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1.发明公开
公开(公告)号：EP3417270A1
公开(公告)日：2018-12-26
申请号：EP16714352.8
申请日：2016-03-30
发明人： HAYDEN, Oliver , RICHTER, Lukas , UGELE, Matthias
CPC分类号： G01N15/1404 , B01L3/502776 , B01L2200/0663 , G01N15/147 , G01N15/1484 , G01N2015/1006 , G01N2015/1409 , G01N2015/1411 , G01N2015/1413 , G01N2015/1415 , G01N2015/1497
摘要： A technique is presented for aligning, in a desired region within a flow chamber of a flow cell, a non-spherical biological entity carried in a sample. The flow chamber has a rectangular cross-section. A bottom flow input module, a top flow input module and a sample input module provide a viscoelastic first fluid, a second viscoelastic fluid, and the sample, respectively, to the flow chamber. The first and the second viscoelastic fluids laminarly flow along a bottom and a top wall of the flow chamber and the sample laminarly flows sandwiched between them. By controlling rate of flow of the first and/or the second viscoelastic fluids the sample flow, and thus the non-spherical biological entity, is focused in the desired region. A gradient of sheer within the sample flow set up due to the first and second viscoelastic fluids orients the non-spherical biological entity in the desired region.
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公开(公告)号：EP3410096A1
公开(公告)日：2018-12-05
申请号：EP17744092.2
申请日：2017-01-20
申请人： Sysmex Corporation
IPC分类号： G01N15/00 , G01N33/493 , G01N35/08
CPC分类号： G01N15/1404 , G01N15/00 , G01N33/493 , G01N35/08 , G01N2015/1409 , H04N5/225
摘要： Provided is a biological sample imaging device and a biological sample imaging method that are capable of disposing a sufficient number of large-sized particles in a biological sample so as to be moderately dispersed within an imaging range. The biological sample imaging method includes: a first step of introducing a biological sample (104) containing particles into a liquid flow channel (40); a second step of causing the biological sample (104) introduced into the liquid flow channel (40) to flow in a forward direction; a third step of causing the biological sample (104) to flow in a reverse direction after the second step; and an imaging step of taking, in an imaging cell (14), images of the particles contained in the biological sample (104) that remains in the liquid flow channel (40) after the third step.
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公开(公告)号：EP1592957B1
公开(公告)日：2018-10-10
申请号：EP04711397.2
申请日：2004-02-16
CPC分类号： G01N15/10 , G01N1/2035 , G01N1/38 , G01N35/085 , G01N2001/1012 , G01N2001/383 , G01N2015/025 , G01N2015/1087 , G01N2015/1409 , G01N2015/1493 , G01N2035/1032 , Y10T436/25625
摘要： A multi-stage dilution device, comprising a first stage dilution apparatus (A), and a second stage dilution apparatus (B), each of the stage dilution device comprising:-(i) a housing ( 1 ) having a diluent inlet ( 7 ); (ii) a sample inlet ( 2 ) having a sample introducer within the housing ( 1 ) adapted to introduce the sample at an introducer point ( 4 ) within the housing ( 1 ); and, (iii) a mixing conduit ( 5 ) mounted at least partially within the housing ( 1 ), the mixing conduit ( 5 ) having an inlet section comprising a mouth ( 10 ), and a fluid outlet ( 8 ), and a throat section ( 9 ) capable of producing a pressure drop within the mixing conduit ( 5 ), the pressure drop being sufficient to draw sample through the sample inlet ( 2 ); the introducer point ( 4 ) of the sample inlet ( 2 ) being proximate the mixing conduit inlet; and wherein the fluid output ( 8 ) of the first stage dilution apparatus (A) is in communication with the sample inlet ( 2 ) of the second stage dilution apparatus (B). A method of diluting a sample is also disclosed.
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4.发明公开
公开(公告)号：EP3214524A4
公开(公告)日：2018-07-18
申请号：EP15854482
申请日：2015-09-14
申请人： SONY CORP
发明人： AZUMA HIROKO , KATO YASUNOBU , OTSUKA FUMITAKA
CPC分类号： G01N15/1404 , G01N15/14 , G01N2015/1409 , G05D7/06
摘要： A technology is provided, capable of reducing the time required for the flow velocity of a laminar flow to stabilize, and of providing more finely responsive control. The present technology provides a control apparatus for controlling a flow velocity of a laminar flow, the apparatus including: a pressurization unit configured to pressurize a fluid that is to form the laminar flow; an air pressure measurement unit configured to measure a pressure applied to the fluid by the pressurization unit; a water pressure measurement unit configured to measure a water pressure of the fluidpressurizedby the pressurization unit; and a control unit configured to control pressure force applied to the fluid by the pressurization unit on the basis of either the air pressure measured by the air pressure measurement unit or the water pressure measured by the water pressure measurement unit, wherein the control unit provides switching between control based on the air pressure measured by the air pressure measurement unit and control based on the water pressure measured by the water pressure measurement unit.
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5.发明授权
公开(公告)号：EP1834167B1
公开(公告)日：2018-02-14
申请号：EP05852982.7
申请日：2005-12-02
申请人： XY, LLC
CPC分类号： G01N15/1484 , B01L3/0296 , B01L3/5027 , B01L2200/027 , B01L2200/0684 , B01L2200/141 , B01L2400/0481 , G01N35/1095 , G01N2015/1409 , G01N2015/1481 , G01N2015/149 , Y10T137/0318 , Y10T137/1624 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
摘要： A fluid handling and delivery system useful in generating a fluid stream (7) in the flow path (8) of microfluidic device (16). The system comprises a variable volume container (1) having a flexible wall (2) which acts on an amount of fluid (3) within the variable volume container (1) in response to an amount of pressure (4) exerted on the exterior surface (5) of the flexible wall (2) by an amount of gas (6). The amount of pressure (4) exerted on the exterior surface (5) of flexible wall (2) continuously adjusts the volume of the variable volume container (1) to act on the amount of fluid (3) to generate a fluid stream (7) in the flow path (8).
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公开(公告)号：EP3109616A1
公开(公告)日：2016-12-28
申请号：EP16182851.2
申请日：2006-02-01
IPC分类号： G01N15/14
CPC分类号： G01N21/6428 , C12M47/04 , G01N15/1404 , G01N15/1459 , G01N2015/1409 , G01N2015/1411 , G01N2015/149
摘要： Apparatus for sorting and orienting sperm cells has a pair or walls (314, 316) in confronting relationship forming a flow chamber (312) having an inlet, a downstream outlet, and intermediate detector region (338). The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid (328) containing the cells (330) to be sorted. The first and second streams have respective flow rates relative to the third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells (330) are oriented parallel to the walls (314, 316). A detector (340) detects desired cells (330) and a sorter (356) downstream of the detector (340) sorts the desired cells (330) from the stream.
摘要翻译： 用于分选和定向精子细胞的装置具有面对关系的一对或多个壁（314,316），形成具有入口，下游出口和中间检测器区域（338）的流动室（312）。 入口接收第一和第二间隔开的输入流体流和包含要分选的单元（330）的第三流体样品流体（328）。 第一和第二流具有相对于第三流的相应流速，使得第三流收缩形成相对窄的样品流，使得电池（330）平行于壁（314,316）取向。 检测器（340）检测期望的单元（330）并且检测器（340）下游的分选器（356）从流中对期望的单元（330）进行分类。
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公开(公告)号：EP2864849A4
公开(公告)日：2016-03-09
申请号：EP13806142
申请日：2013-06-20
申请人： BIO RAD LABORATORIES
CPC分类号： G01N15/14 , B01F3/088 , B01F13/0059 , B01F15/0441 , G01N15/1404 , G01N2015/1006 , G01N2015/1409 , G05D11/131
摘要： Disclosed is a system that can mix deionized water and concentrated sheath fluid to provide sheath fluid in a flow cytometer system having a desired concentration. Flow rates are low, which substantially match the flow rate of sheath fluid through the nozzle, so that turbulence and air bubbles are not formed in the sheath fluid. The available deionized water is then used for back flushing and removal of sample cells and deposited salts from the sheath fluid.
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8.发明公开
公开(公告)号：EP2743673A4
公开(公告)日：2015-03-18
申请号：EP13823849
申请日：2013-06-10
申请人： SONY CORP
发明人： MURAKI YOSUKE
CPC分类号： B01L3/502 , G01N15/1404 , G01N15/1459 , G01N2015/1006 , G01N2015/1409 , G01N2015/1413 , G01N2015/149
摘要： Provided is a microparticle measurement device that can deliver a liquid that is used in the analysis of microparticles in a stable manner. The microparticle measurement device includes a plurality of first tank units to which a liquid is supplied from the outside, and which are respectively connected in parallel, and a bulb unit that is connected to the plurality of first tank units, and which switches to a state in which it is possible to deliver the liquid to a flow channel through which microparticles flow. According to this microparticle measurement device, in addition to performing liquid delivery from a portion of first tank units, in which the replenishment of liquid has been completed, to a flow channel, it is possible to supply liquid from the outside to first tank units other than the first tank units that are delivering liquid.
摘要翻译： 本发明提供一种能够以稳定的方式输送用于微粒分析的液体的微粒测定装置。 微粒测量装置包括多个第一罐单元，从外部供给液体并且分别并联连接的第一罐单元和连接到多个第一罐单元的灯泡单元，并且切换到状态 其中可以将液体输送到微流体通过的流动通道。 根据该微粒测量装置，除了从液体的补充完成的第一罐单元的一部分进行液体输送到流路之外，还可以从外部向第一罐单元另外供给液体 比传送液体的第一个坦克单位。
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公开(公告)号：EP2801813A1
公开(公告)日：2014-11-12
申请号：EP14172013.6
申请日：2006-02-01
CPC分类号： G01N21/6428 , C12M47/04 , G01N15/1404 , G01N15/1459 , G01N2015/1409 , G01N2015/1411 , G01N2015/149
摘要： An apparatus for sorting and orienting sperm cells includes a pair of walls in confronting arrangement and forming a flow chamber having an inlet, a downstream outlet, and an intermediate detector region. The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid containing the cells to be sorted. The first and second streams have respective flow rates relative to the third stream, such that the third stream is constricted, forming a relatively narrow sample stream, so that the cells are oriented parallel to the walls. A detector detects the desired cells and a sorter downstream of the detector, sorts the desired cells from the stream.
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10.发明公开Improved flow cytometer nozzle and flow cytometer sample handling methods 有权Durchflusszytometerdüse和Durchflusszytometerprobenbehandlungsverfahren
公开(公告)号：EP2264430A3
公开(公告)日：2014-05-14
申请号：EP10182264.1
申请日：2000-11-29
申请人： XY, LLC
CPC分类号： G01N15/1404 , G01N2015/0065 , G01N2015/1006 , G01N2015/1409 , G01N2015/1413 , G01N2015/1415 , G01N2015/149 , Y10T436/101666
摘要： A flow cytometer system, comprising a sample injection tube having an injection point through which a sample may be introduced, a sheath fluid container having a bottom end and wherein said sample injection tube is located within said sheath fluid container, a sheath fluid port connected to said sheath fluid container, a first axial motion surface in a nozzle, a second axial motion surface in said nozzle, a limited maximal acceleration differentiation transition area between said first axial motion surface in said nozzle and said second axial motion surface in said nozzle wherein said limited maximal acceleration differentiation transition area is coordinated with said sample so as to be affirmatively limited to not exceed the practical capabilities of said sample over its length and an analytical system which senses below said nozzle.
摘要翻译： 已经发明了一种用于流式细胞仪的改进的喷嘴系统，用于平坦样品的高效取向和分选过程，并且专用诸如马或牛精子细胞的物品。 这种改进的喷嘴系统包括具有新颖的内表面几何形状的喷嘴（16），其可以轻轻地加速细胞并且可以在（c）喷嘴内包括椭圆形的单个扭转内表面元件，即单个扭转定向喷嘴 （6）。 椭圆形的单个扭转内表面元件（例如）（8,9,10）可以具有层流表面并且可以产生最简单的流动路径，用于施加以加速性质或取向的流体动力作用的最小力，即 单一的扭转取向力将诸如动物精子细胞的平坦样品（16）定向到正确的方向，以便在临床应用中进行分析和有效分选过程，用于研究和动物授精行业。
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