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公开(公告)号：EP1974738A3
公开(公告)日：2008-12-17
申请号：EP08157330.5
申请日：2001-02-26
IPC分类号： C12Q1/68 , A61K38/00 , A61K31/70 , A61K39/395 , A01K67/027 , C12N15/00 , A61P27/06 , C12N9/00 , C07K14/47
CPC分类号： G01N33/5091 , A61K38/00 , C07K14/47 , C12N9/12 , C12Q1/485 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5041 , G01N33/5044 , G01N33/6893 , G01N2800/168
摘要： This invention provides methods and compositions for diagnosing and treating glaucoma based on determining the level of a Frizzle Related Protein (FRP), a component of the wingless (Wnt) signaling pathway. The method can include the detection of a genetic lesion like polymorphic allele (e.g. FRP promoter, ...) for diagnosing glaucoma. This invention also discloses the use of transgenic animals for the study of glaucoma (screening for therapeutics, animal disease model, ...).
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公开(公告)号：EP1996251A2
公开(公告)日：2008-12-03
申请号：EP07717344.1
申请日：2007-01-22
申请人： Alcon, Inc.
发明人： GAO, Shawn X. , DOMASH, David M.
IPC分类号： A61M1/00
CPC分类号： A61M1/0058 , A61F9/00736 , A61M1/0001 , A61M1/0027 , A61M1/0031 , A61M1/0035 , A61M1/0076 , A61M2205/12 , A61M2205/123 , A61M2205/3379 , A61M2205/3389
摘要： A surgical cassette having an aspiration chamber with a bubble separating structure. The bubble separating structure facilitates accurate, reliable measurement of the fluid level in the chamber.
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公开(公告)号：EP1996249A2
公开(公告)日：2008-12-03
申请号：EP07710250.7
申请日：2007-01-22
申请人： Alcon, Inc.
发明人： DOMASH, David, M.
IPC分类号： A61M1/00
CPC分类号： A61M1/0049 , A61M1/0001 , A61M2205/12 , A61M2205/123 , A61M2205/3389
摘要： A surgical cassette having a chamber for fluidly coupling to a source of vacuum in a surgical console and a bubble breaking structure disposed within the chamber. The cassette protects the source of vacuum from liquid.
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公开(公告)号：EP1867349B1
公开(公告)日：2008-11-19
申请号：EP07109823.0
申请日：2007-06-07
申请人： Alcon, Inc.
发明人： Williams, David , Bowman, Michael
IPC分类号： A61M1/00
CPC分类号： A61M1/0058 , Y10T292/20 , Y10T292/225
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公开(公告)号：EP1990032A1
公开(公告)日：2008-11-12
申请号：EP08156019.5
申请日：2008-05-09
申请人： Alcon, Inc.
IPC分类号： A61F9/007
CPC分类号： A61F9/00745 , A61B2017/320098 , A61M2205/3344 , B06B1/0261 , B06B3/00
摘要： A method employing a handpiece having at least one set of piezoelectric elements polarized to produce longitudinal motion when excited at the relevant resonant frequency. The piezoelectric crystals are connected to an ultrasonic horn to which a cutting tip is attached. The horn and/or the cutting tip contains a plurality of diagonal slits or grooves. The slits or grooves produce optimized torsional movement in the cutting tip when the piezoelectric crystals are excited at a second resonant frequency. When in torsional mode, material may clog the cutting tip. The present method includes the step of providing a pulse of longitudinal movement of the tip when clogging is detected.
摘要翻译： 一种采用手持件的方法，所述手持件具有至少一组压电元件，所述至少一组压电元件在相关谐振频率下被激励时产生纵向运动。 压电晶体连接到超声变幅杆，切割尖端连接到超声变幅杆。 喇叭和/或切割尖端包含多个对角狭缝或凹槽。 当压电晶体以第二谐振频率激励时，狭缝或凹槽在切割尖端产生优化的扭转运动。 在扭转模式下，材料可能会堵塞切割尖端。 本方法包括当检测到堵塞时提供尖端纵向移动的脉冲的步骤。
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166.发明公开
公开(公告)号：EP1938846A3
公开(公告)日：2008-11-05
申请号：EP08002333.6
申请日：2003-12-11
申请人： Alcon, Inc.
CPC分类号： A61L12/08 , A61L12/142 , A61L12/145 , C11D3/0078 , C11D3/3719 , C11D3/3773 , Y10S514/839 , Y10T428/31725
摘要： The use of NIPAM polymers to prevent or reduce the formation of protein deposits on the surfaces of medical devices is described. The invention is particularly directed to reduction of the adsorption of proteins on surfaces of contact lenses and other medical prosthetics.
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公开(公告)号：EP1933750A4
公开(公告)日：2008-11-05
申请号：EP06815351
申请日：2006-09-25
申请人： ALCON INC
CPC分类号： A61F9/00736 , A61F9/00763 , B21D22/14 , B21D41/045 , B21G1/08 , B21J5/063 , B21K21/14 , B23K11/0046 , B23K11/02 , B23K11/16 , B23K33/006 , B23K2201/06
摘要： Microsurgical probes having a distal tip with a flat outer surface and a flat inner surface, and methods of forming such probes, are disclosed.
摘要翻译： 公开了具有具有平坦外表面和平坦内表面的远侧尖端的显微手术探针，以及形成这种探针的方法。
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公开(公告)号：EP1981416A2
公开(公告)日：2008-10-22
申请号：EP07763558.9
申请日：2007-02-01
申请人： Alcon, Inc.
发明人： KIRCHHEVEL, G. Lamar
IPC分类号： A61B17/32
CPC分类号： A61F9/00763 , A61B2017/00544 , A61B2017/2918 , A61B2017/305 , A61B2090/034
摘要： A microsurgical instrument including a cutting member and a base with an actuating mechanism that provides more efficient cutting of tissue.
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公开(公告)号：EP1974738A2
公开(公告)日：2008-10-01
申请号：EP08157330.5
申请日：2001-02-26
IPC分类号： A61K38/00 , A61K39/395 , A01K67/027 , C12N15/00 , A61P27/06 , C12N9/00 , C07K14/47 , C12Q1/68
CPC分类号： G01N33/5091 , A61K38/00 , C07K14/47 , C12N9/12 , C12Q1/485 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5041 , G01N33/5044 , G01N33/6893 , G01N2800/168
摘要： This invention provides methods and compositions for diagnosing and treating glaucoma based on determining the level of a Frizzle Related Protein (FRP), a component of the wingless (Wnt) signaling pathway. The method can include the detection of a genetic lesion like polymorphic allele (e.g. FRP promoter, ...) for diagnosing glaucoma. This invention also discloses the use of transgenic animals for the study of glaucoma (screening for therapeutics, animal disease model, ...).
摘要翻译： 本发明提供了用于诊断和治疗青光眼的方法和组合物，所述方法和组合物基于确定无翅（Wnt）信号通路的组分的卷曲相关蛋白（FRP）的水平。 该方法可以包括用于诊断青光眼的遗传病变如多态等位基因（例如FRP启动子，...）的检测。 本发明还公开了使用转基因动物研究青光眼（筛选治疗学，动物疾病模型，...）。
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公开(公告)号：EP1968470A2
公开(公告)日：2008-09-17
申请号：EP06849209.9
申请日：2006-12-11
申请人： Alcon, Inc.
CPC分类号： A61F9/00736 , A61B18/14
摘要： An apparatus and method for the dissociation of soft proteinaceous tissue using pulsed rapid variable direction energy field flow fractionization is disclosed. The pulsed rapid disruptive energy field is created by the use of a probe which surrounds the soft proteinaceous tissue to be removed. Once the adhesive mechanism between tissue constituents has been compromised, fluidic techniques are used to remove the dissociated tissue.
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