公开(公告)号：EP4306572A1

公开(公告)日：2024-01-17

申请号：EP22767063.5

申请日：2022-03-07

申请人： AGC INC. ,  The University of Tokyo ,  National University Corporation Tokyo Medical and Dental University

发明人： HARA, Mihoko ,  HARA, Rintaro ,  MIYATA, Kanjiro ,  NAITO, Mitsuru ,  YOKOTA, Takanori

IPC分类号： C08G69/48 ,  A61K31/7088 ,  A61K45/00 ,  A61K47/34 ,  A61K47/42 ,  A61K47/59 ,  A61K47/60 ,  A61K47/64 ,  A61K48/00 ,  A61P43/00

摘要： The present invention provides a polymer represented by the following formula (I):

wherein each symbol is as described in the specification, which is useful as a drug carrier in effectively delivering a drug to a target site.

公开(公告)号：EP4292599A1

公开(公告)日：2023-12-20

申请号：EP21930411.0

申请日：2021-12-21

申请人： FUJIFILM Corporation ,  National University Corporation Tokyo Medical and Dental University

发明人： NAKAMURA, Kentaro ,  TOMINAGA, Shunsuke ,  SEKIYA, Ichiro ,  MIZUNO, Mitsuru ,  KATANO, Hisako ,  OZEKI, Nobutake

IPC分类号： A61K35/28 ,  A61K35/32 ,  A61P19/02 ,  C12Q1/06 ,  G01N33/48

摘要： There are provided a production method for a therapeutic agent for arthrosis, in which a population including a plurality of mesenchymal stem cells being cultured is imaged to acquire a cell image, the cell image is analyzed to derive density information on the mesenchymal stem cells in the cell image, colonies, which are formed by the mesenchymal stem cells in the population, are detected based on the density information, and the population is sorted based on at least one of an average colony size or a colony forming unit, which is derived from the detected colonies, and provided a therapeutic agent for arthrosis, which is produced by the production method for a therapeutic agent for arthrosis.

公开(公告)号：EP4223871A1

公开(公告)日：2023-08-09

申请号：EP21875635.1

申请日：2021-09-28

申请人： National University Corporation Tokyo Medical and Dental University ,  Takeda Pharmaceutical Company Limited

发明人： TAKEBE Takanori ,  SAIKI Norikazu

IPC分类号： C12N5/077 ,  A61K35/55 ,  A61L27/36 ,  A61P5/18 ,  C12M1/00 ,  G01N33/15 ,  G01N33/50

摘要： The present invention provides means for producing a parathyroid gland organoid. A culture method of the present invention includes a cell population containing a parathyroid gland cell in a ratio of 50% or more, and a mesenchymal cell in a ratio of 10% or more; and a step of culturing the cell population.

公开(公告)号：EP4177341A1

公开(公告)日：2023-05-10

申请号：EP21832413.5

申请日：2021-07-02

申请人： FUJIFILM Corporation ,  National University Corporation Tokyo Medical and Dental University

发明人： SEKIYA, Ichiro ,  MIZUNO, Mitsuru ,  KATANO, Hisako ,  OZEKI, Nobutake ,  NAKAMURA, Kentaro ,  YOSHIDA, Tomomi

IPC分类号： C12N5/0775 ,  A61K35/32 ,  A61P19/02

摘要： An object of the present invention is to provide a production method for a synovium-derived mesenchymal stem cell, which makes it possible to obtain a sufficient amount of synovium-derived mesenchymal stem cells from the synovial tissue, a production method for a cell preparation for joint medical treatment using the production method for a synovium-derived mesenchymal stem cell, synovium-derived mesenchymal stem cell, and a cell preparation for a joint medical treatment. According to the present invention, there is provided a production method for a synovium-derived mesenchymal stem cell, which includes treating a synovial tissue with an enzyme for 2 hours or more; and washing a mixture after the enzyme treatment until a residual enzyme concentration in a supernatant is 0.5 ng/mL or less, to obtain a synovium-derived mesenchymal stem cell.

公开(公告)号：EP4137795A1

公开(公告)日：2023-02-22

申请号：EP22190967.4

申请日：2022-08-18

申请人： National University Corporation Tokyo Medical and Dental University ,  Kyoto Prefectural Public University Corporation ,  SYSMEX CORPORATION

发明人： Inazawa, Johji ,  Kuroda, Junya ,  Kinoshita, Masaki

IPC分类号： G01N15/14 ,  G01N21/64 ,  G06T7/00 ,  G01N15/10

摘要： A fluorescence image analyzer 10 has an imaging unit 154 for capturing a first image containing at least a part of a region of a cell as an imaging target for a plurality of cells in a sample in which a target site on a chromosome is labeled with a fluorescent dye, and a second image including fluorescence generated from a fluorescent dye labeling the target site of the cell of the first image. The processing unit 11 of the fluorescence image analyzer 10 selects a plurality of test cells having specific morphological characteristics to be tested from a plurality of cells based on at least the first image, and extracts the bright spots of fluorescence generated from the fluorescent dye from at least a plurality of test cells. The processing unit 11 identifies cells with chromosomal abnormalities and/or cells without chromosomal abnormalities based on the extracted bright spots, and generates information related to the ratio of cells with chromosomal abnormalities relative to the test cells based on the number of cells with chromosomal abnormalities and/or the number of cells without chromosomal abnormalities.

公开(公告)号：EP4052726A1

公开(公告)日：2022-09-07

申请号：EP20882661.0

申请日：2020-10-29

申请人： National University Corporation Kumamoto University ,  National University Corporation Tokyo Medical and Dental University ,  JAPAN as represented by DIRECTOR GENERAL of National Institute of Infectious Diseases

发明人： MATSUSHITA Shuzo ,  YOSHIMURA Kazuhisa ,  TAMAMURA Hirokazu ,  MASUDA Ami ,  TAKAHASHI Kohei ,  KOBAYAKAWA Takuya ,  HARADA Shigeyoshi ,  MIURA Tomoyuki

IPC分类号： A61K39/395 ,  A61P31/18 ,  A61P43/00 ,  C07D221/20 ,  A61K31/4468

摘要： Provided is a CD4 mimic compound having an improved efficacy for anti-HIV treatment and a more improved pharmacokinetics.
There is provided a compound represented by the following formula (I):

wherein R 1 represents C 2 H 4 (OC 2 H 4 ) n -OCH 3 or C m H 2m+1 ; R 2 represents O or NH; n is 3 to 25; and m is 4 to 22,
or a salt thereof, and an HIV infection inhibitor comprising the compound or a salt thereof as an active ingredient.

公开(公告)号：EP4032551A1

公开(公告)日：2022-07-27

申请号：EP20864622.4

申请日：2020-09-16

申请人： National University Corporation Tokyo Medical and Dental University ,  Takeda Pharmaceutical Company Limited

发明人： YOKOTA, Takanori ,  NAGATA, Tetsuya ,  FURUKAWA, Hideki ,  YOGO, Takatoshi ,  NAKAGAWA, Yasuo ,  SASAKI, Shigekazu ,  TOKUNOH, Ryosuke ,  SEKI, Tomohiro ,  HIDAKA, Kosuke ,  KIKUCHI, Fumiaki ,  KUBO, Osamu ,  KASAHARA, Takahito ,  KOJIMA, Takuto ,  WANG, Junsi ,  TOKUNAGA, Norihito

IPC分类号： A61K48/00 ,  A61P25/00 ,  A61P43/00 ,  C12N5/079 ,  C12N5/10 ,  A61K47/54 ,  C12N15/113 ,  A61K31/713

摘要： The object of the present invention is to provide a nucleic acid agent that is efficiently delivered to the nervous system, for example, the central nervous system to which drug delivery can be prevented by BBB, and produces an antisense effect on the target transcriptional product at the delivery site, and a composition comprising the same. In an embodiment, the present invention provides a double-stranded nucleic acid complex formed by annealing a first nucleic acid strand that hybridizes to a part of a target transcriptional product and has an antisense effect on the target transcriptional product, and a second nucleic acid strand that comprises a base sequence complementary to the first nucleic acid strand and is bound to a C 22-35 alkyl group optionally substituted with a hydroxy group or an analog thereof.

公开(公告)号：EP3932934A1

公开(公告)日：2022-01-05

申请号：EP20763771.1

申请日：2020-02-26

申请人： National University Corporation Tokyo Medical and Dental University

发明人： TERADA, Sumio ,  SATO, Keisuke ,  NAKAI, Nori ,  SAITO, Kenta ,  KAWAGISHI, Masahiko

IPC分类号： C07K1/13 ,  C07K14/435 ,  C07K14/81 ,  C07K16/00 ,  C07K19/00 ,  G01N21/64 ,  C12N5/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/62 ,  C12N9/14 ,  G01N33/483 ,  G01N33/68

摘要： The present invention provides a fusion protein of an antigen-binding protein and a fluorescent protein or a fluorescence-labeled tag protein. The present invention provides a fusion protein of an antigen-binding protein and a fluorescent protein or a fluorescence-labeled tag, wherein the antigen-binding protein is an antigen-binding protein having a helix structure or a β-sheet structure at a terminus, the fluorescent protein or the fluorescence-labeled tag is a fluorescent protein or a fluorescence-labeled tag having a helix structure or a β-sheet structure at a terminus, and the helix at the terminus and the helix at the terminus are linked, or the β-sheet structure at the terminus and the β-sheet structure at the terminus are linked.

公开(公告)号：EP3804762A1

公开(公告)日：2021-04-14

申请号：EP19810343.4

申请日：2019-05-31

申请人： National University Corporation Tokai National Higher Education and Research System ,  National University Corporation Tokyo Medical and Dental University

发明人： SUGANAMI Takayoshi ,  TANAKA Miyako ,  MATSUMOTO Akira ,  MATSUMOTO hiroko ,  MOROOKA Yuki ,  MIYAHARA Yuji

IPC分类号： A61K47/32 ,  A61K9/00 ,  A61K38/28 ,  A61K47/18 ,  A61K47/24 ,  A61P3/10

摘要： The present invention provides a sugar-responsive gel that is highly resistant to temperature changes, and a sugar-responsive drug delivery device including such a gel. The sugar-responsive gel, which comprises a gel composition including a monomer having a hydroxyl group in addition to a phenylboronic-acid-based monomer, can exhibit suitable temperature resistance. A sugar-responsive drug delivery device including such a sugar-responsive gel is less susceptible to the effects of temperature changes, and therefore can prevent undesirable excessive delivery of a drug (such as insulin).

公开(公告)号：EP3712613A1

公开(公告)日：2020-09-23

申请号：EP18880950.3

申请日：2018-11-22

申请人： National University Corporation Tokyo Medical and Dental University

发明人： MITSUBAYASHI, Kohji ,  ARAKAWA, Takahiro ,  TOMA, Koji ,  SUZUKI, Takuma ,  IITANI, Kenta

IPC分类号： G01N33/497 ,  G01N1/02 ,  G01N21/05 ,  G01N21/64 ,  G01N21/78 ,  G01N33/50 ,  C12M1/34 ,  C12N11/08

摘要： There is provided a biological gas measurement device that continuously collects biological gas, and is able to immediately and chronologically measure a target substance from the collected biological gas. A skin gas measurement device includes a biological gas collector 10 having an aperture portion 11 in a side thereof that faces a living body, and having a recessed portion 12 that is connected with the aperture portion 11 and serves as a space for collecting biological gas, a measurement device 100 that measures a target substance in the biological gas collected by the biological gas collector 10, an outflow path 40 through which collected biological gas is discharged from the recessed portion 12 to the measurement device 100, and a correction device 124 that corrects measurements of the target substance performed by the measurement device 100, and enables measurement results of the target substance from which effects of moisture present inside the outflow path 40 have been excluded to be output.