公开(公告)号：EP2822545A2

公开(公告)日：2015-01-14

申请号：EP13758366.2

申请日：2013-03-08

申请人： Fibrogen, Inc.

发明人： LIN, Al, Y. ,  NEFF, Thomas, B. ,  YU, Kin-Hung

IPC分类号： A61K31/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/472 ,  A61K45/06 ,  C07D217/26 ,  A61K2300/00

摘要： The present invention provides a method for treatment of high cholesterol by reducing low density lipoprotein cholesterol (LDL-C) and/or very low density Opoproiein cholesterol (VLDL-C) in subjects In need thereof by administering a compound that inhibits HIF hydroxylase activity. The method is useful, for reducing LDL cholesterol levels and total cholesterol levels even In subjects already undergoing treatment with other cholesterol-lowering medications, for example statins, fibrates, nicotinic acids and bile acid-binding resins, and in patients having chronic kidney disease or end stage renal disease,
inter alia.

公开(公告)号：EP1463823A2

公开(公告)日：2004-10-06

申请号：EP02805548.1

申请日：2002-12-06

申请人： FibroGen, Inc.

发明人： KLAUS, Stephen, J. ,  LIN, Al, Y. ,  NEFF, Thomas, B. ,  WANG, Qingjian ,  GUENZLER-PUKALL, Volkmar ,  AREND, Michael, P. ,  FLIPPIN, Lee, A.

IPC分类号： C12N15/90 ,  C12Q1/56 ,  C12Q1/34

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.

公开(公告)号：EP1578431A2

公开(公告)日：2005-09-28

申请号：EP03796688.4

申请日：2003-12-05

申请人： FIBROGEN, INC.

发明人： FOURNEY, Patrick, D. ,  GUENZLER-PUKALL, Volkmar ,  KLAUS, Stephen, J. ,  LIN, Al, Y. ,  NEFF, Thomas, B. ,  SEELEY, Todd, W.

IPC分类号： A61K31/70

CPC分类号： A61K31/70 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e.g., obesity, diabetes, atherosclerosis, etc.

公开(公告)号：EP1463823B1

公开(公告)日：2013-03-06

申请号：EP02805548.1

申请日：2002-12-06

申请人： Fibrogen, Inc.

发明人： KLAUS, Stephen, J. ,  LIN, Al, Y. ,  NEFF, Thomas, B. ,  WANG, Qingjian ,  GUENZLER-PUKALL, Volkmar ,  AREND, Michael, P. ,  FLIPPIN, Lee, A.

IPC分类号： A61K31/00 ,  A61K31/17 ,  C07K14/47 ,  C07K14/505 ,  A61K31/47 ,  A61K31/4738 ,  A61K31/63 ,  G01N33/74 ,  A61K38/17 ,  C12N15/09 ,  C12Q1/34 ,  C12Q1/56 ,  A61P7/06

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.