公开(公告)号：EP4441069A1

公开(公告)日：2024-10-09

申请号：EP22844394.1

申请日：2022-12-02

Applicant: Bristol-Myers Squibb Company

Inventor： QIAO, Jennifer X. ,  POSS, Michael A. ,  ALLEN, Martin, Patrick ,  MAPELLI, Claudio ,  QUESNELLE, Claude, A. ,  TORTOLANI, David, R. ,  WANG, Tammy, C. ,  WANG, Tao ,  ZHANG, Yong ,  ZHANG, Yunhui ,  ZHANG, Zhongxing

IPC: C07K7/56 ,  A61P35/00 ,  A61P31/00 ,  A61P37/04 ,  C07D513/14 ,  A61K38/00 ,  A61K39/00

CPC classification number: C07K7/56 ,  A61P35/00 ,  A61K38/00 ,  A61P31/00 ,  A61P37/04

公开(公告)号：EP1928879B1

公开(公告)日：2013-02-13

申请号：EP06825074.5

申请日：2006-09-22

Applicant: Bristol-Myers Squibb Company

Inventor： VACCARO, Wayne ,  CHEN, Zhong ,  DODD, Dharmpal, S. ,  HUYNH, Tram, N. ,  LIN, James ,  LIU, Chunjian ,  MUSSARI, Christopher, P. ,  TOKARSKI, John, S. ,  TORTOLANI, David, R. ,  WROBLESKI, Stephen, T.

IPC: C07D487/04 ,  A61K31/437 ,  A61P29/00

CPC classification number: C07D487/04

公开(公告)号：EP1146871A1

公开(公告)日：2001-10-24

申请号：EP99968927.6

申请日：1999-12-21

Applicant: Bristol-Myers Squibb Company

Inventor： POSS, Michael, A. ,  TORTOLANI, David, R. ,  MATTSON, Ronald, J. ,  YEVICH, Joseph, P.

IPC: A61K31/385 ,  A61K31/445 ,  A61K31/47 ,  A61K31/495 ,  A61K31/4995 ,  A61K31/50 ,  A61K31/55 ,  C07D215/12 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14

CPC classification number: C07D401/14 ,  C07D211/20 ,  C07D211/34 ,  C07D405/14 ,  C07D417/14

Abstract: Compounds of formula (I) are useful antidepressant agents demonstrating potent inhibition of 5-HT reuptake. Z is selected from among various phenyl and hetaryl moieties while Y is benzyl or indolyl.

公开(公告)号：EP1928879A2

公开(公告)日：2008-06-11

申请号：EP06825074.5

申请日：2006-09-22

Applicant: Bristol-Myers Squibb Company

Inventor： VACCARO, Wayne ,  CHEN, Zhong ,  DODD, Dharmpal, S. ,  HUYNH, Tram, N. ,  LIN, James ,  LIU, Chunjian ,  MUSSARI, Christopher, P. ,  TOKARSKI, John, S. ,  TORTOLANI, David, R. ,  WROBLESKI, Stephen, T.

IPC: C07D487/04 ,  A61K31/437 ,  A61P29/00

CPC classification number: C07D487/04

Abstract: Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, and hydrates, thereof, (I) are useful as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, and Z is N or CR3, and R1, R2, R3, X and Y are as defined herein.

公开(公告)号：EP1534273A2

公开(公告)日：2005-06-01

申请号：EP03765638.6

申请日：2003-07-17

Applicant: Bristol-Myers Squibb Company

Inventor： VACCARO, Wayne ,  YANG, Bingwei, Vera ,  KIM, Soong-Hoon ,  HUYNH, Tram ,  TORTOLANI, David, R. ,  LEAVITT, Kenneth, J. ,  LI, Wenying ,  DOWEYKO, Arthur, M. ,  CHEN, Xiao-Tao ,  DOWEYKO, Lidia

IPC: A61K31/415 ,  A61K31/425 ,  A61K31/495 ,  A61K31/50

CPC classification number: C07D495/04 ,  A61K31/403 ,  A61K31/473 ,  A61K45/06 ,  C07D207/34 ,  C07D209/48 ,  C07D213/40 ,  C07D213/75 ,  C07D213/82 ,  C07D215/38 ,  C07D217/22 ,  C07D231/16 ,  C07D233/88 ,  C07D235/14 ,  C07D235/30 ,  C07D239/42 ,  C07D239/94 ,  C07D241/20 ,  C07D261/12 ,  C07D261/14 ,  C07D263/48 ,  C07D277/46 ,  C07D277/64 ,  C07D285/06 ,  C07D307/58 ,  C07D317/58 ,  C07D333/20 ,  C07D333/34 ,  C07D401/04 ,  C07D405/04 ,  C07D417/04 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  A61K2300/00

Abstract: Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure formula (I), where Z is CONR1R2 or CH2NR1R2 and where R, Ra, Rb, Rc, Rd, Z, A and B are defined herein.