公开(公告)号：EP0839056B1

公开(公告)日：2003-05-07

申请号：EP96922444.3

申请日：1996-06-06

申请人： Mallinckrodt Inc.

发明人： DUNN, Thomas, Jeffrey ,  WHITE, David, H. ,  KNELLER, Mills, Thomas ,  JONES, Michelle, M. ,  DORAN, Narciso, Ocampo, III

IPC分类号： A61K49/00 ,  A61K49/04 ,  C07C233/05 ,  C07C233/65

CPC分类号： C07C231/12 ,  C07C237/46

摘要： The present invention discloses a new process for producing ioversol (marketed as OPTIRAY3) comprising: (a) reacting 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide with chloroacetyl chloride in a polar aprotic solvent, or combinations thereof, to produce N,N'-bis[2,3-di(2-chloroacetoxy)propyl]-5-(2-chloroacetamido)-2,4,6-triiodoisophthalamide; (b) reacting the product of (a) with sodium hydroxide to produce N,N'-bis(2,3-dihydroxypropyl)-5-(2-chloroacetamido)-2,4,6-triiodoisophthalamide; (c) reacting the product of (b) in water and sodium acetate to produce N,N'-bis(2,3-dihydroxypropyl)-5-glycolamido-2,4,6-triiodoisophthalamide; and (d) reacting the product of (c) with an alkylating agent capable of producing hydroxylhylated product in the presence of a base and water to produce ioversol.

公开(公告)号：EP1250333A1

公开(公告)日：2002-10-23

申请号：EP01942624.6

申请日：2001-01-17

申请人： MALLINCKRODT INC.

发明人： ACHILEFU, Samuel, I. ,  RAJAGOPALAN, Raghavan ,  DORSHOW, Richard, B. ,  BUGAJ, Joseph, E.

IPC分类号： C07D403/08 ,  A61K49/00

CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056 ,  C09B23/0066 ,  C09B23/08

摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel cyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

公开(公告)号：EP1250091A1

公开(公告)日：2002-10-23

申请号：EP01904882.6

申请日：2001-01-17

申请人： Mallinckrodt Inc.

发明人： ACHILEFU, Samuel, I. ,  RAJAGOPALAN, Raghavan ,  DORSHOW, Richard, B. ,  BUGAJ, Joseph, E.

IPC分类号： A61B10/00

CPC分类号： A61K49/0056 ,  A61K49/0032

摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350-1300 nm, the exact range being dependent upon the particular dye. Use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

公开(公告)号：EP1239908A2

公开(公告)日：2002-09-18

申请号：EP00989705.9

申请日：2000-10-26

申请人： MALLINCKRODT INC.

发明人： FRYE, Mark, R.

IPC分类号： A61M16/00 ,  A61M16/14 ,  A61M16/20

CPC分类号： F17C13/04 ,  A61M16/0672 ,  A61M2202/0208 ,  A61M2202/03 ,  F17C9/02 ,  F17C2201/0109 ,  F17C2201/058 ,  F17C2205/0146 ,  F17C2221/011 ,  F17C2223/0123 ,  F17C2223/0153 ,  F17C2223/033 ,  F17C2223/043 ,  F17C2223/046 ,  F17C2223/047 ,  F17C2270/025 ,  A61M2202/0007

摘要： A manifold (206) for a liquid oxygen (LOX) storage/delivery apparatus (200) is provided according to the invention. The manifold (206) for a liquid oxygen (LOX) storage/delivery apparatus (200) includes a gas conduit (205) adapted to communicate with a source of gaseous oxygen, the gas conduit (205) allowing passage of gaseous oxygen and containing a liquid oxygen conduit inside the gas conduit (205), with the liquid oxygen conduit passing through the manifold (206), a gas withdrawal conduit (211) communicating with the gas conduit (205), and a gas vent conduit (214) communicating with the gas conduit (205). The manifold (206) permits independent liquid oxygen passage, independent gaseous oxygen passage, and independent gaseous oxygen venting.

公开(公告)号：EP0762906B1

公开(公告)日：2002-08-28

申请号：EP95919899.5

申请日：1995-05-22

申请人： Mallinckrodt Inc.

发明人： FANTONI, Antonio

IPC分类号： A61M25/01 ,  A61M16/04

CPC分类号： A61M16/0472

摘要： A translaryngeal tracheostomy device having a trocar (11) inserted into an inter-annular space of the trachea, a traction wire (20) inserted into the trocar to move the end of the trochar outside of the oral cavity, a tracheostomy tube (30) with a substantially conical end (40, 55) into which the traction wire is inserted, a fiber optic device (6), and an expansion device (60) fixed to the end of the traction wire to insert the tracheostomy tube in the trachea. A traction guide tool (70) is also disclosed.

公开(公告)号：EP1231857A1

公开(公告)日：2002-08-21

申请号：EP00976831.8

申请日：2000-11-01

申请人： MALLINCKRODT INC.

发明人： CHIN, Rodney

IPC分类号： A61B5/00

CPC分类号： A61B5/6826 ,  A61B5/14552 ,  A61B5/6838 ,  A61B2562/182

摘要： A pulse oximeter sensor having an opaque, metalized layer (16) to shield from ambient light. The metalized layer (16) surrounds the area of the light detector (32). In one embodiment, the sensor has a transparent portion (12), with the opaque, metalized layer (16) covering only the portions around the light detector (32) and other areas, such as a strip extending between the light detector (32) and the emitter (36). In a preferred embodiment, the opaque, metalized layer (16) is a strip which has a widened portion in the area around the light detector (32).

公开(公告)号：EP1230510A1

公开(公告)日：2002-08-14

申请号：EP00976639.5

申请日：2000-10-26

申请人： MALLINCKRODT INC.

发明人： FRYE, Mark, R. ,  TOMA, Lee, S. ,  DAVIS, Richard

IPC分类号： F17C7/02 ,  F17C7/04 ,  F17C6/00

CPC分类号： F17C6/00 ,  F17C7/02 ,  F17C7/04 ,  F17C2201/058 ,  F17C2221/011 ,  F17C2223/0153 ,  F17C2223/047 ,  F17C2225/047

摘要： A high-efficiency liquid oxygen (LOX) storage/delivery system (100) utilizes a portable LOX/delivery apparatus (160) with a portable LOX container (319). A portable-unit LOX transfer connector (304) is connected to the portable LOX container (319) and is connectable to a main source of LOX in a primary reservoir LOX container (226). A portable-unit oxygen gas transfer connector (384) is provided for transferring oxygen gas from the portable LOX container (319) to an oxygen gas delivery device (90) for delivering oxygen gas to a patient. An inter-unit oxygen gas transfer connector (190) also is provided for connecting the portable apparatus (160) to a stationary source of oxygen gas in the primary reservoir container (226), for transferring oxygen gas to the portable apparatus (160). A portable-unit primary relief (315) valve is connected to the portable LOX container (319) for venting oxygen gas out of the portable LOX container (319) when pressure in the portable LOX container (319) reaches a predetermined level. When the inter-unit oxygen gas transfer connector (190) of the portable container (319) is connected to the stationary source of oxygen in the primary reservoir container (226), oxygen gas can be transferred to the oxygen gas delivery device (90) for delivery to the patient from the portable LOX container (319) while oxygen gas is transferred to the portable container (319) from the stationary source of gas in the primary reservoir LOX container (226).

公开(公告)号：EP0946203B1

公开(公告)日：2002-07-24

申请号：EP97924639.4

申请日：1997-05-09

申请人： MALLINCKRODT, INC.

发明人： FUNG, Ella, Y. ,  RAJAGOPALAN, Raghavan

IPC分类号： A61K49/00 ,  G01N31/00 ,  G01N33/48

CPC分类号： A61K49/0021

摘要： This invention provides functional dyes of general formula (1) wherein R?1, R2, and R5¿ may be the same or different and are selected from the group consisting of hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, carboxyl, C1-C10 carboxylalkyl, halogen, nitro, C1-C10 alkoxycarbonyl, mercapto, C1-C10 mercaptoalkyl, C1-C10 alkylthio, sulfonate, and -(CH2)m-N(R?6)(R7¿) wherein R?6 and R7¿ are independently hydrogen or C¿1?-C10 alkyl, C1-C10 acyl, and R?6 and R7¿ are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with -O-, -NR8, or -S-; R?3 and R4¿ may be the same or different and are selected from the group consisting of C¿1?-C10 alkyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkyl sulfonate, mercapto alkyl and -(CH2)mN(R?6)(R7); W1 and W2¿ may be the same or different and are selected from the group consisting of -S-, -O-, -Se-, -Te-, -NR8 and C(R9)(R10); and m is about 0-10; R8 is hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxy, C1-C10 mercaptoalkyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkoxycarbonyl, C1-C10 alkylthio, and -(CH2)m-N(R?6)(R7); R9 and R10¿ are independently hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 carboxyalkyl, C1-C10 alkoxycarbonyl, and -(CH2)m-N(R?6)(R7¿); and A is selected from the group consisting of -(CH¿2?)m, -C(R?9)(R10¿), -(CH¿2?)m-N(R?6)(R7¿), -O-, -S-, or -NR8.

公开(公告)号：EP1208852A1

公开(公告)日：2002-05-29

申请号：EP00204183.8

申请日：2000-11-24

申请人： Mallinckrodt Inc.

发明人： Reubi, Jean Claude

IPC分类号： A61K51/08 ,  A61P35/00

CPC分类号： A61K51/08

摘要： The present invention relates to the use of compounds that bind the neuropeptide Y 1 (NPY 1 ) receptor for the preparation of a pharmaceutical composition for the diagnosis or treatment of tumors expressing NPY 1 receptors, in particular breast cancer, ovarium cancer and glioblastoma. The invention also relates to the pharmaceutical compositions that contain such compounds.

摘要翻译： 本发明涉及结合神经肽Y1（NPY1）受体的化合物在制备用于诊断或治疗表达NPY1受体，特别是乳腺癌，卵巢癌和成胶质细胞瘤的肿瘤的药物组合物中的用途。 本发明还涉及含有这些化合物的药物组合物。

公开(公告)号：EP0886634B1

公开(公告)日：2002-04-24

申请号：EP97903077.2

申请日：1997-01-27

申请人： Mallinckrodt Inc.

发明人： DUNN, Thomas, Jeffrey ,  WHITE, David, H. ,  KNELLER, Mills, Thomas ,  JONES, Michelle, M. ,  DORAN, Narcisco, Ocampo, III ,  BAILEY, Allan, R.

IPC分类号： C07C233/05 ,  C07C233/65 ,  A61K31/165 ,  A61K49/00 ,  C07C237/46 ,  C07C231/12

CPC分类号： C07C237/46

摘要： The present invention discloses a new process for producing ioversol (marketed as OPTIRAY3) comprising: (a) reacting 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisopthalamide with chloroacetyl chloride in a polar aprotic solvent or combinations thereof to produce N,N'-bis[2,3-di(2-chloroacetoxy)propyl]-5-(2-chloroacetamido)-2,4,6-triiodoisopthalamide; (b) reacting the product of (a) with a base to produce N,N'-bis(2,3-dihydroxypropyl)-5-(2-chloroacetamido)-2,4,6-triiodoisopthalamide; (c) reacting the product of (b) with an alkylating agent capable of producing a hydroxyethylated product in the presence of a base and water to produce N,N'-bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl) (2-chloroacetamido)]-2,4,6-triiodoisopthalamide; and (d) reacting the product of (c) in water and acetate ions to produce ioversol.