-
公开(公告)号：EP3960754A3
公开(公告)日：2022-07-06
申请号：EP21180511.4
申请日：2015-05-15
发明人： BHANDARI, Ashok , PATEL, Dinesh V. , ZEMEDE, Genet , FREDERICK, Brian Troy , MATTHEAKIS, Larry C.
摘要： The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo.
-
公开(公告)号：EP2981543A1
公开(公告)日：2016-02-10
申请号：EP14780207.8
申请日：2014-03-31
摘要： The invention relates to disulfide-rich peptide molecules which inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, and show high selectivity against α4β1 binding.
-
公开(公告)号：EP3960754A2
公开(公告)日：2022-03-02
申请号：EP21180511.4
申请日：2015-05-15
发明人： BHANDARI, Ashok , PATEL, Dinesh V. , ZEMEDE, Genet , FREDERICK, Brian Troy , MATTHEAKIS, Larry C.
摘要： The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo.
-
-
5.发明公开NOVEL CYCLIC MONOMER AND DIMER PEPTIDES HAVING INTEGRIN ANTAGONIST ACTIVITY 审中-公开具有整合拮抗剂活性的新型环状单体和二聚体肽
公开(公告)号：EP3201217A1
公开(公告)日：2017-08-09
申请号：EP15846983.3
申请日：2015-10-01
发明人： BHANDARI, Ashok , PATEL, Dinesh V. , ZEMEDE, Genet
CPC分类号： C07K14/70546 , A61K38/00 , A61K47/542 , A61K47/545 , A61K47/60 , A61P1/00 , A61P29/00 , A61P37/00 , C07K7/06 , C07K7/08 , C07K14/7055
摘要： The invention relates to C to N cyclized (C-N cyclic) monomer and dimer peptide molecules, as well as peptide dimers which are connected by linker moieties at the N terminus and the C terminus of each peptide subunit, which inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, and show high selectivity against α4β1 binding.
摘要翻译： 本发明涉及C至N环化（CN环状）单体和二聚体肽分子以及肽二聚体，其通过每个肽亚基的N末端和C末端处的接头部分连接，其抑制α4β7与粘膜的结合 addressin细胞粘附分子（MAdCAM）在体内，并显示出针对α4β1结合的高选择性。
-
公开(公告)号：EP2906584A1
公开(公告)日：2015-08-19
申请号：EP13845982.1
申请日：2013-10-11
摘要： The invention relates to disulfide-rich dimer molecules which inhibit binding of α4&bgr;7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, and show high selectivity against α4&bgr;1 binding.
摘要翻译： 本发明涉及抑制α4β7与粘膜地址素细胞粘附分子（MAdCAM）在体内结合的二硫键丰富的二聚体分子，并显示出对抗α4β1结合的高选择性。
-
7.发明公开
公开(公告)号：EP4378536A2
公开(公告)日：2024-06-05
申请号：EP24156804.7
申请日：2015-07-15
发明人： BOURNE, Gregory , BHANDARI, Ashok , CHENG, XiaoLi , FREDERICK, Brian Troy , ZHANG, Jie , PATEL, Dinesh V. , LIU, David
IPC分类号： A61P43/00
CPC分类号： G01N2800/06520130101 , C07K14/54 , A61K38/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P11/00 , A61P11/02 , A61P11/06 , A61P15/14 , A61P17/06 , A61P19/02 , A61P35/00 , A61P37/06 , A61P43/00 , A61P5/48 , A61P3/10
摘要： The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease.
-
公开(公告)号：EP2906584B1
公开(公告)日：2019-11-20
申请号：EP13845982.1
申请日：2013-10-11
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705
-
公开(公告)号：EP2981544B1
公开(公告)日：2019-09-04
申请号：EP14779463.0
申请日：2014-03-31
-
公开(公告)号：EP3432906A1
公开(公告)日：2019-01-30
申请号：EP17771175.1
申请日：2017-03-23
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.017 秒)
