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    Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them
    3.
    发明公开
    Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them 失效
    咪唑并吡啶，咪唑，苯并噻唑，

    公开(公告)号：EP0266890A1

    公开(公告)日：1988-05-11

    申请号：EP87308663.1

    申请日：1987-09-30

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： Yanagisawa, Isao ,  Ohta, Mitsuaki ,  Koide, Tokuo ,  Shikama, Hisataka ,  Miyata, Keiji

    IPC分类号： C07D471/04 ,  A61K31/435 ,  C07D213/76

    CPC分类号： C07D213/73 ,  C07D471/04

    摘要： The present invention relates to imidazo-pyridine derivatives of formula (I) below(and pharmaceutically acceptable salts thereof) which possess H + , K +- adenosine triphosphatase inhibition activity and are useful as prophylactic and treating agents for gastric diseases; to pharmaceutical compositions containing them; and to processes for production thereof
    wherein:

    R' represents an alkenyl group having 4 to 6 carbon atoms,or an alkyl group having 1 to 10 carbon atoms which may have a cycloalkyl group substituent;
    R 2 represents a hydroxy group, a lower alkoxycarbonyl group, a lower alkyl group which may have a hydroxy, lower alkoxy, or lower alkoxycarbonyl group substituent, a phenyl group which may have a lower alkoxy group substituent or a lower acyloxyalkyl group which may have a lower acyloxy group substituent; and,
    R 3 represents a hydrogen atom, a lower alkyl group, a halogeno-Iower alkyl group, a lower alkoxyalkyl group, a hydroxy-lower alkyl group, a cyano-lower alkyl group, a mono-or di-lower alkylamino-lower alkyl group, an amino group, a mono-or di-lower alkylamino group, a nitroso group, a lower alkoxy-carbonyl group, a lower acylamino group, a lower alkylsulfonylamino group, a group of formula:
    (wherein D is NH or S, E is N or CH,and R 5 and R 6 are the same or different and selected from a hydrogen atom and lower alkyl, lower alkoxycarbonyl and phenyl groups); a group of formula:
    (wherein X is O, S or N-R 7 wherein R 7 is a sulfamoyl group, a lower acylamino group or a lower alkynyl group); or a group of formula:


    (wherein Y is O or S and R 8 is a cyano-lower alkyl group or a lower alkynyl group).

    摘要翻译： 本发明涉及具有H +，K + - 腺苷三磷酸酶抑制活性的下式（I）的咪唑并吡啶衍生物（及其药学上可接受的盐），可用作胃疾病的预防和治疗剂; 含有它们的药物组合物; 及其生产方法其中：R 1表示具有4-6个碳原子的链烯基，或可具有环烷基取代基的具有1-10个碳原子的烷基; R 2表示羟基，低级烷氧基羰基，可具有羟基，低级烷氧基或低级烷氧基羰基取代基的低级烷基，可具有低级烷氧基取代基的苯基或较低酰氧基烷基， 可具有较低的酰氧基取代基; R 3表示氢原子，低级烷基，卤代低级烷基，低级烷氧基烷基，羟基 - 低级烷基，氰基 - 低级烷基，一或二低级烷基氨基 - 低级烷基，氨基，单 - 或二 - 低级烷基氨基，亚硝基，低级烷氧基 - 羰基，低级酰基氨基，低级烷基磺酰基氨基，式：CHEM（其中 D是NH或S，E是N或CH，R 5和R 6相同或不同，选自氢原子和低级烷基，低级烷氧基羰基和苯基）。 式中的基团：其中X为O，S或N-R 7，其中R 7为氨磺酰基，低级酰氨基或低级炔基）。 或式-CH 2 -Y-R 8基团（其中Y为O或S，R 8为氰基 - 低级烷基或低级炔基）。

    4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation
    8.
    发明公开
    4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation 失效
    4,5,6,7-四氢苯并咪唑衍生物和Herstellung。

    公开(公告)号：EP0376624A1

    公开(公告)日：1990-07-04

    申请号：EP89313415.5

    申请日：1989-12-21

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： Ohta, Mitsuaki ,  Koide, Tokuo ,  Suzuki, Takeshi ,  Matsuhisa, Akira ,  Yanagisawa, Isao ,  Miyata, Keiji

    IPC分类号： C07D235/08 ,  A61K31/415 ,  C07D235/06

    CPC分类号： C07D235/06 ,  C07D235/08

    摘要： 4,5,6,7-Tetrahydrobenzimidazole derivatives (I) and salts thereof show 5-HT₃ antagonizing activity
    wherein
    R¹, R², R³ independently represent hydrogen atom, hydroxy group, a halogen atom, a lower alkyl group which may optionally be substituted with a halogen atom, a lower alkoxy group, a lower alkylthio group, an aralkyloxy group, an aryloxy group, a lower alkanoyl group, carboxy group, a lower alkoxycarbonyl group or nitro group; R⁴,R⁵ and R⁶ can each be a hydrogen atom or a lower alkyl group; and
    X is an oxygen atom or sulfur atom.

    摘要翻译： 4,5,6,7-四氢苯并咪唑衍生物（I）及其盐显示5-HT 3拮抗活性其中R 1，R 2，R 3独立地表示氢原子，羟基，卤素 低级烷氧基，低级烷硫基，芳烷氧基，芳氧基，低级烷酰基，羧基，低级烷氧基羰基或硝基的低级烷基; R 4，R 5和R 6各自可以是氢原子或低级烷基; X是氧原子或硫原子。 ð