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11.发明授权
公开(公告)号：EP1774001B1
公开(公告)日：2012-08-22
申请号：EP05762794.5
申请日：2005-06-22
发明人： NEGROUK, Valentin , WONG, Hing, C. , TAYLOR, Dean , HAN, Kai-ping
IPC分类号： A61K38/36 , C07K14/745
CPC分类号： C07K14/70596 , C12N15/8257
摘要： The instant invention provides plant expression vectors comprising a first promoter operable in a plant, an expressible nucleic acid sequence encoding a mammalian tissue factor protein or functional fragment thereof, wherein the nucleic acid sequence is peparatively associated with the promoter, and a termination sequence operatively associated with the nucleic acid sequence. The invention further provides methods of making the tissue factor protein, or functional fragment thereof, using the claimed vectors and plants, and methods of treating or preventing blood loss, of promoting wound healing, promoting angiogenesis, or promoting vascular remodeling in a subject by administering the tissue factor proteins to a subject.
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公开(公告)号：EP1691661A2
公开(公告)日：2006-08-23
申请号：EP04818691.0
申请日：2004-11-10
IPC分类号： A61B20060101
CPC分类号： A61K51/1027 , A61K47/48261 , A61K47/48269 , A61K47/48276 , A61K47/48353 , A61K47/6415 , A61K47/642 , A61K47/6425 , A61K47/665 , B82Y5/00 , C07K14/55 , C07K14/7051 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/32 , G01N33/57484 , G01N33/57492 , G01N33/6875 , G01N2333/7051 , G01N2333/70539
摘要： Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.
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公开(公告)号：EP0877760B1
公开(公告)日：2004-09-15
申请号：EP97905709.8
申请日：1997-01-30
CPC分类号： C07K14/70539 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/53 , A61K2039/6043 , A61K2039/622 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to novel complexes of major histocompatibility complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to loaded MHC complexes that include at least one MHC molecule with a peptide-binding groove and a presenting peptide non-covalently linked to the MHC protein. In another aspect, the invention features single chain MHC class II peptide fusion complexes with a presenting peptide covalently linked to the peptide binding grove of the complex. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.
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公开(公告)号：EP3327040A1
公开(公告)日：2018-05-30
申请号：EP17200359.2
申请日：2011-09-21
发明人： WONG, Hing C. , RHODE, Peter , LIU, Bai , ZHU, Xiaoyun , HAN, Kai-ping
IPC分类号： C07K19/00 , C07K14/54 , C07K14/075 , C12N15/62 , A61K38/17 , A61P35/00 , C12N1/00 , C12N5/00 , A61K38/00 , C07K14/715 , A61K38/20 , C07K16/18 , A61K45/06 , C07K16/28 , C12P21/00 , C12N15/09
CPC分类号： C07K14/7155 , A61K38/00 , A61K38/1793 , A61K38/2086 , A61K39/3955 , A61K45/06 , C07K14/5443 , C07K16/18 , C07K16/2887 , C07K2317/622 , C07K2317/732 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C12N15/09 , C12N15/62 , C12P21/00 , A61K2300/00
摘要： The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
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公开(公告)号：EP2411545B1
公开(公告)日：2017-03-08
申请号：EP10756833.9
申请日：2010-03-25
IPC分类号： C12Q1/70
CPC分类号： C07K14/70503 , C07K14/705 , C07K14/7051 , G01N33/56988
摘要： The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQL (SEQ ID NO: 1)).
摘要翻译： 本发明提供了具有与HIV蛋白质vpr（AIIRILQQL（SEQ ID NO：1））的AL9表位结合的一个或多个氨基酸取代的TCR。
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16.发明公开MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME 有权多聚IL-15可溶性融合分子和方法的生产和使用
公开(公告)号：EP2918607A1
公开(公告)日：2015-09-16
申请号：EP15162957.3
申请日：2011-09-21
发明人： Wong, Hing, C. , Rhode, Peter , Liu, Bai , Zhu, Xiaoyun , Han, Kai-ping
IPC分类号： C07K19/00 , C07K14/54 , C07K14/075 , C12N15/62 , A61K38/17 , A61P35/00 , C12N1/00 , C12N5/00 , A61K38/00 , C07K14/715 , A61K38/20 , C07K16/18
CPC分类号： C07K14/7155 , A61K38/00 , A61K38/1793 , A61K38/2086 , A61K39/3955 , A61K45/06 , C07K14/5443 , C07K16/18 , C07K16/2887 , C07K2317/622 , C07K2317/732 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C12N15/09 , C12N15/62 , C12P21/00 , A61K2300/00
摘要： The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
摘要翻译： 本发明提供了具有至少两个可溶性融合蛋白可溶性融合蛋白复合物。 第一融合蛋白是共价连接于在白细胞介素-15（IL-15）多肽或其功能性片段的生物学活性多肽。 所述第二融合蛋白是共价连接到可溶性白介素15受体α（IL-15R±）多肽或其功能片段的第二生物学活性多肽。 在本发明中，一个或两个所述第一和第二融合蛋白的的复合物包括进一步与免疫球蛋白Fc结构域或其功能片段; 并且第一融合蛋白结合至所述第二融合蛋白的可溶性IL-15R±域，以形成一种可溶性融合蛋白复合物。 本发明进一步提供用于制造和使用本发明的复合物的方法。
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公开(公告)号：EP2388266A3
公开(公告)日：2012-06-13
申请号：EP11178091.2
申请日：2008-05-09
发明人： Wong, Hing C. , Rhode, Peter , Zhu, Xiaoyun , Han, Kai-ping
IPC分类号： C07K14/00 , C12N15/62 , C07K14/54 , C07K14/715
CPC分类号： C07K14/5443 , A61K38/00 , A61K38/1774 , A61K38/1793 , A61K38/2086 , C07K14/7051 , C07K14/7155 , C07K16/18 , C07K16/28 , C07K2319/00 , C07K2319/31 , C07K2319/33 , C07K2319/74 , C07K2319/75 , C12N15/09 , C12N15/62 , C12P21/00 , G01N33/56977
摘要： The instant invention provides soluble fusion protein complexes and IL- 15 variants that have therapeutic and diagnostic use, and methods for making thesuch proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL- 15 variants of the invention.
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公开(公告)号：EP2160401A1
公开(公告)日：2010-03-10
申请号：EP08743432.0
申请日：2008-05-09
发明人： WONG, Hing, C. , RHODE, Peter , ZHU, Xiaoyun , HAN, Kai-ping
IPC分类号： C07K14/00
CPC分类号： C07K14/5443 , A61K38/00 , A61K38/1774 , A61K38/1793 , A61K38/2086 , C07K14/7051 , C07K14/7155 , C07K16/18 , C07K16/28 , C07K2319/00 , C07K2319/31 , C07K2319/33 , C07K2319/74 , C07K2319/75 , C12N15/09 , C12N15/62 , C12P21/00 , G01N33/56977
摘要： The instant invention provides soluble fusion protein complexes and IL- 15 variants that have therapeutic and diagnostic use, and methods for making thesuch proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL- 15 variants of the invention.
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公开(公告)号：EP1774001A2
公开(公告)日：2007-04-18
申请号：EP05762794.5
申请日：2005-06-22
发明人： NEGROUK, Valentin , WONG, Hing, C. , TAYLOR, Dean , HAN, Kai-ping
IPC分类号： C12N15/82 , C07K14/745 , A61K38/36 , A01H5/00
CPC分类号： C07K14/70596 , C12N15/8257
摘要： The instant invention provides plant expression vectors comprising a first promoter operable in a plant, an expressible nucleic acid sequence encoding a mammalian tissue factor protein or functional fragment thereof, wherein the nucleic acid sequence is peparatively associated with the promoter, and a termination sequence operatively associated with the nucleic acid sequence. The invention further provides methods of making the tissue factor protein, or functional fragment thereof, using the claimed vectors and plants, and methods of treating or preventing blood loss, of promoting wound healing, promoting angiogenesis, or promoting vascular remodeling in a subject by administering the tissue factor proteins to a subject.
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公开(公告)号：EP1546188A2
公开(公告)日：2005-06-29
申请号：EP02746470.0
申请日：2002-06-05
发明人： SHERMAN, Linda, A. , CARD, Kimberlyn, F. , WEIDANZ, Jon, A. , WONG, Hing, C. , THOMSON, Elizabeth, L.
CPC分类号： C07K14/7051 , A61K38/00
摘要： The invention provides T-cell receptor (TCR) molecules that bind peptides derived from the p53 protein, preferably, the human p53 protein. The TCR molecules include both heterodimeric molecules and single chain molecules which specifically bind a sequence preferably spanning about amino acid positions 264 to 272 of the p53 protein displayed in the context of an HLA molecule, preferably, HLA-A2.1. Also disclosed are methods for making and using such TCR molecules. The invention has a wide spectrum of useful applications including therapeutic uses and use in the detection of cells expressing p53 protein.
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