g.) (8, 9, 10) may have a laminar flow surface and may produce the simplest flow path for applying minimal forces which act in either an accelerative nature or orienting hydrodynamic forces, namely, the single torsional orientation forces, to orient a flat sample (16) such as animal sperm cells into a proper direction for an analyzing and efficiently sorting process in clinical use, for research and for the animal insemination industry.

公开(公告)号：EP2264430A2

公开(公告)日：2010-12-22

申请号：EP10182264.1

申请日：2000-11-29

申请人： XY, LLC

发明人： Buchanan, Kristopher S. ,  Herickhoff, Lisa

IPC分类号： G01N15/14

CPC分类号： G01N15/1404 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1413 ,  G01N2015/1415 ,  G01N2015/149 ,  Y10T436/101666

摘要： A flow cytometer system, comprising a sample injection tube having an injection point through which a sample may be introduced, a sheath fluid container having a bottom end and wherein said sample injection tube is located within said sheath fluid container, a sheath fluid port connected to said sheath fluid container, a first axial motion surface in a nozzle, a second axial motion surface in said nozzle, a limited maximal acceleration differentiation transition area between said first axial motion surface in said nozzle and said second axial motion surface in said nozzle wherein said limited maximal acceleration differentiation transition area is coordinated with said sample so as to be affirmatively limited to not exceed the practical capabilities of said sample over its length and an analytical system which senses below said nozzle.

摘要翻译： 一种流式细胞仪系统，包括具有注入点的样本注入管，样本可以通过该注入点引入;鞘液流体容器，具有底端，并且其中所述样本注入管位于所述鞘液流体容器内;鞘流体端口，连接到 所述鞘液容器，喷嘴中的第一轴向运动表面，所述喷嘴中的第二轴向运动表面，所述喷嘴中的所述第一轴向运动表面和所述喷嘴中的所述第二轴向运动表面之间的有限的最大加速度区分过渡区，其中所述 有限的最大加速度区分过渡区域与所述样本协调，以便被肯定地限制为不超过所述样本在其长度上的实际能力以及在所述喷嘴下面感测的分析系统。

公开(公告)号：EP2264430B1

公开(公告)日：2018-01-10

申请号：EP10182264.1

申请日：2000-11-29

申请人： XY, LLC

发明人： Buchanan, Kristopher S. ,  Herickhoff, Lisa

IPC分类号： G01N15/14 ,  G01N15/00 ,  G01N15/10

CPC分类号： G01N15/1404 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1413 ,  G01N2015/1415 ,  G01N2015/149 ,  Y10T436/101666

摘要： An improved nozzle system for a flow cytometer have been invented for a high efficiency orientation and sorting process of a flat sample and dedicates items such as equine or bovine sperm cells. This improved nozzle system comprises a nozzle (16) with a novel interior surface geometry that can both gently accelerate the cells and can include an elliptical-like, single torsional interior surface element within (c) the nozzle, i.e., a single torsional orientation nozzle (6). The elliptical-like, single torsional interior surface element (e.g.) (8, 9, 10) may have a laminar flow surface and may produce the simplest flow path for applying minimal forces which act in either an accelerative nature or orienting hydrodynamic forces, namely, the single torsional orientation forces, to orient a flat sample (16) such as animal sperm cells into a proper direction for an analyzing and efficiently sorting process in clinical use, for research and for the animal insemination industry.