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公开(公告)号：EP4386081A3
公开(公告)日：2024-10-16
申请号：EP24169043.7
申请日：2020-05-20
发明人： SHARON, Nadav , MELTON, Douglas, A.
摘要： Disclosed herein are methods for directing a differentiation protocol to produce cells of a desired cell fate, such as SC-β and/or SC-α cells.
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公开(公告)号：EP1993575B1
公开(公告)日：2019-07-03
申请号：EP07789615.7
申请日：2007-03-06
申请人： Shroff, Geeta
发明人： Shroff, Geeta
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公开(公告)号：EP2495311B1
公开(公告)日：2019-03-13
申请号：EP09850889.8
申请日：2009-10-28
申请人： SNU R&DB Foundation
发明人： KIM, Hyo Soo , KANG, Hyun Jae , LEE, Eun Ju , PARK, Young Bae
IPC分类号： C12N5/0775 , C12N5/02 , A61K35/48 , C12N5/0735
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5.发明授权
公开(公告)号：EP2854825B1
公开(公告)日：2018-10-31
申请号：EP13727699.4
申请日：2013-05-14
发明人： KIHM, Anthony J.
CPC分类号： A61K35/51
摘要： This invention encompasses methods, pharmaceutical compositions, and kits for modulating (e.g. reducing) the production of pro-inflammatory mediators involved in the pathology of a lung disease, disorder, and/or injury in a patient having the lung disease, disorder, and/or injury. The invention also encompasses methods, pharmaceutical compositions, and kits for inhibiting the production of pro-inflammatory mediators involved in the pathology of a lung disease, disorder, and/or injury in a patient having the lung disease, disorder, and/or injury. In one embodiment, the umbilical cord tissue-derived cells are isolated from human umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, lack the production of CD117 or CD45, and do not express hTERT or telomerase.
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公开(公告)号：EP3154557A4
公开(公告)日：2018-04-25
申请号：EP15810063
申请日：2015-06-15
申请人： AMNIO TECH LLC
CPC分类号： A61K35/50 , A61K8/982 , A61K35/28 , A61K35/35 , A61K35/44 , A61M2037/0061 , A61Q19/08 , A61K2300/00
摘要： Acellular amnion derived therapeutic compositions are described having a number of various compositional embodiments. An acellular amnion derived therapeutic composition has essentially no live or active amniotic stems cells. The amniotic stem cells may be destroyed, and the cells and cell debris may be removed from the acellular amnion derived therapeutic composition. An acellular amnion derived therapeutic composition may comprise micronized amniotic membrane particles, and/or amniotic fluid. An acellular amnion derived therapeutic composition may be a dispersion of micronized amniotic membrane combined with a fluid, such as plasma, saline, amniotic fluid, combinations thereof and the like. An acellular amnion derived therapeutic composition may be combined with a matrix component to form a composite. An acellular amnion derived therapeutic composition may be used in conjunction with a composition comprising viable cells, such as stem cells.
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7.发明公开SINGLE CHAIN IL-12 NUCLEIC ACIDS, POLYPEPTIDS, AND USES THEREOF 审中-公开EINKETTIGE IL-12NUKLEINSÄUREN，POLYPEPTIDE UND VERWENDUNGEN DAVON
公开(公告)号：EP3083666A4
公开(公告)日：2017-09-20
申请号：EP14871160
申请日：2014-12-17
申请人： INTREXON CORP
IPC分类号： C07K14/54 , A61K31/7088 , A61K35/26 , A61K35/28 , A61K35/48 , A61K35/545 , A61K38/00 , A61K38/20 , A61P35/00 , C12N5/0783 , C12N15/24 , C12N15/861
CPC分类号： C07K14/5434 , A61K31/7088 , A61K35/26 , A61K35/28 , A61K35/48 , A61K35/545 , A61K38/00 , C07K2319/00
摘要： The present invention relates to novel single chain interleukin-12 polypeptides. The invention also relates to isolated nucleic acids encoding the single chain interleukin-12 polypeptides, to vectors and cells comprising them, and to their uses, in particular in methods of using single chain IL-12 polypeptides, polynucleotides, vectors and cells of the invention for enhancing immune system function, for example as vaccine adjuvants and in the treatment of infections and cancer.
摘要翻译： 本发明涉及新型单链白细胞介素-12多肽。 本发明还涉及编码单链白细胞介素-12多肽的分离的核酸，涉及包含它们的载体和细胞，及其用途，特别是在使用本发明的单链IL-12多肽，多核苷酸，载体和细胞的方法中 用于增强免疫系统功能，例如作为疫苗佐剂以及用于治疗感染和癌症。
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8.发明授权TREATMENT OF INTERVERTEBRAL DISC DEGENERATION USING HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS AND HYDROGEL 有权治疗细胞人脐带组织和水凝胶的椎间盘退变基础探讨
公开(公告)号：EP2709637B1
公开(公告)日：2017-03-22
申请号：EP12725939.8
申请日：2012-05-17
IPC分类号： A61K38/18 , A61K38/17 , A61K35/51 , A61K35/12 , A61K35/50 , A61L27/22 , A61L27/38 , A61L27/54 , C12N5/073 , A61K35/48 , A61L27/52 , A61P29/00
CPC分类号： A61L27/3878 , A61K35/12 , A61K35/50 , A61K35/51 , A61K38/1774 , A61K38/1841 , A61K38/1858 , A61L27/225 , A61L27/227 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/38 , C12N5/0605
摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells and optionally a hydrogel. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
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9.发明公开COMPOSITIONS AND METHODS FOR GENETIC ANALYSIS OF EMBRYOS 审中-公开ZUSAMMENSETZUNGEN UND VERFAHREN ZUR GENETICHCH分析师VON EMBRYONEN
公开(公告)号：EP2958574A4
公开(公告)日：2016-11-02
申请号：EP14743593
申请日：2014-01-23
发明人： JOHNSON MARK T
CPC分类号： C12Q1/6883 , C12Q1/6869 , C12Q2600/156 , C12Q2600/158 , C12Q2537/16
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10.发明公开
公开(公告)号：EP2866816A4
公开(公告)日：2016-03-16
申请号：EP13797216
申请日：2013-05-31
发明人： LASHKARI KAMERAN , YOUNG MICHAEL , EMINLI SARAH , MARASCO WAYNE , PRETI ROBERT A
IPC分类号： A61K35/28 , A61K35/12 , A61K35/48 , A61K35/545 , A61P27/00
CPC分类号： A61K35/545 , A61K9/0048 , A61K45/06
摘要： The present invention relates to use of very small embryonic-like (VSEL) stem cells in therapies for ocular disease involving retinal degeneration or dysfunction. The invention also included pharmaceutical compositions made with VSELs which may be used to restore lost vision or reduce or halt vision loss due to diseases or disorders of the retina, or other diseases or retinal injuries that would benefit from stem cell replacement therapy.
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