公开(公告)号：EP2066676A1

公开(公告)日：2009-06-10

申请号：EP07838434.4

申请日：2007-09-18

申请人： Vertex Pharmaceuticals, Inc.

发明人： ARONOV, Alexander ,  COME, Jon ,  COURT, John ,  DEININGER, David ,  LAUFFER, David ,  LI, Pan ,  MCGINTY, Kira ,  NANTHAKUMAR, Suganthini ,  STAMOS, Dean ,  TANNER, Kirk

IPC分类号： C07D497/04 ,  C07D513/04 ,  A61K31/433 ,  A61P35/00

CPC分类号： C07D497/04 ,  C07D513/04

摘要： The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.

公开(公告)号：EP1984353A1

公开(公告)日：2008-10-29

申请号：EP07716912.6

申请日：2007-01-22

申请人： Amgen, Inc

发明人： CEE, Victor J. ,  DEAK, Holly L. ,  DU, Bingfan ,  GEUNS-MEYER, Stephanie D. ,  HODOUS, Brian L. ,  NGUYEN, Hanh Nho ,  OLIVIERI, Philip R. ,  PATEL, Vinod F. ,  ROMERO, Karina ,  SCHENKEL, Laurie

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D497/04 ,  A61K31/502 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D497/04

摘要： The present invention relates to chemical compounds having a general formula (I) wherein A1, A2, C1, C2, D, L1, L2, Z and R1-8 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

公开(公告)号：EP1888594A2

公开(公告)日：2008-02-20

申请号：EP06813185.3

申请日：2006-05-16

申请人： WISYS TECHNOLOGY FOUNDATION, INC.

发明人： COOK, James M. ,  HAN, Dongmei ,  CLAYTON, Terry

IPC分类号： C07D497/04 ,  C07D487/14 ,  A61K31/5517 ,  A61P25/28

CPC分类号： C07D487/04 ,  C07D487/14 ,  C07D519/00

摘要： The present invention provides imidazobenzodiazepine derivatives and methods for the prevention and/or treatment of memory deficit related conditions and/or enhancement of cognizance. In a preferred embodiment, the invention includes compounds, salts and prodrugs thereof for the prevention and/or treatment of these conditions.

公开(公告)号：EP1863774A2

公开(公告)日：2007-12-12

申请号：EP06748934.4

申请日：2006-03-30

申请人： Third-Order Nanotechnologies, Inc.

发明人： GOETZ, Frederick J.

IPC分类号： C07D241/36 ,  C07D271/00 ,  C07D487/00 ,  C07D491/00 ,  C07D495/00 ,  C07D497/00 ,  C07D498/00 ,  C07D513/00

CPC分类号： G02F1/3612 ,  C07D487/04 ,  C09B17/02

摘要： NLO chromophores for the production of first-, second, third- and/or higher order polarizabilities of the form of Formula I: R ( P ) Acc1 .Q4- Acc3 S/ ^Q1' n Acc4 Y A Formula I and the commercially acceptable salts, solvates and hydrates thereof, wherein n, p, X , Acc Z1*4, Q1'5, π\ D and A have the definitions provided herein.

公开(公告)号：EP1796467A2

公开(公告)日：2007-06-20

申请号：EP05800794.9

申请日：2005-09-23

申请人： JANSSEN PHARMACEUTICA N.V.

发明人： LIU, Jian ,  PATCH, Raymond, J. ,  PLAYER, Mark, R.

IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  C07D471/00 ,  C07D487/00 ,  C07D491/00 ,  C07D495/00 ,  C07D497/00

CPC分类号： C07D487/04

摘要： The invention is directed to compounds of Formula (I): Wherein Q, Y, A are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein kinases, especially Aurora-1, Aurora-2 and Aurora-3 kinases.

公开(公告)号：EP1794137A2

公开(公告)日：2007-06-13

申请号：EP05799606.8

申请日：2005-09-26

申请人： Kosan Biosciences, Inc.

发明人： SANTI, Daniel, V. ,  REID, Ralph, C. ,  HUTCHINSON, Richard, C. ,  SUNDERMANN, Kurt, F. ,  LAU, Janice

IPC分类号： C07D267/22 ,  C07D281/18 ,  C07D291/00 ,  C07D337/16 ,  C07D487/00 ,  C07D513/00 ,  C07D245/00 ,  C07D327/00 ,  C07D343/00 ,  C07D411/00 ,  C07D497/00 ,  C07D339/00 ,  C07D341/00 ,  C07D409/00 ,  C07D495/00 ,  C07D337/12 ,  C07D405/00 ,  C07D313/00 ,  C07D407/00 ,  C07D493/00 ,  C07D323/00

CPC分类号： A61K31/33 ,  A61K31/365 ,  A61K31/4178 ,  A61K31/5377 ,  C07D493/04

摘要： Resorcylic acid lactones having a C5-C6 cis double bond and a ketone at C7 and other compounds capable of Michael adduct formation are potent and stable inhibitors of a subset of protein kinases having a specific cysteine residue in the ATP binding site.

公开(公告)号：EP1784410A2

公开(公告)日：2007-05-16

申请号：EP05786571.9

申请日：2005-08-09

申请人： GLAXO GROUP LIMITED

发明人： MILLER, William, Henry ,  SEEFELD, Mark, Andrew ,  ROUSE, Meagan, B.

IPC分类号： C07D497/04 ,  C07D498/04 ,  C07D487/04 ,  A61K31/4375 ,  A61K31/5365 ,  A61K31/542

CPC分类号： C07D471/04 ,  C07D519/00

摘要： Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

公开(公告)号：EP1471056A4

公开(公告)日：2006-10-11

申请号：EP03700504

申请日：2003-01-09

申请人： TAKEDA PHARMACEUTICAL

发明人： KAWAKAMI JUN-ICHI ,  NAKAMOTO KOJI ,  NUWA SHIGERU ,  HANDA SYOJI ,  MIKI SHOKYO

IPC分类号： C07D233/64 ,  A61K31/4164 ,  A61K31/4188 ,  A61P13/08 ,  A61P15/00 ,  A61P17/14 ,  A61P35/00 ,  A61P43/00 ,  C07D213/55 ,  C07D215/12 ,  C07D233/54 ,  C07D307/16 ,  C07D307/33 ,  C07D487/04 ,  C07F3/06 ,  C07D497/04

CPC分类号： C07D233/64 ,  C07D487/04 ,  C07F3/06

摘要： A process for industrially advantageously producing a steroid C17,20-lyase inhibitor represented by the following general formula (I); and a Reformatsky reagent in a stable form which is suitable for use in the production process. Either a specific ß-hydroxy ester compound derivative obtained from a specific carbonyl compound by the Reformatsky reaction or a salt of the compound is reduced in the presence of a metal/hydrogen complex compound and a metal halide and then subjected to ring closure to thereby obtain a compound represented by the general formula (I): (I) wherein the symbols have the same meanings as defined in the description. In the Reformatsky reaction, a stable solution of the compound represented by BrZnCH2COOC2H5 or crystals of the compound represented by (BrZnCH2COOC2H5·THF)2 are useful.

公开(公告)号：EP1487836B1

公开(公告)日：2006-09-06

申请号：EP03714788.1

申请日：2003-03-07

申请人： Sanofi-Aventis Deutschland GmbH

发明人： MANERO, Javier ,  METZENTHIN, Tobias ,  GAULER, Rainer

IPC分类号： C07D471/04 ,  C07D497/04 ,  A61K31/55 ,  A61P9/10

CPC分类号： C07D471/04 ,  C07C211/63 ,  C07D513/04

摘要： The invention relates to ethane-1,2-diamino-bis[(2R)-2-bromo-3-phenylpropanoate], the production of ethane-1,2-diamino-bis[(2R)-2-bromo-3-phenylpropanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylendiamine in 2-propanol and the use of ethane-1,2-diamino-bis[(2R)-2-bromo-3-phenylpropanoate] for the production of ACE/NEP inhibitors.

公开(公告)号：EP1534702A1

公开(公告)日：2005-06-01

申请号：EP03792181.4

申请日：2003-07-08

申请人： Universita' Degli Studi Di Milano - Bicocca

发明人： ABBOTTO, Alessandro ,  BEVERINA, Luca ,  BOZIO, Renato ,  PAGANI, Giorgio, A. ,  SIGNORINI, Raffaella

IPC分类号： C07D401/14 ,  C07D497/04 ,  A61K41/00 ,  A61K49/00

CPC分类号： C07D401/14 ,  A61K41/008 ,  A61K49/0021 ,  C07D495/04

摘要： The present invention relates to new heteroaromatic compounds with high two-photon absorption activity, useful in particular as optical power limiting agents via two-photon absorption or as imaging agents in confocal laser scanning fluorescence microsopy via two-photon absorption or excitation.