公开(公告)号：EP2261354A3

公开(公告)日：2012-01-11

申请号：EP10178543.4

申请日：1999-04-30

申请人： Novartis Vaccines and Diagnostics, Inc. ,  J. Craig Venter Institute, Inc.

发明人： Fraser, Claire ,  Galeotti, Cesira ,  Grandi, Guido ,  Hickey, Erin ,  Masignani, Vega ,  Mora, Marirosa ,  Petersen, Jeremy ,  Pizza, Mariagrazia ,  Rappuoli, Rino ,  Ratti, Giulio ,  Scarlato, Vincenzo ,  Scarselli, Maria ,  Tettelin, Hervé ,  Venter, J. Craig

IPC分类号： C12N15/31 ,  C07K14/22 ,  C07K16/12 ,  C12Q1/68 ,  A61K39/095 ,  G01N33/50

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K39/095 ,  A61K2039/55505 ,  Y10S530/806 ,  Y10S530/825

摘要： The invention provides proteins from Neisseria mcningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

公开(公告)号：EP2261356A3

公开(公告)日：2012-01-04

申请号：EP10179068.1

申请日：1999-04-30

申请人： Novartis Vaccines and Diagnostics, Inc. ,  J. Craig Venter Institute, Inc.

发明人： Fraser, Claire ,  Galeotti, Cesira ,  Grandi, Guido ,  Hickey, Erin ,  Masignani, Vega ,  Mora, Marirosa ,  Petersen, Jeremy ,  Pizza, Mariagrazia ,  Rappuoli, Rino ,  Ratti, Giulio ,  Scarlato, Vincenzo ,  Scarselli, Maria ,  Tettelin, Hervé ,  Venter, J. Craig

IPC分类号： C12N15/31 ,  C07K14/22 ,  C07K16/12 ,  C12Q1/68 ,  A61K39/095 ,  G01N33/50

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K39/095 ,  A61K2039/55505 ,  Y10S530/806 ,  Y10S530/825

摘要： The invention provides proteins from Neisseria mcningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

公开(公告)号：EP2261344A3

公开(公告)日：2012-01-04

申请号：EP10178521.0

申请日：1999-04-30

申请人： Novartis Vaccines and Diagnostics, Inc. ,  J. Craig Venter Institute, Inc.

发明人： Fraser, Claire ,  Galeotti, Cesira ,  Grandi, Guido ,  Hickey, Erin ,  Masignani, Vega ,  Mora, Marirosa ,  Petersen, Jeremy ,  Pizza, Mariagrazia ,  Rappuoli, Rino ,  Ratti, Giulio ,  Scarlato, Vincenzo ,  Scarselli, Maria ,  Tettelin, Hervé ,  Venter, J. Craig

IPC分类号： C12N15/31 ,  C07K14/22 ,  C07K16/12 ,  C12Q1/68 ,  A61K39/095 ,  G01N33/50

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K39/095 ,  A61K2039/55505 ,  Y10S530/806 ,  Y10S530/825

摘要： The invention provides proteins from Neisseria mcningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

公开(公告)号：EP2281832A3

公开(公告)日：2011-12-14

申请号：EP10173861.5

申请日：2001-07-05

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Zur Megede, Jan ,  Barnett, Susan W.

IPC分类号： C07K14/16 ,  A61K39/21 ,  C12N5/10

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/53 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immumization, generation of packaging cell lines, and production of HIV Tyre C proteins are also described.

摘要翻译： 本发明涉及编码免疫原性HIV C型多肽的多核苷酸。 还描述了多核苷酸在包括DNA免疫，包装细胞系的产生和HIV轮胎C蛋白质产生的应用中的用途。

公开(公告)号：EP1845990B1

公开(公告)日：2011-09-28

申请号：EP06733986.1

申请日：2006-01-27

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： LOPES DE MENEZES, Daniel, c/o Chiron Corporation ,  HEISE, Carla, c/o Chiron Corporation ,  XIN, Xiaohua, c/o Chiron Corporation

IPC分类号： A61K31/497 ,  A61P35/00

CPC分类号： A61K31/496 ,  A61K31/497

摘要： Methods of treating metastatic cancer such as metastasized tumors include administering a compound of Structure I, a tautomer of the compound, a pharmaceutically acceptable salt of the compound, a pharmaceutically acceptable salt or the tautomer, or a mixture thereof to a subject. The compound, tautomer, salt of the compound, salt of the tautomer, or mixture thereof may be used to prepare medicaments for treating metastatic cancer. The variable A has the values defined herein.

公开(公告)号：EP1844815B1

公开(公告)日：2011-09-14

申请号：EP07075155.7

申请日：2004-11-04

申请人： Novartis Vaccines and Diagnostics, Inc. ,  XOMA Technology Ltd.

发明人： Long, Li, ,  Luqman, Mohammad ,  Yabannavar, Asha ,  Zaror, Isabel

IPC分类号： A61P35/02 ,  A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2878 ,  A61K2039/507 ,  C07K16/2887 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： Methods of treating a human subject for a cancer characterized by neoplastic B cell growth are provided. The methods comprise administering combination antibody therapy to the subject, where an effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof in combination with an anti-CD20 antibody or antigen-binding fragment thereof is administered to the subject. The invention further comprises pharmaceutical compositions with combinations of these antibodies in a pharmaceutically acceptable carrier.

公开(公告)号：EP2266602A3

公开(公告)日：2011-08-10

申请号：EP10178110.2

申请日：2005-11-01

申请人： Novartis Vaccines and Diagnostics, Inc. ,  The Government of the U.S.A. as represented by The Secretary of the dept. of Health & Human Services

发明人： Barnett, Susan W. ,  Gomez-Roman, Victor Raul ,  Robert-Guroff, Marjorie ,  Srivastava, Indresh K.

IPC分类号： A61K39/21 ,  C07K14/16

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2760/16134

摘要： The present invention relates to methods, polypeptides, and polynucleotides encoding immunogenic identical or analogous HIV polypeptides derived from the same or different strains within an HIV subtype and/or different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are also described. The combination approaches described herein induce broad and potent immune responses against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.

公开(公告)号：EP2336368A1

公开(公告)日：2011-06-22

申请号：EP10176402.5

申请日：2001-12-07

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Garcia, Pablo ,  Hardy, Stephen F. ,  Williams, Lewis T. ,  Escobedo, Jaime

IPC分类号： C12Q1/70 ,  G01N33/574 ,  C07K14/15 ,  A61K48/00 ,  A61P35/00 ,  C12Q1/68 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C12N7/00 ,  C12N2740/10021 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q1/702 ,  C12Q2600/158 ,  G01N33/57434 ,  G01N2333/15

摘要： Human endogenous retroviruses of the HML-2 family show up-regulated expression in prostate tumors. This finding can be used in prostate cancer screening, diagnosis and therapy.

摘要翻译： HML-2家族的人内源性逆转录病毒在前列腺肿瘤中显示出上调的表达。 这一发现可用于前列腺癌筛查，诊断和治疗。

公开(公告)号：EP2332573A1

公开(公告)日：2011-06-15

申请号：EP10179805.6

申请日：2002-04-11

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Polo, John ,  Perri, Sylvia ,  Thudium, Kent

IPC分类号： A61K39/12 ,  A61K39/21 ,  A61K39/295 ,  C12N15/79 ,  C12N15/86 ,  C12N15/87

CPC分类号： C07K14/005 ,  C12N15/86 ,  C12N2770/36122 ,  C12N2770/36143 ,  C12N2770/36145 ,  C12N2810/10

摘要： Chimeric alphaviruses and alphavirus replicon particles are provided including methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules derived from one or more alphaviruses and structural proteins (capsid and/or envelope) from at least two or more alphaviruses. Methods of making, using, and therapeutic preparations containing the chimeric alphavirus particle, are disclosed.

摘要翻译： 提供嵌合甲病毒和甲病毒复制子颗粒，包括制备和使用它们的方法。 具体地，提供了甲型病毒颗粒，其具有衍生自至少两种或更多种甲病毒属的一种或多种甲病毒和结构蛋白（衣壳和/或包膜）的核酸分子。 公开了制备，使用和含有嵌合甲病毒颗粒的治疗制剂的方法。

公开(公告)号：EP2283897A3

公开(公告)日：2011-06-15

申请号：EP10180658.6

申请日：2001-10-26

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Shirley, Bret ,  Choe, Minna ,  Tellers, Melanie ,  Babuka, Susan

IPC分类号： A61P25/00 ,  A61K38/21 ,  A61K47/18

CPC分类号： A61K9/0019 ,  A61K38/1816 ,  A61K38/215 ,  A61K47/12 ,  A61K47/183

摘要： Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.