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公开(公告)号：EP2539439A1
公开(公告)日：2013-01-02
申请号：EP11747958.4
申请日：2011-02-23
申请人： ABT Holding Company
CPC分类号： A61K35/545 , G01N33/5008
摘要： The invention provides methods for treating pathological conditions that can be improved by providing angiogenesis. The invention is generally directed to provide angiogenesis by administering cells that express and/or secrete one or more pro-angiogenic factors. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to express and/or secrete one or more pro-angiogenic factors. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired levels of expression and/or secretion of one or more pro-angiogenic factors.
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公开(公告)号：EP2539436A1
公开(公告)日：2013-01-02
申请号：EP11748062.4
申请日：2011-02-24
IPC分类号： C12N5/00
CPC分类号： C12N5/0607 , A61K2035/122 , A61K2035/124
摘要： The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by administering cells that modulate macrophage activation. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to modulate macrophage activation. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency to modulate macrophage activation.
摘要翻译： 本发明提供了用于治疗与不期望的炎症成分相关的病理状态的方法。 本发明总体上涉及通过施用调节巨噬细胞活化的细胞来减轻炎症。 本发明还涉及筛选调节细胞调节巨噬细胞活化能力的药物的药物发现方法。 本发明还涉及可用于提供给受试者施用细胞的细胞库，所述库包含具有调节巨噬细胞活化所需效力的细胞。
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公开(公告)号：EP2539436B1
公开(公告)日：2021-09-22
申请号：EP11748062.4
申请日：2011-02-24
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公开(公告)号：EP3405566A1
公开(公告)日：2018-11-28
申请号：EP16886758.8
申请日：2016-02-12
发明人： LUTTUN, Aernout , DEANS, Robert, J.
IPC分类号： C12N5/07
CPC分类号： A61K35/28 , A01K2207/12 , A01K2227/105 , A01K2267/03 , A61K35/12 , C12N5/0607
摘要： The present invention provides a method for treating wounds by applying cells as described in this application. In one aspect the method provides treatment for cutaneous wounds. In general embodiments the cells are delivered to the wound without being attached to a functionalized substrate in the delivery vehicle.
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公开(公告)号：EP2938345B1
公开(公告)日：2018-08-22
申请号：EP13864916.5
申请日：2013-12-23
申请人： ABT Holding Company
发明人： ROBARGE, Mike , HARRINGTON, John , GERRISH, David , MECOM, John
IPC分类号： A61K31/55 , C07D223/32 , C07D401/04 , C07D417/04 , C07D491/048 , C07D491/052
CPC分类号： C07D223/32 , C07D401/04 , C07D417/04 , C07D491/048 , C07D491/052
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are benzazepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).
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17.发明授权Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof 有权多波坦特成体干细胞，原料为他们获取和保留，分化技术及其使用方法，以及细胞程序从中派生
公开(公告)号：EP1491093B1
公开(公告)日：2013-07-31
申请号：EP04023157.3
申请日：2002-02-14
IPC分类号： A01N63/00
CPC分类号： A61K39/001 , A01K67/0271 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/106 , A61K35/12 , A61K48/00 , C12N5/0607 , C12N5/0619 , C12N5/0622 , C12N5/067 , C12N15/873 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/12 , C12N2501/135 , C12N2501/235 , C12N2501/237 , C12N2502/08 , C12N2502/30 , C12N2503/00 , C12N2506/03 , C12N2517/02
摘要： An isolated multipotent adult stem cell (MASC), which has the capacity to be induced to differentiate to form at least one differentiated cell type of mesodermal, ectodermal or endodermal origin, is new. Independent claims are also included for: (1) creating (M1) a normal non-human animal; (2) compositions comprising: (a) a population of MASC and a medium, where the culture medium expands the MASC; or (b) a population of fully or partially purified MASC progeny; (3) isolating (M2) and propagating the MASC; (4) an expanded MASC population obtained by (M2); (5) differentiating (M3) MASC ex vivo or in vivo; (6) differentiated cells obtained by (M3); (7) a therapeutic composition comprising MASC and a pharmaceutical carrier, where the MASC are present in to produce bone marrow, blood, spleen, liver, lung, intestinal tract, eye, brain, immune system, bone, connective tissue, muscle, heart, blood vessels, pancreas, central nervous system, kidney, bladder, skin, epithelial appendages, breast-mammary gland, fat or mucosal surface (e.g. oral, esophageal, vaginal or anal) tissues; (8) restoring (M4) organ tissue or cellular function to a patient; (9) inhibiting (M5) the rejection of a heterologous MASC transplanted into a patient; (10) generating (M6) blood or individual blood components ex vivo; (11) drug discovery; (12) identifying (M7) the components of a differentiation pathway; (13) comparing (M8) differentiation in vitro with differentiation in vivo by comparing the results obtained in (M7); (14) identifying (M9) the molecular components of disease or injury; (15) generating (M10) products (which have therapeutic, diagnostic or research utility) in vitro; (16) inducing (M11) in a mammal, tolerance to an antigen administered to the mammal; (17) removing (M12) toxins from the blood of a patient; (18) delivering (M13) therapeutic products to a patient; and (19) testing (M14) the toxicity of a drug. ACTIVITY : Cytostatic; Cardiant; Cardiovascular; Hepatotropic; Hemostatic; Antidiabetic; Virucide; Anti-inflammatory; Vasotropic; Neuroprotective; Antianemic; Cerebroprotective; Immunosuppressant; Antibacterial. No biological data given. MECHANISM OF ACTION : Cell Replacement Therapy.
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公开(公告)号：EP2456853A1
公开(公告)日：2012-05-30
申请号：EP10802840.8
申请日：2010-07-21
申请人： ABT Holding Company
IPC分类号： C12N3/00
摘要： The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in vascular endothelial cells. Downregulating expression of cellular adhesion molecules reduces leukocyte adhesion to the endothelial cells such that extravasation is reduced. The end result is a reduction of inflammation. The cells are non-embryonic non-germ cells that have pluripotent characteristics. These may include expression of pluripotential markers and broad differentiation potential.
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公开(公告)号：EP3405566B1
公开(公告)日：2023-10-18
申请号：EP16886758.8
申请日：2016-02-12
发明人： LUTTUN, Aernout , DEANS, Robert, J.
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公开(公告)号：EP2568991B1
公开(公告)日：2018-03-21
申请号：EP11781272.7
申请日：2011-05-12
申请人： ABT Holding Company
发明人： MAYS, Robert, W.
IPC分类号： C12N5/074 , G01N33/483 , A61K35/28
CPC分类号： A61K35/28 , A61K35/545 , C12N5/0607 , G01N33/5047 , G01N33/505 , G01N33/6893 , G01N2333/5406 , G01N2333/5412 , G01N2333/5428 , G01N2333/545 , G01N2333/70514 , G01N2333/70517 , G01N2500/00 , G01N2800/24 , G01N2800/52
摘要： The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by administering cells that have one or more of the following effects in an injured subject: interact with splenocytes, preserve splenic mass, increase proliferation of CD4+ and CD8+ T-cells, increase IL-4 and IL-10, decrease IL-6 and IL-1β, and increase M2:M1 macrophage ratio at the site of injury. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to have these effects. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency for achieving these effects.
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