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431 条记录 (耗时 0.022 秒)

    Cemented carbide articles and master alloy composition
    145.
    发明公开
    Cemented carbide articles and master alloy composition 失效
    Zementierer Karbideartikel und Vorlegierungszusammensetzung

    公开(公告)号：EP0763605A2

    公开(公告)日：1997-03-19

    申请号：EP96305884.7

    申请日：1996-08-12

    申请人： NANODYNE INCORPORATED ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

    发明人： McCandish, Larry E. ,  Sadangi, Rajendra K.

    IPC分类号： C22C29/06 ,  C22C29/08

    CPC分类号： C22C29/08 ,  B22F9/026 ,  B22F2003/1032 ,  C22C1/051 ,  C22C29/067

    摘要： A low melting point alloy is used to sinter metal carbide particles. The alloy is a eutectic-like alloy formed from a binding metal such as iron, cobalt or nickel, in combination with vanadium and chromium. The alloy is preferably formed by forming two separate alloys and blending these together. The first alloy is formed by spray drying together a solution of a binding metal salt such as a cobalt salt with a solution of a chromium salt. The formed particles are then carburized to form a cobalt-chromium-carbon alloy. A separate vanadium alloy is formed in the same manner. The two are combined to establish the amount of chromium and vanadium desired, and this, in turn, is used to sinter metal carbide parts. This permits sintering of the metal carbide parts at temperatures less than 1250° C and in turn significantly inhibits grain grown without a significant decrease in toughness. It is particularly adapted to form carbide products wherein the carbide grain size is as low as 120 nanometers.

    摘要翻译： 使用低熔点合金烧结金属碳化物颗粒。 该合金是由诸如铁，钴或镍的结合金属与钒和铬组合形成的共晶合金。 合金优选通过形成两个单独的合金并将它们混合在一起而形成。 通过将结合金属盐如钴盐的溶液与铬盐溶液一起喷雾干燥而形成第一合金。 然后将形成的颗粒渗碳以形成钴 - 铬 - 碳合金。 以相同的方式形成单独的钒合金。 两者结合以确定所需的铬和钒的量，并且这又用于烧结金属碳化物部件。 这允许金属碳化物部件在小于1250℃的温度下烧结，反过来又显着抑制晶粒生长而不显着降低韧性。 它特别适用于碳化物产品，其中碳化物晶粒尺寸低至120纳米。

    COHERENT, FLEXIBLE, COATED-BORE HOLLOW-FIBER WAVEGUIDE, AND METHOD OF MAKING SAME
    146.
    发明公开
    COHERENT, FLEXIBLE, COATED-BORE HOLLOW-FIBER WAVEGUIDE, AND METHOD OF MAKING SAME 失效
    KOHERENTER，灵活WELLEMLEITER中空纤维与覆膜的孔和制造方法包括

    公开(公告)号：EP0744034A1

    公开(公告)日：1996-11-27

    申请号：EP95906182.0

    申请日：1995-01-10

    申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

    发明人： HARRINGTON, James, A. ,  ABEL, Todd, C. ,  HIRSCH, Jeffrey

    IPC分类号： G02B6

    CPC分类号： G02B6/032 ,  G02B6/102

    摘要： A rugged flexible hollow-fiber waveguide (1) that permits preservation of good transverse spatial coherence of input infrared laser radiation and that transmits substantial power of such radiation, with low attenuation. The present invention preferably comprises a small-diameter thin-wall silica-glass tube (3); a protective coating (2) on the outer surface of the tube; a sufficient reflective layer (4) on the inner surface of the tube (3); and a thickness, optimal for the wavelength(s) of interest, of dielectric on the exposed surface of the reflective layer (4). The fiber (1) is manufactured with processes that maintain the smoothness of the bore.

    RNA PACKAGING SYSTEM
    147.
    发明公开
    RNA PACKAGING SYSTEM 失效
    RNA包装系统。

    公开(公告)号：EP0683821A1

    公开(公告)日：1995-11-29

    申请号：EP93925119.0

    申请日：1993-10-28

    申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

    发明人： WILSON, Thomas M. A. The Coach House ,  HWANG-LEE, Duk-Ju

    IPC分类号： C12N15 ,  C07K14 ,  C12N1 ,  C12N7 ,  C12P21 ,  C12R1

    CPC分类号： C07K14/005 ,  C12N7/00 ,  C12N15/10 ,  C12N15/8201 ,  C12N15/8206 ,  C12N2770/00022 ,  Y10S435/81

    摘要： The present invention relates to an in vivo system for expression and packaging of recombinant RNA into pseudovirus particles. The invention is based on the discovery that plant viral coat proteins (CPs) may be efficiently expressed in E. coli, and that these recombinant coat proteins will function to assemble in vivo and package recombinant chimeric RNA, containing an operatively linked origin-of-assembly (OAS) sequence, to form mature viral particles containing a foreign RNA. The present invention thus provides for packaging of RNA into a ribonuclease-resistant form that is easily purified and stored, and which overcomes the prior art problems associated with degradation of RNA by ribonucleases. Significantly, the method of the invention is RNA sequence- and length-independent. The components of the invention include a source in the bacterial host of viral coat proteins, and a source in the bacterial host to direct the transcription of a DNA molecule comprising an OAS-encoding DNA and a foreign DNA, which DNA molecule can be transcribed in the host cell to produce an RNA molecule comprising an OAS operatively linked to an RNA of interest. The CPs and OAS are from a plant virus having a rod-shaped helical particle and a single-stranded RNA genome, most preferably tobacco mosaic virus.

    Transdermal estrogen/progestin dosage unit, and fertility control kit comprising said dosage unit.
    149.
    发明公开
    Transdermal estrogen/progestin dosage unit, and fertility control kit comprising said dosage unit. 失效
    蜕皮激素/孕激素 - 爱因斯顿，系统和Verfahren。

    公开(公告)号：EP0275716A1

    公开(公告)日：1988-07-27

    申请号：EP87311508.3

    申请日：1987-12-29

    申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

    发明人： Chien, Yie W., ,  Chien, Te-Yen, ,  Huang, Yih-Chain,

    IPC分类号： A61L15/16 ,  A61K31/565

    CPC分类号： A61K9/7061 ,  A61K9/7092 ,  A61K31/565 ,  A61K31/567

    摘要： Transdermal estrogen progestin absorption dosage units have been developed which comprise a backing layer, an adjoining polymer layer is an adhesive layer in which at least minimum effective dose of an estrogen is dissolved or microdispersed. Adhered to the polymer layer is an adhesive layer in which is dissolved and or microdispersed at least minimum doses of progestin. Presently preferred is use of the natural estrogen, 17-beta-estradiol, or ethinyl estradiol or combinations thereof and of the progestin, norethindrone or norgestimate or combinations thereof. The units have biologically acceptable adhesive and polymer layers. The adhesive layer can have dispersed one or more skin permeation enhancing agents. A separating layer can optionally be used in making the dosage units, which separate space the adhesive and polymer layers, which permits estrogen transmission from the polymer layer during treatment. Dosage units are provided which transdermally deliver at least minimum daily doses of the estrogen and progestin for multiple days, such as for one week. The invention also provides a process of fertility control and estrogen replacement therapy using the novel dosage units. Also. the invention provides a fertility control system for fertility control using the novel dosage units.

    摘要翻译： 已经开发了经皮雌激素/孕激素吸收剂量单位，其包含背衬层，相邻的聚合物层是其中至少最小有效剂量的雌激素溶解或微分散的粘合剂层。 粘附到聚合物层上的粘合剂层是其中溶解和/或微分散至少最小剂量的孕激素的粘合剂层。 目前优选使用天然雌激素，17-β-雌二醇或乙炔雌二醇或其组合以及孕激素，炔诺酮或诺孕酯或其组合。 这些单元具有生物可接受的粘合剂和聚合物层。 粘合剂层可以具有分散的一种或多种皮肤渗透增强剂。 分离层可以可选地用于制备剂量单位，其分离空间粘合剂和聚合物层，其允许在治疗期间从聚合物层传递雌激素。 提供剂量单位，其经皮递送至少最小日剂量的雌激素和孕激素多天，例如一周。 本发明还提供使用新型剂量单位的生育调节和雌激素替代疗法的方法。 此外，本发明提供了使用新型剂量单位的育性控制的育性控制系统。