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公开(公告)号：EP4461319A1
公开(公告)日：2024-11-13
申请号：EP24172577.9
申请日：2024-04-25
IPC分类号： A61K51/00
摘要： Systems (100), devices and methods for internal dose adapted automated external radiation beam therapy, and systems (220) and methods for an automated adaptive workflow to automatically generate a radiation treatment plan (400B) based on the internal dose (310) and adapt the treatment plan to a current treatment session using a set of directives (230).
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公开(公告)号：EP4430044A1
公开(公告)日：2024-09-18
申请号：EP22821313.8
申请日：2022-11-10
申请人： AC Immune SA
发明人： MOLETTE, Jérôme
IPC分类号： C07D487/04 , A61K31/4162 , A61K51/00
CPC分类号： C07D487/04
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公开(公告)号：EP3693391B1
公开(公告)日：2024-08-21
申请号：EP19219511.3
申请日：2015-09-11
CPC分类号： C07K2317/2420130101 , C07K2317/3420130101 , C07K2317/5220130101 , C07K2317/7720130101 , C07K2317/9420130101 , A61K47/6889 , A61K47/68 , A61K47/6817 , A61K47/6867 , A61K31/5517 , A61K31/706 , A61K51/1069 , A61K51/1093 , C07K16/2851 , C07K16/3061 , C07K2317/3320130101 , C07K2317/9220130101 , A61P35/00 , A61P35/02 , A61K2039/50520130101
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公开(公告)号：EP4376899A1
公开(公告)日：2024-06-05
申请号：EP22848759.1
申请日：2022-04-20
发明人： DEKEMP, Robert A.
CPC分类号： A61K51/00 , A61K49/0002 , A61B6/037 , A61B6/503 , A61B6/481 , A61B6/5258 , A61B6/54
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公开(公告)号：EP4361159A1
公开(公告)日：2024-05-01
申请号：EP22828062.4
申请日：2022-04-20
发明人： MURATA,Yusuke , TAKENAKA,Hiroshi , OHTA,Yoichiro , SUDANI,Aya , ISHIMURA,Miki , SUZUKI,Kensuke , KAI,Hiroyuki
摘要： Provided are new compounds that can have the property of being specifically taken up into cancer cells. In the present invention, novel 4-borono-phenylalanine derivatives, borono-phenylalanine derivatives having a heterocyclic skeleton, borono-phenylalanine derivatives having a fused ring structure, or pharmaceutically acceptable salts thereof are prepared. These compounds have the property of being taken up specifically by LAT1 and thus easily taken up specifically by cancer cells in the evaluation of LAT1 and LAT2 selective uptake, and can be conveniently used for neutron capture therapy and the like. A typical example is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4327831A1
公开(公告)日：2024-02-28
申请号：EP22791751.5
申请日：2022-04-20
IPC分类号： A61K47/68 , A61K39/395 , A61K45/00 , A61K47/60 , A61K47/69 , A61K51/00 , A61K51/02 , A61K51/10 , A61P35/00 , C07K4/00 , C07K16/28
摘要： The present invention aims to provide a conjugate having stability improved more than conventional conjugates without impairing the efficacy. The conjugate of the present invention is a conjugate of an anti-CD20 antibody and a chelating agent, wherein the chelating agent is chelated with a metal radionuclide, the anti-CD20 antibody and the chelating agent are linked by a linker (L), and the linker (L) does not contain a thiourea bond.
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7.发明公开
公开(公告)号：EP4313049A1
公开(公告)日：2024-02-07
申请号：EP22782372.1
申请日：2022-04-04
发明人： RAY, Sangeeta Banerjee , BOINAPALLY, Srikanth , POMPER, Martin Gilbert , HORTI, Andrew , DAS, Deepankar , MINN, Il , CARROLL, Laurence , CHA, Hyojin
IPC分类号： A61K31/4709 , A61K51/00 , A61K51/04
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8.发明授权
公开(公告)号：EP3530648B1
公开(公告)日：2023-11-08
申请号：EP18198896.5
申请日：2007-12-17
发明人： TOYAMA, Masahito , HAYASHI, Akio
IPC分类号： C07C303/28 , C07C303/44 , C07C309/65 , A61K51/00 , C07B59/00 , G01T1/161 , C07C309/73 , G21H5/02
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公开(公告)号：EP4218831A1
公开(公告)日：2023-08-02
申请号：EP21871944.1
申请日：2021-07-08
发明人： SUZUKI Hisashi , YOSHII Yukie
IPC分类号： A61K51/00 , B01D1/00 , B01D3/36 , A61K103/00
摘要： The present invention is a method for evaporatively concentrating a radioactive metal nuclide, including: a first evaporative concentration process in which a radioactive solution formed by dissolving a radioactive metal nuclide in an acidic aqueous solution is heated to evaporate a solvent in the radioactive solution so as to obtain a concentrated liquid containing the radioactive metal nuclide; and a second evaporative concentration process in which a low-boiling organic solvent having a lower boiling point than water is added to the concentrated liquid, and the concentrated liquid is heated to induce azeotropic boiling of the concentrated liquid and the low-boiling organic solvent so as to obtain an evaporative concentrate of the radioactive metal nuclide. According to the present invention, it is possible to perform, without manual intervention, the processing from the separation of a radioactive metal nuclide from a radioactive solution formed by dissolving the radioactive metal nuclide in an acidic aqueous solution, to the production of a radioactive labeled substance by causing the radioactive metal nuclide to react with a label-target compound.
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公开(公告)号：EP4184528A1
公开(公告)日：2023-05-24
申请号：EP21842595.7
申请日：2021-07-13
发明人： HONDA, Yoshio , NATSUSAKO, Masashi , ASO, Shunichi
摘要： A method for producing 225 Ac solution includes steps (I) to (III): a step (I) of passing a solution (1) containing 226 Ra and 225 Ac through a solid-phase extraction agent (a) that contains a compound represented by formula (A) so as to cause the solid-phase extraction agent (a) to retain 225 Ac; a step (II) of passing a liquid containing an eluate (2), which is obtained by eluting the retained 225 Ac from the solid-phase extraction agent (a), through a solid-phase extraction agent (b) that contains a compound represented by formula (B) so as to cause the solid-phase extraction agent (b) to retain 225 Ac; and a step (III) of eluting the retained 225 Ac from the solid-phase extraction agent (b) to obtain an 225 Ac solution.
[m and n each independently represent 0 or 1, and R 1 to R 4 each independently represent a linear or branched C8-C12 alkyl group.]
[R 5 and R 6 each independently represent a C8 alkyl group or a C8 alkoxy group.]
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