HYDROXY-SPHINGOMYELIN 22:1 AS BIOMARKER FOR HEALTHY AGEING
    122.
    发明公开
    HYDROXY-SPHINGOMYELIN 22:1 AS BIOMARKER FOR HEALTHY AGEING 有权
    羟脯氨酸22:1 ALS BIOMARKERFÜRGESUNDES ALTERN

    公开(公告)号:EP2828668A1

    公开(公告)日:2015-01-28

    申请号:EP13709175.7

    申请日:2013-03-05

    申请人: Nestec S.A.

    IPC分类号: G01N33/68 G01N33/92

    摘要: Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using hydroxy- sphingomyelin SM-OH-22:1as biomarker.

    摘要翻译: 使用基于NMR / MS的代谢组学和靶向脂质组学方法,发明人已经探索了老年人和年轻成年人的老龄化和寿命的代谢表型。 本发明人已经鉴定出降低发展与衰老有关的慢性炎症性疾病的风险的生物标志物,并提出了一种诊断生活方式的方法,该方法允许使用羟基鞘磷脂SM-OH-22:1作为生物标志物延迟和/或避免老化相关的慢性炎症性疾病。

    ORGANIC COMPOUNDS
    123.
    发明公开
    ORGANIC COMPOUNDS 有权
    氮杂 - 硫杂benzazulene衍生物及其药物用途dered

    公开(公告)号:EP1989209A2

    公开(公告)日:2008-11-12

    申请号:EP07722883.1

    申请日:2007-02-21

    申请人: NOVARTIS AG

    IPC分类号: C07D495/04

    CPC分类号: C07D495/04

    摘要: The present invention relates to novel aza-thia-benzoazulene derivatives of formula I as defined in the claims, their preparation, the use of these novel compounds for the preparation of pharmaceutical compositions, the use of these novel compounds and compositions for managing arthritis and arthritis-related conditions as well as in the treatment of pain in animals and humans. More particularly, the present invention relates to pharmaceutical, preferably veterinary compositions and methods for reducing inflammation and pain associated with acute inflammation of body parts, particularly joints, due to injury or due to arthritic conditions or other disease conditions.