公开(公告)号：EP2035000A1

公开(公告)日：2009-03-18

申请号：EP07796204.1

申请日：2007-06-14

申请人： FIBROGEN, INC.

发明人： SEELEY, Todd, W. ,  LIU, David, Y. ,  KLAUS, Stephen, J.

IPC分类号： A61K31/47 ,  A61P7/06

CPC分类号： A61K31/47

摘要： The invention relates to methods and compounds for treating anemia of cancer. In particular, methods for treating anemia of cancer in a subject having cancer, and methods for increasing reticulocytes, increasing hemoglobin, increasing hematocrit, and increasing red blood cell count in subjects having anemia of cancer, wherein such subjects are refractory to treatment with recombinant human erythropoietin (EPO) are encompassed herein.

公开(公告)号：EP2016078A2

公开(公告)日：2009-01-21

申请号：EP07760122.7

申请日：2007-04-04

申请人： FIBROGEN, INC.

发明人： DENG, Shaojiang ,  WU, Min ,  TURTLE, Eric, D. ,  HO, Wen-Bin ,  AREND, Michael, P. ,  CHENG, Heng ,  FLIPPIN, Lee A.

IPC分类号： C07D471/04 ,  C07D413/04 ,  A61K31/429 ,  A61K31/4353 ,  A61P7/06 ,  A61P9/10

CPC分类号： C07D471/04 ,  C07D513/04

摘要： The present invention relates to novel compounds of formula (I) capable of modulating the stability and/or activity of hypoxia inducible factor (HIF).

摘要翻译： 本发明涉及能够调节缺氧诱导因子（HIF）的稳定性和/或活性的新颖的式（I）化合物。

公开(公告)号：EP1942985A1

公开(公告)日：2008-07-16

申请号：EP06759197.4

申请日：2006-05-05

申请人： FIBROGEN, INC.

发明人： LANGSETMO PAROBOK, Ingrid ,  SEELEY, Todd, W. ,  STEPHENSON, Robert, C.

IPC分类号： A61P9/12 ,  A61K39/395 ,  C07K16/22

CPC分类号： C07K16/22 ,  A61K2039/505

摘要： The present invention relates to methods and agents for reducing blood pressure. Methods and agents for reducing diastolic blood pressure, for reducing systolic blood pressure, and for reducing mean arterial pressure are also provided.

公开(公告)号：EP1140964B1

公开(公告)日：2008-04-09

申请号：EP99966224.0

申请日：1999-12-14

申请人： University of Miami ,  FIBROGEN, INC.

发明人： GROTENDORST, Gary, R. ,  NEFF, Thomas, B.

IPC分类号： C07K14/475

CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/475

摘要： The present invention is directed to CTGF fragments comprising at least exon 4 or exon 5 of CTGF and having mitogenic activity. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the mitogenic activity of said CTGF fragments and to the compositions so identified.

公开(公告)号：EP1889072A2

公开(公告)日：2008-02-20

申请号：EP06759331.9

申请日：2006-05-05

申请人： FIBROGEN, INC.

发明人： JAFFA, Ayad, A. ,  USINGER, William, R.

IPC分类号： G01N33/68

CPC分类号： G01N33/6887 ,  G01N33/6893 ,  G01N2333/475 ,  G01N2800/042 ,  G01N2800/32

摘要： The present invention relates to the discovery that CTGF is a diagnostic marker indicative of increased risk for development and progression of vascular disease.

公开(公告)号：EP1715890A1

公开(公告)日：2006-11-02

申请号：EP05713358.9

申请日：2005-02-11

申请人： FIBROGEN, INC.

发明人： FLYVBJERG, Allan ,  GUO, Guangjie ,  LIU, David, Y. ,  NEFF, Thomas, B. ,  OLIVER, Noelynn, A. ,  USINGER, William, R. ,  WANG, Qingjian

IPC分类号： A61K39/39 ,  A61K39/395 ,  A61K31/00 ,  A61K38/00 ,  A61P13/12

CPC分类号： A61K38/556 ,  A61K31/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/22 ,  A61K2300/00

摘要： The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.

公开(公告)号：EP1658074A1

公开(公告)日：2006-05-24

申请号：EP04779849.1

申请日：2004-07-30

申请人： FIBROGEN, INC. ,  ISIS INNOVATION LIMITED

发明人： KLAUS, Stephen, J. ,  RATCLIFFE, Peter, J.

IPC分类号： A61K31/47 ,  A61K31/17 ,  A61K31/19 ,  A61P7/00 ,  A61P7/06 ,  A61P33/06 ,  A61P43/00

CPC分类号： A61K31/7072 ,  A61K31/17 ,  A61K31/19 ,  A61K31/47 ,  Y02A50/411

摘要： The present invention provides methods for increasing endogenous globin expression in a subject, specifically gamma-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., beta thalassemia and sickle cell disease.

公开(公告)号：EP1631591A2

公开(公告)日：2006-03-08

申请号：EP04753822.8

申请日：2004-06-02

申请人： FIBROGEN, INC.

发明人： LIN, Ai, Y. ,  NEFF, Thomas, B. ,  OLIVER, Noelynn, A. ,  USINGER, William, R. ,  WANG, Qingjian ,  YEOWELL, David, A.

IPC分类号： C07K16/22

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.

公开(公告)号：EP1487472A4

公开(公告)日：2005-11-16

申请号：EP02797195

申请日：2002-12-06

申请人： FIBROGEN INC

发明人： GUENZLER-PUKALL VOLKMAR ,  NEFF THOMAS B ,  WANG QINGJIAN ,  AREND MICHAEL P ,  FLIPPIN LEE A

IPC分类号： G01N33/50 ,  A61K31/00 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/555 ,  A61K31/63 ,  A61K33/26 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K45/00 ,  A61K45/06 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P7/06 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P43/00 ,  C07K14/47 ,  C07K14/505 ,  C12N5/06 ,  C12N9/99 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  C12Q1/34 ,  C12Q1/56

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.

公开(公告)号：EP1578431A2

公开(公告)日：2005-09-28

申请号：EP03796688.4

申请日：2003-12-05

申请人： FIBROGEN, INC.

发明人： FOURNEY, Patrick, D. ,  GUENZLER-PUKALL, Volkmar ,  KLAUS, Stephen, J. ,  LIN, Al, Y. ,  NEFF, Thomas, B. ,  SEELEY, Todd, W.

IPC分类号： A61K31/70

CPC分类号： A61K31/70 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e.g., obesity, diabetes, atherosclerosis, etc.