公开(公告)号：EP3450439A1

公开(公告)日：2019-03-06

申请号：EP17789327.8

申请日：2017-04-17

申请人： Sumitomo Chemical Co., Ltd.

发明人： SATO, Kanako ,  IHARA, Hideki

IPC分类号： C07F9/572

摘要： A compound represented by formula (3):

or an enantiomer thereof, which is a monomer that can be used for the production of a single-stranded nucleic acid molecule capable of suppressing the expression of a target gene, can be obtained by:
reacting a compound represented by formula (1):

or an enantiomer thereof with 6-hydroxyhexanoic acid in a solvent in the presence of an additive such as 1-hydroxybenzotriazole and a condensing agent, and then mixing the resultant reaction mixture, water, and a base such as alkali metal hydroxide to produce a compound represented by formula (2) :

or an enantiomer thereof; and
reacting the compound represented by formula (2) or an enantiomer thereof with 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite in a solvent in the presence of a coupling activator such as a diisopropylaminetetrazole salt.

公开(公告)号：EP3437641A1

公开(公告)日：2019-02-06

申请号：EP17774997.5

申请日：2017-03-28

申请人： Daiichi Sankyo Company, Limited

发明人： NOGUCHI, Kengo ,  ITO, Yusuke

IPC分类号： A61K31/4172 ,  A61P1/04

摘要： A therapeutic agent for inflammatory bowel diseases comprising as an active ingredient a compound represented by the formula (I) wherein R represents a hydrogen atom or a [1-(isobutyryloxy)ethoxy]carbonyl group or the like, or a pharmacologically acceptable salt thereof.

公开(公告)号：EP3323808A1

公开(公告)日：2018-05-23

申请号：EP16814478.0

申请日：2016-06-24

申请人： Daiichi Sankyo Co., Ltd.

发明人： UEDA, Tsuyoshi ,  ABE, Yuzo

IPC分类号： C07D233/64 ,  C07C68/06 ,  C07C69/96 ,  C12P41/00 ,  C07B61/00

CPC分类号： C07D233/64 ,  C07B43/06 ,  C07B61/00 ,  C07B2200/13 ,  C07C68/06 ,  C07C69/96 ,  C12P17/14 ,  C12P41/00 ,  C12Y301/01003

摘要： A method for producing a 1-(acyloxy)alkyl carbamate derivative (III), using a fluorous alkyl carbonate derivative (I), and a fluorous alkyl carbonate derivative (I) and a method for producing the same. In the formula, R 1 represents C 1 -C 4 alkyl group or a C 3 -C 6 cycloalkyl group, R 2 represents a C 1 -C 4 alkyl group or a hydrogen atom, and A represents a fluorous alkyl group (wherein the fluorous alkyl group represents a C 2 -C 11 alkyl group in which 40% or more of the hydrogen atoms are replaced by fluorine atoms).

公开(公告)号：EP2983510B1

公开(公告)日：2018-05-09

申请号：EP14712027.3

申请日：2014-03-14

申请人： Tate & Lyle Ingredients Americas LLC ,  Tate & Lyle Technology Limited

发明人： WOODYER, Ryan D. ,  COHEN, Jason C. ,  BRIDGES, John R.

IPC分类号： A23L27/30 ,  A23L2/52 ,  A23L2/60

CPC分类号： A23L27/33 ,  A23L2/60 ,  A23L5/00 ,  A23L27/37 ,  A23L29/30 ,  A23L33/125 ,  A23P20/10 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/16 ,  A61K8/60 ,  A61K47/26 ,  A61K2800/5922 ,  A61Q11/00 ,  A23V2200/132 ,  A23V2200/14 ,  A23V2200/15 ,  A23V2250/264 ,  A23V2250/60 ,  A23V2250/606

摘要： A low calorie sweetener composition with sweetness synergy, providing a reduction in off-taste and a desirable temporal profile. The sweetener composition is suitable for use as a substitute for high calorie sugars. The sweetener composition may be used in food and beverage products, pharmaceutical products, nutritional product and cosmetic products.

公开(公告)号：EP2681187B1

公开(公告)日：2018-04-11

申请号：EP12752878.4

申请日：2012-02-27

申请人： Scinopharm Taiwan Ltd.

发明人： LIAO, JyhHsiung ,  KUO, LungHuang

IPC分类号： C07C213/08 ,  C07C229/22 ,  C07C269/06 ,  C07C271/16 ,  C07C271/18 ,  C07C317/28 ,  C07C323/43 ,  C07D207/08

CPC分类号： C07C229/22 ,  C07C213/08 ,  C07C269/06 ,  C07C271/16 ,  C07C271/18 ,  C07C317/28 ,  C07C323/43 ,  C07D207/08 ,  C07C219/22

摘要： The present invention provides an efficient and scalable process to prepare the compound of formula 4 by reduction of the corresponding α-acyloxy sulfides.

公开(公告)号：EP2904017B1

公开(公告)日：2018-02-14

申请号：EP13771582.7

申请日：2013-10-02

申请人： Tate & Lyle Ingredients Americas LLC

发明人： SANTHANAM, Balaji ,  HUTTON, Thomas K

IPC分类号： C08B30/12 ,  C08B30/14 ,  C09J103/02 ,  C08L3/02

CPC分类号： C08B30/12 ,  A23L5/25 ,  A23L5/49 ,  A23L29/212 ,  A23L29/219 ,  A23L29/35 ,  A23V2002/00 ,  C08B30/04 ,  C08B30/14 ,  C08B30/18 ,  C08B31/003 ,  C08L3/04

摘要： The present invention provides a process for preparing an inhibited starch comprising, in order: a) extracting starch from a native source and partially refining to provide a partially refined starch having a residual protein content on a dry starch basis of more than 0.4% by weight and less than 8.0% by weight; b) treating said partially refined starch with a bleaching agent to provide an inhibited starch; and c) recovering said inhibited starch.

公开(公告)号：EP2608851B1

公开(公告)日：2017-12-20

申请号：EP11820237.3

申请日：2011-08-26

申请人： Les Mills International Limited

发明人： LOVERGROVE, David Neil ,  BEST, Darryl John ,  DAVIES, William ,  LOW, Tyrone David

IPC分类号： A63B21/075 ,  A63B21/06

CPC分类号： A63B21/0728 ,  A63B21/0004 ,  A63B21/00065 ,  A63B21/0722 ,  A63B21/0724 ,  A63B21/0726 ,  A63B21/075 ,  A63B23/12 ,  A63B23/1281

摘要： Exercise equipment comprising a grippable handle at which said exercise equipment can be lifted by a user, and at least one docking assembly connected to the grippable handle. The docking assembly has opposing arms that define a slot in which at least one weight plate can be removably mounted. At least one locking member is located on the docking assembly to capture and/or lock at one weight plate to the docking assembly once received in the slot.

公开(公告)号：EP2732906B1

公开(公告)日：2017-11-08

申请号：EP12811007.9

申请日：2012-07-06

申请人： Daiichi Kigenso Kagaku Kogyo Co., Ltd.

发明人： NAGAE, Takahiro

IPC分类号： B23K35/363 ,  B23K35/362 ,  B23K35/36 ,  B23K35/28 ,  B23K103/10

CPC分类号： B23K35/3605 ,  B23K35/286 ,  B23K35/362 ,  B23K2203/10

公开(公告)号：EP3210982A1

公开(公告)日：2017-08-30

申请号：EP17155905.7

申请日：2009-12-07

申请人： Gilead Sciences, Inc.

发明人： DESAI, Manoj C. ,  HALCOMB, Randall L. ,  HRVATIN, Paul ,  HUI, Hon Chung ,  McFADDEN, Ryan ,  ROETHLE, Paul A. ,  YANG, Hong

IPC分类号： C07D403/12

CPC分类号： A61K31/519 ,  A61K31/527 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/573 ,  A61K31/683 ,  A61K31/7056 ,  A61K31/7072 ,  A61K31/708 ,  A61K38/16 ,  A61K38/21 ,  A61K38/212 ,  A61K45/06 ,  C07D403/12 ,  C07D475/06 ,  C07D475/08 ,  C07D475/10 ,  C07D475/12 ,  C07D487/04 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/391 ,  Y02A50/393 ,  Y02A50/395

摘要： Provided are compounds of Formula Ia:

pharmaceutically acceptable salts thereof, compositions containing such compounds, and such compounds for use in the treatment of a hepatitis B viral infection.

摘要翻译： 提供了式Ia化合物：其药学上可接受的盐，含有这些化合物的组合物以及用于治疗乙型肝炎病毒感染的此类化合物。

公开(公告)号：EP3160261A1

公开(公告)日：2017-05-03

申请号：EP15736751.7

申请日：2015-06-29

申请人： Tate & Lyle Ingredients Americas LLC

发明人： ARMENTROUT, Richard W. ,  MATTHEW, Susan ,  FLETCHER, Josh ,  MEDHEKAR, Rohit

IPC分类号： A23L5/00

CPC分类号： A23L7/122 ,  A23L5/00 ,  A23L7/00 ,  A23L21/00 ,  A23L29/30 ,  A23L33/125 ,  A23P20/10 ,  A23P20/18 ,  A23V2002/00

摘要： Opaque coatings are formed on consumable articles by applying an aqueous composition of one or more trisaccharides such as melezitose (optionally, in combination with one or more other ingredients such as a high intensity sweetener) and then drying the applied aqueous composition. “Frosted” coatings having a reduced sugar (sucrose) content may thereby be obtained.

摘要翻译： 通过施用一种或多种三糖如松三糖（任选地，与一种或多种其它成分如高强度甜味剂组合）的含水组合物并随后干燥所施用的含水组合物，在消费品上形成不透明涂层。 由此可以获得具有降低的糖（蔗糖）含量的“磨砂”涂层。