公开(公告)号：EP0536399A1

公开(公告)日：1993-04-14

申请号：EP91910447.1

申请日：1991-06-07

申请人： ZERIA PHARMACEUTICAL CO., LTD.

发明人： OKUBO, Akihiro, Zeria Pharmac. Co., Ltd. ,  NISHIOKA, Hiroyasu, Zeria Pharmac. Co., Ltd. ,  ARAI, Heihachiro, Zeria Pharamc. Co., Ltd. ,  TANAKA, Yoshiaki, Zeria Pharmac. Co., Ltd. ,  KATO, Hisayoshi, Zeria Pharmac. Co., Ltd. ,  NAKATA, Naoki, Zeria Pharmac. Co., Ltd.

IPC分类号： C07D207/16 ,  A61K31/40 ,  A61K31/425 ,  C07D277/06 ,  C07D417/14 ,  C07D405/14 ,  C07D417/06

CPC分类号： C07D405/14 ,  C07D207/16 ,  C07D277/06 ,  C07D417/06 ,  C07D417/14

摘要： An arylalkanoylamine derivative represented by general formula (I), excellent in a prolyl endopeptidase inhibitory action and resistances to hypoxia and amnesia; and a drug for improving mneme, cerebral circulation and cerebral metabolism, containing the same as the active ingredient, wherein A represents indanyl, indenyl, 1,2,3,4-tetrahydronaphthalenyl or benzofuranyl; m is an integer of 0 to 5; Z represents hydroxymethyl, formyl, nitrile, hydroxyiminomethyl, semicarbazonomethyl or dialkoxymethyl and X and Y may be the same or different from each other and each represents methylene or sulfur, provided that the case where A represents indanyl, indenyl or 1,2,3,4-tetrahydronaphthalenyl, X and Y represent both methylene, and Z represents hydroxymethyl or formyl is excluded.

摘要翻译： 通式（I）表示的芳基烷酰胺衍生物，脯氨酰内肽酶抑制作用优异，对缺氧和遗忘有抵抗性; 其中A代表茚满基，茚基，1,2,3,4-四氢萘基或苯并呋喃基;以及含有相同活性成分的用于改善病态，脑循环和脑代谢的药物。 m是0至5的整数; Z代表羟甲基，甲酰基，腈基，羟基亚氨基甲基，氨基羰基甲基或二烷氧基甲基，X和Y可以相同或不同，各自代表亚甲基或硫，条件是A代表茚满基，茚基或1,2,3， 4-四氢萘基，X和Y代表两个亚甲基，Z代表羟甲基或甲酰基。

公开(公告)号：EP0424528A1

公开(公告)日：1991-05-02

申请号：EP89905187.4

申请日：1989-05-01

申请人： ZERIA PHARMACEUTICAL CO., LTD.

发明人： OGURA, Kuniyoshi, Zeria Pharmaceutical Co., Ltd. ,  AOTSUKA, Tomoji, Zeria Pharmaceutical Co., Ltd. ,  TORIZUKA, Motoki, Zeria Pharmaceutical Co., Ltd. ,  SOEDA, Mitsuo, Zeria Pharmaceutical Co., Ltd. ,  TANAKA, Yoshiaki, Zeria Pharmaceutical Co., Ltd. ,  KATO, Hisayoshi, Zeria Pharmaceutical Co., Ltd. ,  MIURA, Naoyoshi, Zeria Pharmaceutical Co., Ltd. ,  NAKATA, Naoki, Zeria Pharmaceutical Co., Ltd. ,  MORITA, Hikaru, Zeria Pharmaceutical Co., Ltd. ,  OKUBO, Akihiro, Zeria Pharmaceutical Co., Ltd.

IPC分类号： C07D277/04 ,  C07D211/70 ,  C07D295/18 ,  A61K31/40 ,  A61K31/425 ,  A61K31/435 ,  A61K31/54 ,  C07D207/20

CPC分类号： C07D295/185 ,  C07D207/20 ,  C07D211/70 ,  C07D277/04

摘要： Drugs for improving cerebral circulation, cerebral metabolism and memory containing as the active ingredient a phenylalkanoylamine derivative or its salt represented by general formula (I) (wherein A represents a 1,3-thiazolin-3-yl group, a 1,2,3,6-tetrahydropyridin-1-yl group, a morpholino group, a thiomorpholin-4-yl group or a 3-pyrrolin-1-yl group, R¹ and R² may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group or (α) (wherein R³ and R⁴ each represents a lower alkyl group or, when taken together, they represent a 5- or 6-membered heterocyclic group together with the nitrogen atom), and n represents an integer of 2 to 6) and novel phenylalkanoylamine derivatives among the compounds represented by (I), and a process for their preparation are disclosed. The above drugs are useful for treating sequelae of cerebral hemorrhage, sequelae of cerebral infarction, arterial aclerosis of brain, sequelae of subarachnoidal hemorrhage, sequelae of head trauma, sequelae of cerebral operation, dementia of cerebral vessel origin, Parkinson's disease, Alzheimer's disease, Pick's disease, sequelae of hypoxia, alcoholic cerebral diseases, etc.

摘要翻译： 用于改善脑循环，大脑代谢和记忆的药物，其含有通式（I）表示的苯基烷酰基胺衍生物或其盐作为活性成分（其中A表示1,3-噻唑啉-3-基，1,2,3 ，6-四氢吡啶-1-基，吗啉代基，硫代吗啉-4-基或3-吡咯啉-1-基，R 1和R 2可以相同或不同，各代表氢原子，卤素 低级烷基，低级烷氧基，硝基，氨基或（α）（其中R 3和R 4各自代表低级烷基，或者当合在一起时，它们代表5或6元杂环 与氮原子一起形成的基团），n表示2至6的整数）和由（I）表示的化合物中的新型苯基烷酰基胺衍生物及其制备方法。 上述药物可用于治疗脑出血后遗症，脑梗塞后遗症，脑动脉硬化症，蛛网膜下腔出血后遗症，头部创伤后遗症，脑手术后遗症，脑血管源性痴呆，帕金森病，阿尔茨海默氏病，Pick's 疾病，缺氧后遗症，酒精性脑病等。

公开(公告)号：EP0381055A1

公开(公告)日：1990-08-08

申请号：EP90101490.2

申请日：1990-01-25

申请人： RICOM CORPORATION ,  ZERIA PHARMACEUTICAL CO., LTD. ,  MITSUI & CO., LTD.

发明人： Ishibashi, Sadami ,  Hamaya, Tadao, ,  Imai, Tadashi ,  Iijima, Massao

IPC分类号： A61K7/26 ,  A61K7/32 ,  A61K35/84 ,  A23L1/28 ,  A61L9/01

CPC分类号： A61K8/9706 ,  A23L5/00 ,  A23L31/00 ,  A61K8/34 ,  A61K8/35 ,  A61K8/365 ,  A61K8/60 ,  A61K8/676 ,  A61L9/01 ,  A61Q11/00 ,  A61Q15/00

摘要： A deodorizer comprises a hydrophilic solvent extract of fruit-­bodies of champignon mushroom or powder of the extract as an effective component. The extract of champignon mushroom used as an effective component can be prepared by a method which comprises the step of immersing the mushroom in a hydrophilic solvent at a temperature ranging from 60 to 100° C for 15 minutes to 2 hours to perform extraction. The extract can further be treated to obtain the effective components in the form of powder. The extract and the powder thereof can be used as an effective component of a deodorizer capable of oral intake, which serves as a deodorizer for preventing bad smell of environment or an agent for preventing foul breath, which can also be used in foods for eating or drinking to prevent giving out of bad smell emitted from cookings such as those containing garlic and leek as well as cooked fish, which can prevents giving out of bad smell after taking such cookings, and which can be involved in metabolism to thus suppress the giving out of bad smell from urine and feces discharged after eating and drinking such foods.

摘要翻译： 除臭剂包括香菇的果实的亲水性溶剂提取物或提取物的粉末作为有效成分。 用作有效成分的香菇菇的提取物可以通过包括以下步骤的方法制备：将蘑菇浸入亲水性溶剂中，温度为60〜100℃，持续15分钟〜2小时，进行萃取。 可以进一步处理提取物以获得粉末形式的有效成分。 提取物及其粉末可以用作能够口服的除臭剂的有效成分，其作为用于防止臭味的除臭剂或用于防止臭味的药剂，其也可用于食用食品或 饮用以防止排出的诸如含有大蒜和韭菜以及煮熟的鱼类的烹饪物质产生的不良气味，其可以防止在进行这种烹饪之后发出不良气味，并且可以参与新陈代谢从而抑制发出 食用和饮用这些食物后尿液和粪便排出的气味不好。