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    VEGF-REGULATING PEPTIDES
    7.
    发明公开
    VEGF-REGULATING PEPTIDES 审中-公开

    公开(公告)号：EP4023295A1

    公开(公告)日：2022-07-06

    申请号：EP20383169.8

    申请日：2020-12-29

    申请人： IDP Discovery Pharma, S.L.

    发明人： ESTEBAN MARTÍN, Santiago ,  NEVOLA, Laura ,  MORENO RAJA, Miguel Ramon ,  MONTENEGRO ARCE, María Fernanda ,  RODRÍGUEZ LÓPEZ, José Neptuno

    IPC分类号： A61P35/00 ,  C07K7/56 ,  C07K14/47

    摘要： The invention provides a peptide or a pharmaceutical salt thereof having a length from 14 to 50 and comprising a sequence having at least a 85% of sequence identity with respect to SEQ ID NO: 1, wherein "m", "n", "p", and "q" represent integers and are selected from 0 and 1; the C-terminal end corresponds to -C(O)R 4 ; and N-terminal end corresponds to -NHR 5 ; the peptide optionally comprising a linker biradical "L" of formula (I) connecting an alpha carbon atom of an amino acid located at position "i" with an alpha carbon atom of an amino acid located at position "i+4" or "i+7" in the peptide sequence SEQ ID NO: 1.
    The present invention also provides fusion proteins and pharmaceutical compositions comprising the peptides of the invention as well as their use in therapy and, particularly, in the treatment of a disease caused by an increase or reduction in VEGF levels.