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1.发明公开
公开(公告)号：EP3048107A1
公开(公告)日：2016-07-27
申请号：EP14845080.2
申请日：2014-08-29
申请人： UBE Industries, Ltd.
发明人： TOKITO, Shizuo , KUMAKI, Daisuke , MAMADA, Masashi , FUKUDA, Kenjiro , TANAKA, Yasuhiro , SHIMA, Hidetaka , YONEDA, Yasuhiro , FUJITA, Harunori , KAKITA, Kazuaki , OMATA, Youji , YAMADA, Natsuko , HONMA, Takashi , MACHIDA, Toshikazu
IPC分类号： C07D513/04 , H01L29/786 , H01L51/05 , H01L51/30 , H01L51/46 , H01L51/50
CPC分类号： H01L51/0071 , C07D513/02 , C07D513/04 , C09D11/52 , H01L27/3274 , H01L51/0068 , H01L51/0097 , H01L51/0558 , H01L51/0566 , H01L51/4253 , H01L51/5056 , H01L51/5072 , Y02E10/549
摘要： The present invention relates to a benzobis(thiadiazole) derivative represented by the following general formula (1):
wherein
R 1 represents a linear or branched alkyl group, or any one of the groups of the following formula (2):
wherein R represents a linear or branched alkyl group;
R 2 represents a hydrogen atom; and
R 3 represents a hydrogen atom, a linear or branched alkyl group, or any one of the groups of the formula (2);
with the proviso that
at least one of R 1 and R 3 represents any one of the groups of the formula (2); and
two R 1 groups, two R 2 groups, and two R 3 groups may be the same as, or different from each other.-
公开(公告)号：EP1467978A1
公开(公告)日：2004-10-20
申请号：EP02805675.2
申请日：2002-12-20
IPC分类号： C07D265/12 , C07D279/08 , A61K31/5365 , A61K31/542 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： C07D513/04 , A61K31/5365 , A61K31/542 , C07D333/38 , C07D409/12 , C07D498/02 , C07D513/02
摘要： The subject invention features compounds having the structure:, wherein X is O, S, CH2 or NR5; Y is O or S; R1 is H, substituted or unsubstituted C1C15 alkyl, C1-C8 alkylaryl, -C(O)OR4, -C(O)NR4R5, -CR6R6'OR4,-CR6R6'OC(O)R4, - CR6R6'OC(O)NHR7, -C(O)NR1oR11, -C(O)NR8R9 NR8R9, -N(R5)C(O)NHR5, or CH2R4; R2 is a substituted or unsubstituted, straight chain C1-C30 alkyl or branched C3 C30 alkyl, aryl, alkylaryl, arylalkyl, heteroarylalkyl or cycloalkyl; R3 is H or substituted or unsubstituted C1-C6 alkyl or C3-C10 cycloalkyl; R4 is H or a substituted or unsubstituted, straight chain or branched, C6-C30 alkyl, aryl, -CH2-aryl, aryl -C1-C15 alkyl, heteroaryl-C1-C15alkyl or C3-C10 cycloalkyl; R5 is H or a substituted or unsubstituted, straight chain or branched, C6-C30 alkyl, aryl C1-C30alkyl, heteroarylalkyl or cycloalkyl; R6 and R6' are each independently H, substituted or unsubstituted C1-C6 alkyl, dialkyl or C3-C10 cycloalkyl or together form a 3-7 membered ring system; R7 is H or substituted or unsubstituted C1-C12 alkyl or C3-C10 cycloalkyl; R8 and R9 are each independently H, substituted or unsubstituted C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylaryl, or NR8R9 together form a substituted piperazine or piperidine ring or a dihydro-1H-isoquinoline ring system, or a specific enantiomer thereof, or a specific tautomer, or a pharmaceutically acceptable salt thereof and a method for treating diabetes or obesity by administering a therapeutically effective amount of the compounds of the invention.
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3.发明公开CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS 审中-公开氨基化合物，药物组合物时AND METHOD FOR抑制（B）淀粉样肽释放和/或其合成这些化合物的使用
公开(公告)号：EP1093372A4
公开(公告)日：2004-09-29
申请号：EP99930600
申请日：1999-06-22
申请人： ELAN PHARM INC , LILLY CO ELI
发明人： AUDIA JAMES E , DRESSMAN BRUCE A , SHI QING
IPC分类号： A61K38/00 , A61K31/55 , A61P25/28 , A61P43/00 , C07D223/14 , C07D223/16 , C07D223/18 , C07D243/06 , C07D243/10 , C07D243/12 , C07D243/14 , C07D243/24 , C07D267/02 , C07D267/14 , C07D281/02 , C07D281/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D471/04 , C07D471/06 , C07D471/08 , C07D487/02 , C07D487/04 , C07D487/12 , C07D498/02 , C07D513/02 , C07K4/00
CPC分类号： A61K31/55 , A61K38/00 , C07D223/14 , C07D223/16 , C07D223/18 , C07D243/06 , C07D243/10 , C07D243/12 , C07D243/14 , C07D243/24 , C07D267/02 , C07D267/14 , C07D281/02 , C07D281/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D471/04 , C07D471/06 , C07D471/08 , C07D487/02 , C07D487/04 , C07D487/12 , C07D498/02 , C07D513/02 , C07K4/00
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4.发明公开BENZOBIS (THIADIAZOLE) DERIVATIVE, INK CONTAINING SAME, AND ORGANIC ELECTRONIC DEVICE USING SAME 审中-公开BENZOBIS-THIADIAZOLDERIVAT，TINTE DAMIT UND ORGANISCHE ELEKTRONISCHE VORRICHTUNG DAMIT
公开(公告)号：EP3048107A4
公开(公告)日：2017-05-31
申请号：EP14845080
申请日：2014-08-29
申请人： UBE INDUSTRIES
发明人： TOKITO SHIZUO , KUMAKI DAISUKE , MAMADA MASASHI , FUKUDA KENJIRO , TANAKA YASUHIRO , SHIMA HIDETAKA , YONEDA YASUHIRO , FUJITA HARUNORI , KAKITA KAZUAKI , OMATA YOUJI , YAMADA NATSUKO , HONMA TAKASHI , MACHIDA TOSHIKAZU
IPC分类号： H01L51/30 , C07D513/02 , C07D513/04 , C09D11/52 , H01L27/32 , H01L29/786 , H01L51/46 , H01L51/54
CPC分类号： H01L51/0071 , C07D513/02 , C07D513/04 , C09D11/52 , H01L27/3274 , H01L51/0068 , H01L51/0097 , H01L51/0558 , H01L51/0566 , H01L51/4253 , H01L51/5056 , H01L51/5072 , Y02E10/549
摘要： The present invention relates to a benzobis(thiadiazole) derivative represented by the following general formula (1): wherein R 1 represents a linear or branched alkyl group, or any one of the groups of the following formula (2): wherein R represents a linear or branched alkyl group; R 2 represents a hydrogen atom; and R 3 represents a hydrogen atom, a linear or branched alkyl group, or any one of the groups of the formula (2); with the proviso that at least one of R 1 and R 3 represents any one of the groups of the formula (2); and two R 1 groups, two R 2 groups, and two R 3 groups may be the same as, or different from each other.
摘要翻译： 本发明涉及下述通式（1）所示的苯并双（噻二唑）衍生物，式中，R 1表示直链状或支链状的烷基或下述式（2）的基团中的任一种：式中，R表示 直链或支链烷基; R 2代表氢原子; 并且R 3表示氢原子，直链或支链烷基或式（2）的任何一个基团; 条件是R 1和R 3中的至少一个表示式（2）的任何一个基团; 并且两个R 1基团，两个R 2基团和两个R 3基团可以彼此相同或不同。
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公开(公告)号：EP2451793A1
公开(公告)日：2012-05-16
申请号：EP10731890.9
申请日：2010-07-06
发明人： AUDIA, James, Edmund , MERGOTT, Dustin, James , SHI, Chongsheng, Eric , VAUGHT, Grant, Mathews , WATSON, Brian, Morgan , WINNEROSKI, Leonard, Larry, Jr.
IPC分类号： C07D279/08 , C07D498/04 , C07D513/02
CPC分类号： C07D513/02 , C07D279/08 , C07D498/04
摘要： The present invention provides BACE inhibitors of Formula I: methods for their use, intermediates, and methods for their preparation.
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公开(公告)号：EP3212792A1
公开(公告)日：2017-09-06
申请号：EP15853804.1
申请日：2015-10-29
申请人： Biotium, Inc.
发明人： MAO, Fei , MCGARRAUGH, Patrick, Gordon , MADRID, Alexis, Spain , LEUNG, Wai-Yee , ROBERTS, Lori, M.
CPC分类号： C12Q1/689 , C07D221/08 , C07D221/12 , C07D513/02 , C07D513/14 , C12Q1/68 , C12Q1/6809 , C12Q1/6816 , C12Q2563/107 , C12Q2563/131 , C12Q2563/173
摘要： In some aspects, the disclosure provides compounds comprising nucleic acid modifying moieties, such as nucleic acid binding dyes comprising activatable groups. In some aspects, the disclosure provides nucleic acid probes comprising compounds of the disclosure, and methods of making the same. In some aspects, the disclosure provides methods of using compounds of the disclosure, such as methods of labeling and/or detecting non-viable organisms or non-viable cells, and methods of detecting contamination or infection.
摘要翻译： 在一些方面，本公开提供了包含核酸修饰部分的化合物，例如包含可活化基团的核酸结合染料。 在一些方面，本公开提供了包含本公开化合物的核酸探针及其制备方法。 在一些方面，本公开提供了使用本公开内容的化合物的方法，例如标记和/或检测非活细胞或非活细胞的方法，以及检测污染或感染的方法。
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公开(公告)号：EP1467978A4
公开(公告)日：2005-11-02
申请号：EP02805675
申请日：2002-12-20
申请人： OSI PHARM INC
发明人： WITTER DAVID , CASTELHANO ARLINDO L
IPC分类号： A61K31/519 , A61K31/5365 , A61K31/542 , A61P3/04 , A61P3/06 , A61P3/10 , A61P43/00 , C07B61/00 , C07D333/38 , C07D333/40 , C07D409/12 , C07D495/04 , C07D498/02 , C07D498/04 , C07D513/02 , C07D513/04 , C07D265/12 , C07D279/08
CPC分类号： C07D513/04 , A61K31/5365 , A61K31/542 , C07D333/38 , C07D409/12 , C07D498/02 , C07D513/02
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公开(公告)号：EP2451793B1
公开(公告)日：2016-11-02
申请号：EP10731890.9
申请日：2010-07-06
发明人： AUDIA, James, Edmund , MERGOTT, Dustin, James , SHI, Chongsheng, Eric , VAUGHT, Grant, Mathews , WATSON, Brian, Morgan , WINNEROSKI, Leonard, Larry, Jr.
IPC分类号： C07D279/08 , C07D498/04 , C07D513/02
CPC分类号： C07D513/02 , C07D279/08 , C07D498/04
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9.发明公开
公开(公告)号：EP2794592A1
公开(公告)日：2014-10-29
申请号：EP12805897.1
申请日：2012-12-12
申请人： Novartis AG
IPC分类号： C07D401/10 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/02 , A61K31/4725 , A61K31/513 , A61K31/519 , A61K31/506 , A61K31/501 , A61P35/00
CPC分类号： C07D513/04 , A61K31/4725 , A61K31/4745 , A61K31/501 , A61K31/513 , A61K31/519 , A61K31/5377 , C07D401/10 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/02
摘要： The present invention relates to compounds of formula I: in which R
1 , R
2 , R
3 and R
4 are as defined in the Summary of the Invention. Compounds of formula I are capable of disrupting the BCL-2 interations with proteins containing a BH3 domain. Disrupting this interaction can restore the anti-apoptotic function of BCL-2 in cancer cells and tumor tissue expressing BCL-2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancerous diseases.-
10.发明公开CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS 审中-公开氨基化合物，药物组合物时AND METHOD FOR抑制（B）淀粉样肽释放和/或其合成这些化合物的使用
公开(公告)号：EP1093372A1
公开(公告)日：2001-04-25
申请号：EP99930600.4
申请日：1999-06-22
发明人： AUDIA, James, E. , DRESSMAN, Bruce, A. , SHI, Qing
IPC分类号： A61K31/55 , C07D223/14 , C07D243/06 , C07D243/10 , C07D243/12 , C07D243/24 , C07D267/02 , C07D281/02 , C07D487/02 , C07D487/12 , C07D498/02 , C07D513/02
CPC分类号： A61K31/55 , A61K38/00 , C07D223/14 , C07D223/16 , C07D223/18 , C07D243/06 , C07D243/10 , C07D243/12 , C07D243/14 , C07D243/24 , C07D267/02 , C07D267/14 , C07D281/02 , C07D281/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D471/04 , C07D471/06 , C07D471/08 , C07D487/02 , C07D487/04 , C07D487/12 , C07D498/02 , C07D513/02 , C07K4/00
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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