公开(公告)号：EP1268529A2

公开(公告)日：2003-01-02

申请号：EP01922443.5

申请日：2001-03-16

申请人： City of Hope

发明人： DIAMOND, Don, J.

IPC分类号： C07K14/005 ,  A61K39/12 ,  C07K16/08

CPC分类号： C07K14/005 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/57 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/24143 ,  G01N33/56972

摘要： The invention provides a plurality of peptides (and immunologically functional variants thereof) which are immunogenic epitopes recognized by CD8+ class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent human cytomegalovirus (HCMV) infection. The peptides are capable of activating CTLs and CTLps in the absence of active viral replication, and thus are useful for eliciting a cellular immune response against HCMV by normal and immunodeficient subjects. Peptide and lipopeptide vaccines, with and without adjuvants, also are disclosed. Cellular vaccines comprising the peptides form a further embodiment of this invention.

公开(公告)号：EP0627932B1

公开(公告)日：2002-05-08

申请号：EP92924181.8

申请日：1992-11-04

申请人： CITY OF HOPE

发明人： WU, Anna, M.

IPC分类号： C12N15/13 ,  C07K16/46 ,  C07K16/30 ,  C12N1/21

CPC分类号： C07K16/468 ,  C07K16/00 ,  C07K16/3007 ,  Y10S530/866 ,  Y10S530/867

摘要： An antigen binding protein construct or "minibody" which includes the VL and VH domains of a native antibody fused to the hinge region and CH3 domain of the immunoglobulin molecule is described. Minibodies are small versions of whole antibodies which encode in a single chain the essential elements of a whole antibody. Minibodies are expressed by host cells transformed with minibody genes.

公开(公告)号：EP1179049A2

公开(公告)日：2002-02-13

申请号：EP00937534.6

申请日：2000-05-12

申请人： City of Hope

发明人： SHIH, Chu-Chih

IPC分类号： C12N5/08 ,  C12N5/06 ,  C07K14/47 ,  C12P21/00

CPC分类号： C12N5/0647 ,  A61K2035/124 ,  C07K14/4718 ,  C12N2501/125 ,  C12N2501/22 ,  C12N2501/2303 ,  C12N2501/2306 ,  C12N2501/235 ,  C12N2502/1394

摘要： A method for the ex-vivo expansion of mammalian hematopoietic stem cells (HSC) comprises culturing isolated HSC in a culture system comprising a culture medium in the presence of a stem cell expansion promoting factor (SCEPF) which may be obtained by culturing murine stromal cells in the presence of an amount of leukemia inhibitory factor (LIF) sufficient to stimulate the production and secretion of said expansion promoting factor.

公开(公告)号：EP0575463B1

公开(公告)日：2001-10-04

申请号：EP92907353.4

申请日：1992-02-07

申请人： CITY OF HOPE

发明人： BAILEY, Jerome, M. ,  SHIVELY, John, E.

IPC分类号： G01N33/68 ,  C07K1/10

CPC分类号： C07K1/128 ,  G01N33/6821

公开(公告)号：EP1007542A1

公开(公告)日：2000-06-14

申请号：EP98932746.5

申请日：1998-06-15

申请人： CITY OF HOPE

发明人： GRAHAM, Kenneth, S. ,  SHIVELY, John, E.

IPC分类号： C07K1/12 ,  G01N33/68

CPC分类号： C07K1/12 ,  G01N33/6821

摘要： A method for C-Terminal degradation of peptides and proteins involves forming a thiohydantoin derivative of the C-Terminal amino acid and then cleaving the derivatized amino acid by reaction with methoxide or methiolate ions.

公开(公告)号：EP0565674B1

公开(公告)日：1999-01-07

申请号：EP92922231.3

申请日：1992-10-20

申请人： CITY OF HOPE

发明人： ROBERTS, Eugene

IPC分类号： A61K31/56 ,  A61K31/57

CPC分类号： A61K31/57

摘要： Administration of pregnenolone or pregnenolone sulfate to enhance memory and improve the quality of life in mammals, including humans, is disclosed.

公开(公告)号：EP0641352B1

公开(公告)日：1997-06-04

申请号：EP94909714.1

申请日：1994-02-17

申请人： CITY OF HOPE

发明人： SOWERS, Lawrence, C.

IPC分类号： C07H19/073 ,  C07H21/04

CPC分类号： C07H19/06 ,  C07H19/056 ,  C07H19/10

摘要： 4-Ethoxy 5-fluoro 2'deoxyuridine and its use to synthesize oligonucleotides containing 5-fluoro 2'deoxyuridine are disclosed.

公开(公告)号：EP0732409A2

公开(公告)日：1996-09-18

申请号：EP95203360.3

申请日：1989-08-16

申请人： CITY OF HOPE

发明人： Scanlon, Kevin J.

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P19/34 ,  C12Q1/02 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  B82Y5/00 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  Y10T436/143333

摘要： Changes in tumor cell RNA and DNA are utilized to detect the progression and the temporal changes in resistance to chemotherapy in human tumors. The present invention provides a method for determining whether human cancer cells are sensitive or resistant to a particular drug, to allow for early detection of drug resistance in order to improve significantly the efficiency of a cancer chemotherapy protocol. The method involves the detection of DNA sequences indicative of drug resistance.

摘要翻译： 肿瘤细胞RNA和DNA的变化被用于检测人类肿瘤化疗耐药进展和时间变化。 本发明提供了一种用于确定人类癌细胞是否对特定药物敏感或抗性的方法，以便能够早期检测耐药性，以显着提高癌症化疗方案的效率。 该方法涉及检测指示耐药性的DNA序列。

公开(公告)号：EP0706423A1

公开(公告)日：1996-04-17

申请号：EP94914009.0

申请日：1994-04-01

申请人： CITY OF HOPE

发明人： WILSON, Anthony, D.

IPC分类号： F16K21 ,  B05B1 ,  B05B17 ,  F16K31

CPC分类号： F16K31/005

摘要： A micro-volume fluid injector (10) includes a three-part housing (100, 200, 300) with a conically-shaped recess (106) terminating in an outlet orifice (108) and a conically-shaped plunger (230) which is movable within the recess (106). A piezoelectric disk (270) is secured to the plunger (230) so as to move the plunger in a reciprocating motion to pump the fluid through the orifice (108).

摘要翻译： 微量流体注射器（10）包括具有终止于出口孔（108）的圆锥形凹部（106）和圆锥形柱塞（230）的三部分壳体（100,200,300） 可在凹槽（106）内移动。 压电盘（270）固定在柱塞（230）上，以便使柱塞往复运动以泵送流体通过孔（108）。

公开(公告)号：EP0641352A1

公开(公告)日：1995-03-08

申请号：EP94909714.0

申请日：1994-02-17

申请人： CITY OF HOPE

发明人： SOWERS, Lawrence, C.

IPC分类号： C07H19

CPC分类号： C07H19/06 ,  C07H19/056 ,  C07H19/10

摘要： 4-Ethoxy 5-fluoro 2'deoxyuridine and its use to synthesize oligonucleotides containing 5-fluoro 2'deoxyuridine are disclosed.