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公开(公告)号：EP1882033A2
公开(公告)日：2008-01-30
申请号：EP06770393.4
申请日：2006-05-12
摘要： The subject invention provides materials and methods useful in regulating blood flow. In a preferred embodiment, the subject invention provides peptides that are able to enhance nitric oxide (NO) activity and/or elevate cellular guanosine monophosphate (cGMP). Through these mechanisms, the subject invention can be used advantageously to effect vasorelaxation, thereby providing therapeutic benefit in a variety of contexts. In a specific embodiment the subject invention provides novel peptides that have been found to enhance the activity of endothelial cell nitric oxide synthase eNOS). These peptides have also been found to reduce the cGMP-specific phosphodiesterase activity.
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公开(公告)号：EP1812821A1
公开(公告)日：2007-08-01
申请号：EP05817277.6
申请日：2005-10-20
发明人： REYNOLDS, John, R.
IPC分类号： G02F1/15
CPC分类号： H01L27/3232 , G02F1/155
摘要： A combined electrochromic/electroluminescent device includes at least one pixel 101-104. Each pixel includes a substrate 107 having an electrically conductive surface 105, and an electrochemically active counter electrode layer 110 disposed on the electrically conductive surface. An electrolyte layer 115 which provides electrolytes is disposed on the counter electrode 110. An electrically conductive layer 125 is disposed on the electrolyte layer 115. An electroactive layer 130 is disposed on the electrically conductive layer 125, the electroactive layer providing both electroluminescence and an electrochromically active working electrode, wherein the electrically conductive layer 125 provides transport of electrolytes therethrough.
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公开(公告)号：EP1797433A1
公开(公告)日：2007-06-20
申请号：EP05814933.7
申请日：2005-09-29
申请人： University of Florida Research Foundation, Inc. , THE UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH
IPC分类号： G01N33/60
CPC分类号： G01N33/60 , Y10T436/143333
摘要： The subject invention provides novel isotope-labeled dinitrophenylhydrazines (DNPHs) and methods for their use in detecting and/or quantifying carbonyl groups in proteins and other analytes. In particular, the present invention provides novel methods for identifying biomarkers of oxidative stress, which can be used to either forecast or detect diseases and/or conditions associated with oxidative stress. In one embodiment of the invention, isotope-labeled DNPHs are derived from [13C6]chlorobenzene.
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104.发明公开
公开(公告)号：EP1778261A2
公开(公告)日：2007-05-02
申请号：EP05780481.7
申请日：2005-07-21
IPC分类号： A61K36/18
CPC分类号： A61K31/519 , A61K31/426 , A61K31/4439
摘要： Disclosed herein are methods of delaying the onset or treating diabetes that comprises administering a uric acid lowering agent. The inventors have made the remarkable discovery that elevated uric acid levels are not a corollary to insulin resistance, but rather a primary mediator of insulin resistance. Specifically exemplified are methods that involve administering to a patient susceptible to development of diabetes a composition comprising a uric acid lowering agent in a regimen that maintains serum uric acid levels below at least 5.2 to 5.5 mg/dl.
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105.发明公开
公开(公告)号：EP1723250A2
公开(公告)日：2006-11-22
申请号：EP05723958.4
申请日：2005-02-25
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/567
CPC分类号： C12N15/1051
摘要： The present invention provides methods and compositions for performing functional genomics and gene trapping using haploid cells, including haploid or hypodiploid vertebrate cells. The present invention further provides methods for identifying genes involved in cellular signaling pathways.
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106.发明公开USE OF MOLT-ACCELERATING COMPOUNDS, ECDYSTEROIDS, ANALOGS THEREOF, AND CHITIN SYNTHESIS INHIBITORS FOR CONTROLLING TERMITES 有权态度加速化合物的用途，蜕皮类固醇您的模拟和CHITINSYNTHESEHEMMERN防治白蚁
公开(公告)号：EP1715740A1
公开(公告)日：2006-11-02
申请号：EP05713707.7
申请日：2005-02-17
CPC分类号： A01N47/34 , A01N43/90 , A01N45/00 , A01N61/00 , Y10S424/11 , A01N37/28 , A01N25/006 , A01N37/40 , A01N43/16 , A01N49/00 , A01N2300/00
摘要： The subject invention relates in part to the oral administration of ecdysteroids for controlling subterranean termites. Preferred ecdysteroids for use according to the subject invention are ecdysone, certain ecdysone analogs, and 20-hydroxyecdysone, for example. In some preferred embodiments, one or more of these compounds is used in a termite bait in combination with one or more chitin synthesis inhibitors. Thus, the subject invention also relates in part to controlling termites by the use of a chitin synthesis inhibitor (CSI), such as hexaflumuron and/or noviflumuron, together with an ecdysteroid (and analogs thereof) or molt-accelerating compound (MAC), such as halofenozide. The subject invention also relates to mixtures comprising these two active ingredients. The MAC / ecdysteroid analog induces a preliminary molting event in termite workers (they could not complete the molting), which then allows the CSI to further disrupt the molt and cause mortality. The combination of these active ingredients, causing accelerated molting together with inhibition of chitin synthesis, is surprisingly shown herein to enhance activity against termites, as compared to either group of compounds alone.
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公开(公告)号：EP1142475B1
公开(公告)日：2006-08-09
申请号：EP01112312.2
申请日：1993-05-26
发明人： SU, Nan-Yao , Burns, Kevin J.
CPC分类号： A01M1/2011 , A01M1/026 , A01M2200/011 , A01N25/006 , Y02A40/166
摘要： The subject invention pertains to materials and methods useful for management of certain pests. The invention is particularly well suited for the control of social insect pests and, particularly, termites. The invention concerns unique toxicant-containing matrices as well as apparatuses for monitoring pest activity and presenting a toxicant. The invention is useful as part of an Integrated Pest Management Program and can greatly reduce the introduction of harmful chemicals into the environment.
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公开(公告)号：EP1682075A2
公开(公告)日：2006-07-26
申请号：EP04810542.3
申请日：2004-11-05
IPC分类号： A61K6/00
CPC分类号： C12N5/0623 , C12N2500/84 , C12N2501/11 , C12N2501/115
摘要： Systems and methods have been developed for large-scale propagation and differentiation of populations of neurons and glia from neural precursor cells derived from postnatal brain. Under culture conditions containing pituitary extract and mitogenic factors, cells derived from neural stem cells can be attached to a substrate, maintained and serially passaged in culture. Upon removal of mitogenic factors, clusters of neural progenitor cells can be induced that co-express markers of neural stem cells and immature neurons. Unlimited numbers of cells at characterized stages of neurogenesis can be produced. Upon maturation, neuronal cells extend processes and differentiate into mature neuronal phenotypes capable of generating action potentials.
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公开(公告)号：EP1678651A2
公开(公告)日：2006-07-12
申请号：EP04794451.7
申请日：2004-10-07
IPC分类号： G06G7/00
CPC分类号： G06N7/08
摘要： A dynamically configurable logic gate can include a controller (110) configured to provide a first threshold reference signal; an adder (115) configured to sum the first threshold reference signal and at least one input signal to generate a summed signal; a chaotic updater (105) configured to apply a nonlinear function to the summed signal; and a subtractor (120) configured to determine an output signal by taking a difference between a second threshold reference signal and the processed summed signal from the chaotic updater (105). The logic gate can operate as one of a plurality of different logic gates responsive to adjusting at least one of the threshold reference signals.
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公开(公告)号：EP1586344A3
公开(公告)日：2006-07-05
申请号：EP05010602.0
申请日：2000-06-30
IPC分类号： A61M16/00
CPC分类号： G06F19/3481 , A61B5/0205 , A61B5/0836 , A61B5/087 , A61B5/7264 , A61B5/7267 , A61M16/0051 , A61M16/026 , A61M16/12 , A61M2016/0021 , A61M2016/0036 , A61M2205/3553 , A61M2230/06 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/435 , A61M2230/50 , G06F19/00 , G06F19/3456 , G16H40/63 , Y10S128/924 , Y10S128/925 , A61M2230/005
摘要： Embodiments of the present invention include a system and method for monitoring the ventilation support provided by a ventilator (20) that is supplying a breathing gas to a patient (p) via a breathing circuit (22) that is in fluid communication with the lungs of the patient (p). The ventilator (20) has a plurality of selectable ventilator setting controls (30) governing the supply of ventilation from the ventilator (20), each setting control (30) selectable to a level setting. The ventilator support monitor system (10) preferably receives at least one ventilator setting parameter signal (42), each ventilator setting parameter signal (42) indicative of the level settings of one ventilator setting control (30), monitors a plurality of sensors (52-58), each sensor (52-58) producing an output signal (51) indicative of a measured ventilation support parameter, to determine the sufficiency of the ventilation support received by the patient (p), and determines the desired level settings of the ventilator setting controls (30) in response to the received ventilator setting parameter signal (42) and the output signals (51). The ventilator support monitor system (10) preferably utilizes a trainable neural network (82) to determine the desired level settings of the ventilator setting controls (30).
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