公开(公告)号：EP4455147A1

公开(公告)日：2024-10-30

申请号：EP22910205.8

申请日：2022-12-23

申请人： Genfleet Therapeutics (Shanghai) Inc. ,  Zhejiang Genfleet Therapeutics Co., Ltd.

发明人： ZHOU, Fusheng ,  ZHAO, Jinzhu ,  CAO, Yudong ,  XIONG, Lun ,  SHI, Rongzhen ,  LAN, Jiong

IPC分类号： C07D487/22 ,  A61K31/4985 ,  A61P35/00

摘要： Provided are a polymorph of a KRAS inhibitor, a preparation method therefor, and a use thereof. Specifically disclosed is a pharmaceutically acceptable salt of a compound 1 or a polymorph of the compound or pharmaceutically acceptable salt thereof, and further disclosed are a preparation method for the salt or polymorph and an application of the salt or polymorph in the treatment and/or prevention of KRAS G12C mutation-related diseases.

公开(公告)号：EP3651588B1

公开(公告)日：2024-03-13

申请号：EP18753277.5

申请日：2018-07-10

发明人： KENDRICK, Andrew ,  THORPE, Stuart, David

IPC分类号： A23L2/58 ,  C07D487/22 ,  A23L5/43 ,  C09B61/00 ,  C09B67/42 ,  C09B67/54 ,  C12C5/04

公开(公告)号：EP4319823A1

公开(公告)日：2024-02-14

申请号：EP22785440.3

申请日：2022-04-07

申请人： North Carolina State University ,  Nirvana Sciences

发明人： LINDSEY, Jonathan S. ,  MACNEVIN, Christopher ,  AKHIGBE, Joshua ,  GORCZYNSKI, Michael ,  TANIGUCHI, Masahiko

IPC分类号： A61K49/00 ,  C07D487/22

公开(公告)号：EP4132939B1

公开(公告)日：2024-01-31

申请号：EP21715289.1

申请日：2021-04-01

发明人： STOESSEL, Philipp

IPC分类号： H10K85/30 ,  C07F5/02 ,  C07F7/08 ,  C07F9/6584 ,  C07D471/22 ,  C07D487/22 ,  C07D513/22 ,  C07F9/6564 ,  H10K85/60

公开(公告)号：EP3340983B1

公开(公告)日：2023-10-04

申请号：EP16840165.1

申请日：2016-08-25

发明人： WILES, Jason, Allan ,  PHADKE, Avinash, S. ,  DESHPANDE, Milind ,  AGARWAL, Atul ,  CHEN, Dawei ,  GADHACHANDA, Venkat, Rao ,  HASHIMOTO, Akihiro ,  PAIS, Godwin ,  WANG, Qiuping ,  WANG, Xiangzhu ,  GREENLEE, William

IPC分类号： C07D487/04 ,  C07D487/22 ,  C07D493/04 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07F9/6558 ,  C07D403/04 ,  C07D403/10 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  A61P29/00 ,  A61P37/00 ,  C07D403/14 ,  C07D407/14 ,  C07D409/14 ,  A61P1/16

公开(公告)号：EP4201937A1

公开(公告)日：2023-06-28

申请号：EP21857691.6

申请日：2021-08-18

申请人： Guangzhou EEC Biotech Development Co., Ltd.

发明人： ZHAO, Weijie ,  SU, Jiang'an ,  LI, Qing ,  WANG, Xiaohuai ,  SHAO, Kun ,  YU, Bo ,  WANG, Xiaqing

IPC分类号： C07D487/22 ,  A61K41/00 ,  A61P35/00 ,  A61P35/04

摘要： The present invention relates to a chlorin derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, an anti-tumor composition including the chlorin derivative or the pharmaceutically acceptable salt thereof, use of the chlorin derivative or the pharmaceutically acceptable salt thereof in the manufacture of an anti-tumor drug, and a combination of the chlorin derivative or the pharmaceutically acceptable salt thereof and an ultrasound medical system. The chlorin derivative or the pharmaceutically acceptable salt thereof has a structure represented by formula (I), and the ultrasonic medical system comprises a transducer ultrasonic bed and a contact agent. The chlorin derivative of the present invention can be used in photodynamic therapy and sonodynamic therapy, thereby effectively inhibiting and treating cancer.

公开(公告)号：EP4172252A1

公开(公告)日：2023-05-03

申请号：EP21734365.6

申请日：2021-06-29

申请人： Luxembourg Institute of Science and Technology (LIST)

发明人： BOSCHER, Nicolas ,  BABA, Kamal ,  BENGASI, Giuseppe ,  HUERTA FLORES, Ali, Margot

IPC分类号： C08J7/16 ,  C07D487/22 ,  C08G12/26

公开(公告)号：EP4157907A1

公开(公告)日：2023-04-05

申请号：EP21732586.9

申请日：2021-06-01

申请人： Bio-Fence Ltd.

发明人： HITRIK, Maria

IPC分类号： C08G12/32 ,  C08G12/38 ,  C08L61/28 ,  C08L61/30 ,  C09D161/28 ,  C09D161/30 ,  C07D251/64 ,  C07D487/22

公开(公告)号：EP4101506A1

公开(公告)日：2022-12-14

申请号：EP21750642.7

申请日：2021-02-04

申请人： The University of Tokyo ,  Savid Therapeutics Inc.

发明人： KANAI Motomu ,  YAMATSUGU Kenzo ,  TATSUMI Toshifumi ,  TAKAHASHI Kazuki ,  KODAMA Tatsuhiko ,  SUGIYAMA Akira ,  TSUKAGOSHI Masanobu ,  TODA Yuzo

IPC分类号： A61P35/00 ,  C09B47/30 ,  C07K16/28 ,  C07F7/10 ,  C07D487/22 ,  A61K47/55 ,  A61K47/64 ,  A61K47/68 ,  A61K41/00 ,  A61K31/695

摘要： Objects of the present invention are to provide a novel phthalocyanine dye for use in photoimmunotherapy, and a method for producing the same, and to provide a conjugate of the above-described phthalocyanine dye and an antibody or a peptide. According to the present invention, a compound represented by the following formula (1) or a salt thereof is provided:

wherein X represents a substituent having a hydrophilic group at the terminus thereof; L 3 , L 4 , L 5 , and L 6 each independently represent a divalent linking group; Y represents a group capable of binding to an antibody or a peptide; R 3 represents a substituent, such as an alkyl group containing 1 to 6 carbon atoms, an alkoxy group containing 1 to 6 carbon atoms, a halogen atom, -SR 11 , -SOR 12 , an aryl group containing 6 to 10 carbon atoms, -N(R 13 )(R 14 ), or -NO 2 , wherein when a plurality of R 3 s are present, the plurality of R 3 s may be identical to or different from one another; and s represents an integer of 0 to 4.

公开(公告)号：EP4032885A1

公开(公告)日：2022-07-27

申请号：EP22159533.3

申请日：2017-04-05

申请人： GlaxoSmithKline Intellectual Property Development Limited

发明人： CHARNLEY, Adam Kenneth ,  DARCY, Michael G. ,  DODSON, Jason W. ,  DONG, Xiaoyang ,  HUGHES, Terry V. ,  KANG, Jianxing ,  LEISTER, Lara Kathryn ,  LIAN, Yiqian ,  LI, Yue ,  MEHLMANN, John F. ,  NEVINS, Neysa ,  RAMANJULU, Joshi M. ,  ROMANO, Joseph J. ,  WANG, Gren Z. ,  YE, Guosen ,  ZHANG, Daohua

IPC分类号： C07D405/14 ,  C07D413/14 ,  C07D403/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/09 ,  A61K31/4184 ,  A61P31/08 ,  A61P35/00 ,  A61P37/00

摘要： Disclosed are compounds having the formula:

wherein q, r, s, A, B, C, R A1 , R A2 , R B1 , R B2 , R C1 , R C2 , R 3 , R 4 , R 5 , R 6 , R 14 , R 15 , R 16 , and R 17 , are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.