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公开(公告)号：EP3404102A1
公开(公告)日：2018-11-21
申请号：EP18173111.8
申请日：2005-04-21
CPC分类号： C07K7/06 , A61K38/00 , A61K47/645 , C07K14/51 , C07K2319/01 , C07K2319/23 , C12N9/16 , C12N9/6421 , C12N9/6494 , C12Y301/03001 , C12Y304/24011
摘要： The invention relates to a pharmaceutical composition comprising a bone delivery conjugate having the structure Z-sALP-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; Dn is a poly aspartate, wherein n=10 to 16; and sALP is a soluble alkaline phosphatase and uses thereof.
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2.发明授权
公开(公告)号：EP1964573B1
公开(公告)日：2014-11-26
申请号：EP08009203.4
申请日：2000-10-20
发明人： Berinstein, Neil , Tartaglia, James, c/o Sanofi Pasteur , Moingeon, Philippe , Barber, Brian, University Health Network
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
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3.发明公开
公开(公告)号：EP1964573A3
公开(公告)日：2011-03-02
申请号：EP08009203.4
申请日：2000-10-20
发明人： Berinstein, Neil , Tartaglia, James, c/o Sanofi Pasteur , Moingeon, Philippe , Barber, Brian, University Health Network
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.
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4.发明公开NOVEL USES OF SODIUM 4-PHENYLBUTYRATE (4 PBA) AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF 审中-公开4-苯基丁酸钠（4 PBA）和药学上可接受的盐的新用途
公开(公告)号：EP2272515A1
公开(公告)日：2011-01-12
申请号：EP09719846.9
申请日：2009-03-06
发明人： FRECHILLA MANSO, Diana Sara , GARCÍA OSTA, Ana Maria , PÉREZ MEDIAVILLA, Luis Alberto , RICOBARAZA ABARQUERO, Ana Lourdes
CPC分类号： A61K38/4886 , A61K31/06 , A61K31/192 , A61K31/47 , A61K38/25 , A61K45/06 , C12Y304/24011 , A61K2300/00
摘要： Novel uses for 4-phenylbutyrate (4PBA) and Its pharmaceutically acceptable salts
The use of 4PBA in the manufacture of a medicament useful to treat cognitive disorders in dementias coursing with tauopathies is described.
The treatment with 4PBA improves cognitive deficit in a classic murine experimental model of Alzheimer's Disease (AD) (Tg 2576) that is accompanied by decreasing levels of a marker characteristic to AD pathologies, such as phosphorylated Tau, and increasing levels in the synthesis of some synaptic plasticity marker proteins such as GluR1 and PSD95. As mediating mechanism for the therapeutic effect we propose a decreasing stress in the endoplasmic reticulum as manifested by increasing levels of the GRP78 protein. On the other hand its inhibiting effect on histone deacetylation and its involvement in chromatin remodeling facilitates protein synthesis processes, which improves synaptic plasticity.摘要翻译： 新用途4-苯（4PBA）及其药学上可接受的盐在制备药物有用的制造过程中使用的4PBA与tau蛋白病痴呆窃喜被描述为治疗认知障碍。 用4PBA治疗改善在阿尔茨海默病（AD）（TG 2576）的一个典型的鼠的实验模型中的认知缺陷确实伴随着降低的标记物特征的水平到AD的病理，检查如磷酸化tau和增加水平的某些合成 突触可塑性标记蛋白：如的GluR1和PSD95。 作为中介机构的治疗效果我们提出了一个降低应力的内质网由增加GRP78蛋白的水平表现出来。 在另一方面其抑制组蛋白脱乙酰化及其在染色质重塑参与便于蛋白质的合成方法，从而提高突触可塑性效果。
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5.发明公开
公开(公告)号：EP1227837A1
公开(公告)日：2002-08-07
申请号：EP00971184.7
申请日：2000-10-20
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.
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公开(公告)号：EP2598631A1
公开(公告)日：2013-06-05
申请号：EP11811675.5
申请日：2011-07-28
IPC分类号： C12N1/21 , A61K39/295 , A61P31/04 , A61P31/12 , A61P37/04 , C12N15/00 , C12N15/74 , C07K14/255 , C07K19/00
CPC分类号： C07K14/77 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K2039/522 , A61K2039/523 , C07K14/195 , C07K14/4713 , C07K14/4748 , C07K14/70596 , C07K14/71 , C07K2319/036 , C07K2319/35 , C12N1/20 , C12N9/0059 , C12N9/2462 , C12N9/6494 , C12N2760/10034 , C12Y110/03001 , C12Y304/24011 , Y02A50/41
摘要： The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type III secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen, a bacterial antigen, or a tumour antigen. Methods of imparting immunity using the recombinant bacterium are also provided.
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公开(公告)号：EP2442824A2
公开(公告)日：2012-04-25
申请号：EP10728527.2
申请日：2010-06-21
申请人： MedImmune, LLC
发明人： WEBSTER, Carl, Innes , JERMUTUS, Lutz, Ulrich, Jochen, Wilhelm , BIRKENFELD, Jorg , EICKER, Andrea , FRESKGARD, Per-Ola , GOTZBERGER-SCHAD, Claudia , GRUDZINSKA, Joanna , HAUPTS, Ulrich , INNIG, Josi , MAHLERT, Christoph , SCHEIDIG, Andreas , STRERATH, Michael , TEBBE, Jan , WALLIN, Johan, Per , WOBST, Nina
CPC分类号： C12N9/6494 , A61K38/00 , C12Y304/24011
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8.发明公开Bone delivery conjugates and method of using same to target proteins to bone 有权结合物为他们的蛋白质的铅的使用，以提供Knochem骨和程序
公开(公告)号：EP2348114A1
公开(公告)日：2011-07-27
申请号：EP11000196.3
申请日：2005-04-21
申请人： Enobia Pharma Inc.
CPC分类号： C07K7/06 , A61K38/00 , A61K47/645 , C07K14/51 , C07K2319/01 , C07K2319/23 , C12N9/16 , C12N9/6421 , C12N9/6494 , C12Y301/03001 , C12Y304/24011
摘要： A bone delivery conjugate having a structure selected from the group consisting of :A) X-D n -Y-protein-Z; and B) Z-protein-Y- D n -X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and D n is a poly aspartate wherein n = 10 to 16. Compositions comprising same and uses thereof.
摘要翻译： 选自的选择具有结构的骨递送轭合物：A）X-DN-Y-蛋白-Z; 和B）Z-蛋白-Y- DN -X，worin X不存在或者是至少一个氨基酸的氨基酸序列; Y不存在或者是至少一个氨基酸的氨基酸序列; Z不存在或者是至少一个氨基酸的氨基酸序列; 和D n是聚天冬氨酸worin N = 10〜16的组合物，其包括相同的和其用途。
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9.发明授权
公开(公告)号：EP1759001B1
公开(公告)日：2011-04-13
申请号：EP05739065.0
申请日：2005-04-21
申请人： Enobia Pharma Inc.
CPC分类号： C07K7/06 , A61K38/00 , A61K47/645 , C07K14/51 , C07K2319/01 , C07K2319/23 , C12N9/16 , C12N9/6421 , C12N9/6494 , C12Y301/03001 , C12Y304/24011
摘要： A bone delivery conjugate having a structure selected from the group consisting of :A) X-D n -Y-protein-Z; and B) Z-protein-Y- D n -X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and D n is a poly aspartate wherein n = 10 to 16. Compositions comprising same and uses thereof.
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10.发明公开Method of inducing and/or enhancing an immune response to tumor antigens 有权Verfahren zur Induzierung und / oder Verbesserung einer Immunreaktion auf Tumorantigene
公开(公告)号：EP1964573A2
公开(公告)日：2008-09-03
申请号：EP08009203.4
申请日：2000-10-20
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/6494 , C12N15/86 , C12N2710/24043 , C12N2710/24071 , C12Y304/24011
摘要： An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.
摘要翻译： 公开了诱导和/或增强对肿瘤抗原的免疫应答的改进方法。 该方法包括将肿瘤抗原，其编码的核酸，包含所述核酸的载体和/或细胞或包含上述的疫苗施用于淋巴结位点。
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