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公开(公告)号：EP0815129B1
公开(公告)日：2011-01-05
申请号：EP96905368.5
申请日：1996-02-12
发明人： VINIK, Aaron, I. , PITTENGER, Gary, L. , RAFAELOFF, Ronit , ROSENBERG, Lawrence , DUGUID, William, P.
IPC分类号： C12N15/12 , C07K14/00 , C07K16/00 , C12N5/00 , C12N15/00 , C07H21/00 , A61K31/00 , A61K38/00 , A61K48/00 , C12Q1/68 , C12P19/34
CPC分类号： C07K14/474 , A01K2217/05 , A61K38/00 , C07K14/4733 , C07K2319/00
摘要： Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrap but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.
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公开(公告)号：EP1159965A2
公开(公告)日：2001-12-05
申请号：EP01117955.3
申请日：1994-02-18
发明人： Hodgen, Garry D.
IPC分类号： A61K31/565 , A61P15/18
CPC分类号： A61K31/565 , Y10S514/01 , Y10S514/843
摘要： The use of a progesterone receptor antagonist for the preparation of a pharmaceutical composition for preventing an oocyte from becoming fertilized without preventing ovulation or interfering with the regularity of the ovarian menstrual cycle of a mammal.
摘要翻译： 使用孕酮受体拮抗剂制备用于预防卵母细胞受精的药物组合物，而不会阻止哺乳动物排卵或干扰卵巢月经周期的规律性。
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3.发明公开ESTABLISHMENT OF TONIC OVARIAN ESTROGEN SECRETION FOR EXTENDED THERAPEUTIC REGIMENS 无效作者GnRH拮抗剂用于制备药物用于治疗性腺激素依赖疾病的用途
公开(公告)号：EP0769956A1
公开(公告)日：1997-05-02
申请号：EP95927228.0
申请日：1995-07-18
发明人： HODGEN, Gary D. , PHILIPS, Audrey
CPC分类号： A61K38/09
摘要： A regimen for the therapeutic management of a gonadal-steroid dependent condition in a mammal constitutes reducing the estrogen supply thereof by means of administration of a GnRH antagonist in an amount effective to inhibit proliferation of endometrial tissue without substantially stopping the production of endogenous estrogen. A method of determining whether the reduced estrogen supply in an individual is such that the concentration of estradiol has been suppressed to an optimized level appropriate to the therapeutic management of the gonadal-steroid dependent condition such as endometriosis in that individual by the administration of a GnRH antagonist at a given dosage level involves titering the dosage, e.g., by conducting a progesterone challenge test and optimal regimen doses of a GnRH antagonist.
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公开(公告)号：EP0686037A1
公开(公告)日：1995-12-13
申请号：EP94909721.0
申请日：1994-02-18
发明人： HODGEN, Gary D.
CPC分类号： A61K31/565 , A61K31/57 , Y10S514/01 , A61K2300/00
摘要： A method of hormone replacement therapy involves the administration of estrogen together with an amount of antiprogestin which inhibits estrogen-induced endometrial proliferation in a woman.
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公开(公告)号：EP0815129A1
公开(公告)日：1998-01-07
申请号：EP96905368.0
申请日：1996-02-12
发明人： VINIK, Aaron, I. , PITTENGER, Gary, L. , RAFAELOFF, Ronit , ROSENBERG, Lawrence , DUGUID, William, P.
CPC分类号： C07K14/474 , A01K2217/05 , A61K38/00 , C07K14/4733 , C07K2319/00
摘要： Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrap but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.
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公开(公告)号：EP0785792A1
公开(公告)日：1997-07-30
申请号：EP95910179.0
申请日：1995-02-02
CPC分类号： A61K38/09 , Y10S514/01 , A61K31/565 , A61K2300/00
摘要： A method of treating an ovarian estrogen dependent condition such as endometriosis, uterine leiomyomata, PMS or DUB involving the administration of gonadotropin releasing hormone analog and the administration of antiprogestin, which will provide a therapeutic method for long term treatment without rapid loss of bone density, as occurs using GnRH analogs alone.
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公开(公告)号：EP1207797B1
公开(公告)日：2008-02-13
申请号：EP00955350.4
申请日：2000-08-02
申请人： Eastern Virginia Medical School of the Medical College of Hampton Roads , Old Dominion University Research Foundation
IPC分类号： A61B18/12
CPC分类号： A61B18/1206
摘要： A method for intracellular electro-manipulation is provided. The method includes applying one or more ultrashort electric field pulse to target cells. The ultrashort electric field pulses have sufficient amplitude and duration to modify subcellular structures in the target cells and do not exceed the breakdown field of the medium containing the target cells. The amplitude and duration of the ultrashort electric field pulse are typically insufficient to substantially alter permeability of the surface membranes of the target cells, e.g., by irreversibly disrupting the cell surface membranes. An apparatus for intracellular electro-manipulation is also provided. The apparatus includes a pulse generator capable of producing an ultrashort electric pulse output and a delivery system capable of directing the electric pulse output to target cells.
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公开(公告)号：EP1007647B1
公开(公告)日：2004-05-06
申请号：EP97912942.6
申请日：1997-10-30
CPC分类号： C07K14/4733 , C07K2319/00
摘要： Removal of the nucleotide sequence encoding the signal peptide from the INGAP coding sequence allows bacteria to express substantial amounts of INGAP activity. Previous attempts have provided only low yields of INGAP, possibly because the signal sequence of INGAP is toxic to bacteria.
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9.发明授权The use of a gonadotropin releasing hormone analog or mime thereof for the preparation of a pharmaceutical composition as an adjunctive for the invasive treatment of carcinomas 无效促性腺激素释放激素类似物或änlichen化合物用于制备药物制剂作为用于癌的侵入性治疗的添加剂的使用
公开(公告)号：EP0796622B1
公开(公告)日：2003-09-10
申请号：EP97104590.1
申请日：1997-03-18
发明人： Hodgen, Gary D.
CPC分类号： A61K38/09 , Y10S514/80
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公开(公告)号：EP0686037B1
公开(公告)日：2001-06-20
申请号：EP94909721.6
申请日：1994-02-18
发明人： HODGEN, Gary D.
IPC分类号： A61K31/56
CPC分类号： A61K31/565 , A61K31/57 , Y10S514/01 , A61K2300/00
摘要： A method of hormone replacement therapy involves the administration of estrogen together with an amount of antiprogestin which inhibits estrogen-induced endometrial proliferation in a woman.
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