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210 条记录 (耗时 0.026 秒)

    1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS
    161.
    发明公开
    1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权
    1H呋喃并[3,2-C]吡唑化合物，其适合用作激酶抑制剂的

    公开(公告)号：EP2051981A1

    公开(公告)日：2009-04-29

    申请号：EP07729539.2

    申请日：2007-05-25

    申请人： NERVIANO MEDICAL SCIENCES S.r.l.

    发明人： FANCELLI, Daniele ,  PULICI, Maurizio ,  MOLL, Jurgen ,  BANDIERA, Tiziano

    IPC分类号： C07D491/04 ,  A61K31/4162 ,  A61P35/00

    CPC分类号： C07D491/048

    摘要： Furo[3,2-c]pyrazole derivatives of formula (I) as defined in the description, and pharmaceutically acceptable salts thereof, wherein A is an aryl or heteroaryl ring, - NHZR5 is at the ortho position to the CONH linker; - R1 and R2 are the same or different and, independently from each other, represent a hydrogen atom, or an organic residue; R3 is a hydrogen or halogen atom or an organic group; R4 is a hydrogen or halogen atom or an organic group; Z is direct bond, >C=O, or -C(=O)NH-; - R5 is hydrogen or an optionally substituted organic group or isomers, tautomers, carriers, metabolites, prodrugs, and pharmaceutically acceptable salts thereof. A process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, in particular Aurora kinases activity or IGF-1R activity, like cancer.

    1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS
    163.
    发明公开
    1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权
    -1H-噻吩并[2,3-C] -PYRAZOLVERBINDUNGEN适用作为激酶抑制剂的

    公开(公告)号：EP1904503A1

    公开(公告)日：2008-04-02

    申请号：EP06764123.3

    申请日：2006-07-10

    申请人： NERVIANO MEDICAL SCIENCES S.r.l.

    发明人： MOLL, Juergen ,  FANCELLI, Daniele ,  BANDIERA, Tiziano ,  QUARTIERI, Francesca ,  PULICI, Maurizio

    IPC分类号： C07D495/04 ,  A61K31/4162 ,  A61P35/00

    CPC分类号： C07D495/04

    摘要： There are provided thieno[2,3-c]pyrazole derivatives of formula (I), wherein A is an aryl or heteroaryl ring, on which the substituent -NHZR5 is at the ortho position to the CONH linker; R1 and R2 are the same or different and, independently from each other, represent a hydrogen atom or an organic group; R4 is a hydrogen or halogen atom or an organic group; Z is direct bond, >C=O, or -C(=O)NH-; R5 is hydrogen or an organic group; or isomers, tautomers, carriers, metabolites, prodrugs, and pharmaceutically acceptable salts thereof. A process for their preparation and pharmaceutical compositions comprising them are also disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.