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101.发明公开AMORPHOUS MIRABEGRON AND PROCESSES FOR CRYSTAL FORMS OF MIRABEGRON 审中-公开AMORPHES MIRABEGRON UND VERFAHRENFÜRKRISTALLINE FORMEN VON MIRABEGRON
公开(公告)号：EP2709993A2
公开(公告)日：2014-03-26
申请号：EP12785575.7
申请日：2012-05-17
发明人： PEDDY, Vishweshwar , BOGE, Rajesham
IPC分类号： C07D277/40 , A61K31/426 , A61P13/10 , A61P13/00 , A61P3/10
CPC分类号： A61K31/426 , C07D277/40
摘要： Aspects of the present invention relate to amorphous form of mirabegron, amorphous solid dispersion of mirabegron, process for its preparation, processes for preparation of a form crystal and β form crystal of mirabegron and pharmaceutical composition thereof.
摘要翻译： 本发明的方面涉及mirabegron的无定形形式，mirabegron的无定形固体分散体，其制备方法，形式晶体的制备方法和＆bgr; 形成mirabegron的晶体及其药物组合物。
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公开(公告)号：EP2610239A1
公开(公告)日：2013-07-03
申请号：EP12008580.8
申请日：2012-12-21
IPC分类号： C07C209/68 , C07C209/84 , C07C211/42
CPC分类号： C07C209/68 , C07C209/84 , C07C211/42 , C07C2602/08
摘要： The present application provides improved processes for crystallization of Rasagiline hemitartrate having improved filterability.
摘要翻译： 本申请提供了具有改进的过滤性的改善的雷沙吉兰酒石酸盐的结晶方法。
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公开(公告)号：EP2598889A2
公开(公告)日：2013-06-05
申请号：EP11813184.6
申请日：2011-07-28
发明人： SRINIVASAN, Santhanakrishnan , RAMASAMY, Karthik , NALLAM, Chakravarthula Kalyan Narasimham , KOMARAVOLU, Yagna Kiran Kumar , KALLAM, Sudheer Reddy , GANJI, Bala Harsha Vardhan , BATHOJU, Ravindra Chary , DEVI, Basanthi
CPC分类号： C07K2/00 , B01D15/34 , G01N30/02 , Y10T436/105831 , Y10T436/255
摘要： Aspects of the present application relate to molecular weight markers of glatiramer acetate for accurate determination of the average molecular weight of glatiramer acetate.
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104.发明公开PROCESS FOR THE PREPARATION OF A SINGLE ENANTIOMER OF 3-AMINOPIPERIDINE DIHYDROCHLORIDE 审中-公开方法用于生产单一对映体OFF 3-氨基二盐酸盐
公开(公告)号：EP2582671A2
公开(公告)日：2013-04-24
申请号：EP11796521.0
申请日：2011-06-17
发明人： MEEK, Graham Andrew , KUNHIMON, Syam Kumar Unniaran Purakkal , SHANKAR, R. , DAHANUKAR, Vilas Hareshwar , MOHAN, TH. Krishna , WAGH, Manoj Balu , PAL, Abir Kumar , MEESALA, V. Madhu Babu , SHRIVASTAVA, Sonmit
IPC分类号： C07D211/56 , B01J23/44 , C07B55/00
CPC分类号： C07D211/02 , B01J21/18 , B01J23/44 , C07B57/00 , C07D211/56
摘要： A process comprising: (a) reduction of N-acetyl-3-aminopyridine (2): or its salt in the presence of hydrogen and a palladium catalyst deposited on solid support; (b) converting racemic N-acetyl-3-aminopiperidine (3) or its salt produced in step (a) to rac-3-aminopiperidine (rac-4) or its salt; (c) resolution of the racemic 3-aminopiperidine (rac-4) or its salt produced in step (b) with a chiral acid.
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105.发明公开Processes for the preparation of agomelatine and its intermediates 审中-公开Prozesse zur Herstellung von Agomelatin和seine Zwischenstoffe
公开(公告)号：EP2562151A1
公开(公告)日：2013-02-27
申请号：EP12181650.8
申请日：2012-08-24
发明人： Cherukupally, Praveen , Vyala, Sunitha , Vujjini, Satish Kumar , Badarla, Venkata Krishna Rao , Kandala, Sreenadha Charyulu , Datla, Venkata Rama Krishnam Raju , Nalivela, Venu
IPC分类号： C07C29/09 , C07C35/52 , C07C41/16 , C07C43/192 , C07C69/65 , C07C231/02 , C07C233/21 , C07C233/90
CPC分类号： C07C67/297 , C07C37/0555 , C07C41/16 , C07C67/293 , C07C69/65 , C07C213/02 , C07C231/02 , C07C233/91 , C07C43/225 , C07C217/60 , C07C233/18 , C07C39/38
摘要： Aspects of the present application relate to processes for the preparation of agomelatine and its intermediates which are used in manufacturing process of agomelatine.
摘要翻译： 本申请的方面涉及用于制备agomelatine制造过程中的agomelatine及其中间体的方法。
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公开(公告)号：EP2519537A2
公开(公告)日：2012-11-07
申请号：EP10844265.8
申请日：2010-12-28
摘要： The invention describes a method for protein purification. More particularly, the invention relates to a purification process comprising protein A chromatography and anion exchange chromatography wherein protein A chromatography eluate is further purified by anion exchange chromatography at similar pH or at a pH less than or equal to 6.
摘要翻译： 本发明描述了一种用于蛋白质纯化的方法。 更具体地说，本发明涉及包含蛋白A层析和阴离子交换层析的纯化方法，其中蛋白A层析洗脱液通过阴离子交换层析在相似的pH或小于或等于6的pH下进一步纯化。
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公开(公告)号：EP2456871A2
公开(公告)日：2012-05-30
申请号：EP10802943.0
申请日：2010-07-23
IPC分类号： C12N15/63 , C12N15/12 , C12P21/04 , C07K14/505
CPC分类号： C07K14/505 , C12N5/0018 , C12N2500/74 , C12N2500/76 , C12N2501/33 , C12N2533/30 , C12P21/005
摘要： The present invention provides methods of increasing the levels of low pI isoforms of expressing erythropoiesis stimulating protein in media containing metal ions, to improve product quality.
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公开(公告)号：EP2424845A2
公开(公告)日：2012-03-07
申请号：EP10772482.5
申请日：2010-04-26
IPC分类号： C07D251/02 , C07D405/04 , C07D253/02
CPC分类号： C07D251/16 , C07H13/12 , C07H15/04 , C07H19/12
摘要： The present application relates to processes for the preparation and purification of decitabine structurally represented by formula (I): and to processes for the preparation of a crystalline form of decitabine.
摘要翻译： 本申请涉及由式（I）结构表示的地西他滨的制备和纯化方法：以及制备地西他滨结晶形式的方法。
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公开(公告)号：EP2364312A2
公开(公告)日：2011-09-14
申请号：EP09826616.6
申请日：2009-11-10
发明人： KATKAM, Srinivas , SAGYAM, Rajeshwar Reddy , SUNKARA, Vishnuvardhan , MUNAGALA, Sridhar , MUTTAVARAPU, Murali Mohan
IPC分类号： C07D453/02 , C07D487/08 , C07D401/14 , C07D403/14
CPC分类号： C07D453/02
摘要： Processes for the preparation of palonosetron hydrochloride and its crystalline forms.
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公开(公告)号：EP2345408A2
公开(公告)日：2011-07-20
申请号：EP11250010.3
申请日：2011-01-07
发明人： Kumar, Ghosh Pradip , Singh, Rai Amrinder , Bijayananda, Sahoo , Vashdev, Nihalani Girish , Premchand, Agrawal Pratit , Suryakumar, Jayanthi , Venkateswarlu, Vobalaboina
IPC分类号： A61K9/28 , A61K9/48 , A61K9/50 , A61K31/4439 , A61K9/20
CPC分类号： A61K9/5078 , A61K9/2081 , A61K9/284 , A61K9/2886 , A61K9/5026 , A61K9/5031 , A61K9/5047 , A61K31/4439
摘要： Pharmaceutical formulations comprise inert cores that are coated with a composition comprising an acid labile drug, further sequentially coated with a barrier or intermediate layer and an enteric coating layer. Coated cores may be further formulated to produce tablets or capsules.
摘要翻译： 药物制剂包含用包含酸不稳定药物的组合物涂覆的惰性核心，进一步依次涂覆有阻隔层或中间层和肠溶衣层。 可以进一步配制包被芯以产生片剂或胶囊。
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