公开(公告)号：EP2421819B1

公开(公告)日：2014-03-05

申请号：EP10718104.2

申请日：2010-04-08

申请人： Bracco Imaging S.p.A

发明人： CITTERIO, Attilio ,  LATTUADA, Luciano ,  FERRIGATO, Aurelia ,  FRETTA, Roberta ,  MAZZON, Roberta ,  MELI, Gabriele ,  LEONARDI, Gabriella ,  UGGERI, Fulvio ,  VIGNALE, Evelin ,  VISIGALLI, Massimo

IPC分类号： C07C227/16

CPC分类号： C07C227/16 ,  C07C229/62

公开(公告)号：EP2694471A1

公开(公告)日：2014-02-12

申请号：EP12712124.2

申请日：2012-04-05

申请人： Bracco Imaging S.p.A

发明人： ANELLI, Pier Lucio ,  ARGESE, Maria ,  BOI, Valeria ,  CAVALIERI, Livio ,  GALIMBERTI, Laura ,  GAZZETTO, Sonia ,  LATTUADA, Luciano ,  MAISANO, Federico ,  RIVOLTA, Giovanni ,  VELLA, Fulvia

IPC分类号： C07C303/08 ,  C07C309/42 ,  A61K31/198 ,  G01N33/53

CPC分类号： C07C303/24 ,  C07C303/44 ,  G01N33/78 ,  C07C305/24

摘要： The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L- tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.

摘要翻译： 本发明涉及通过从相应的方法开始制备3,5-二碘-O- [3-碘-4-（磺酰氧基）苯基] -L-酪氨酸衍生物（T3S）的单钠盐的方法 酚类化合物，在氯磺酸和二甲基乙酰胺作为溶剂的存在下。 如此获得的T3S化合物可以以良好的收率方便地以纯形式分离为固体。 本发明还涉及T3S制备方法，其中起始试剂是T2，并且还包含片剂中这种化合物的制剂。 此外，本发明公开了基于T3S衍生物的非放射性免疫测定法。

公开(公告)号：EP2555803A1

公开(公告)日：2013-02-13

申请号：EP11712872.8

申请日：2011-04-08

申请人： Bracco Imaging S.p.A

发明人： AIME, Silvio ,  GIOVENZANA, Giovanni, Battista ,  TEDOLDI, Fabio ,  MAIOCCHI, Alessandro ,  UGGERI, Fulvio ,  JENSEN, Pernille, Rose ,  KARLSSON, Magnus ,  LERCHE, Mathilde, H. ,  VISIGALLI, Massimo ,  CROSETTI, Marco ,  POGGI, Luisa

IPC分类号： A61K49/10

CPC分类号： A61K49/10 ,  A61B5/055 ,  A61M5/007

摘要： The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.

公开(公告)号：EP1904460B1

公开(公告)日：2012-05-16

申请号：EP06777373.9

申请日：2006-06-20

申请人： BRACCO IMAGING S.p.A.

发明人： GIOVENZANA, Giovanni B., Bracco Imaging S.p.A. ,  PALMISANO, Giovanni, Bracco Imaging S.p.A. ,  SISTI, Massimo, Bracco Imaging S.p.A. ,  CAVALLOTTI, Camilla, Bracco Imaging S.p.A. ,  AIME, Silvio, Bracco Imaging S.p.A. ,  CALABI, Luisella, Bracco Imaging S.p.A. ,  SWENSON, Rolf, Bracco Research USA ,  KONDAREDDIAR, Ramalingam, Bracco Research USA ,  LATTUADA, Luciano, Bracco Imaging S.p.A. ,  MOROSINI, Pierfrancesco, Bracco Imaging S.p.A.

IPC分类号： C07D243/08 ,  C07D243/14 ,  C07C229/16 ,  C07F9/38 ,  A61K49/14

CPC分类号： C07C209/62 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/106 ,  A61K49/122 ,  A61K49/14 ,  A61K51/088 ,  C07D243/08 ,  C07D243/14 ,  C07F9/301 ,  C07F9/3808 ,  C07F9/4816 ,  C07F9/645 ,  C07C211/50

摘要： Compounds of general formula (I): in which: R1, R2, R3, R4, R5 and FG are as defined in the specification and claims, optionally conjugated with a suitable molecule able to interact with physiological systems; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes, as well as the salts thereof with physiologically compatible bases or acids.

公开(公告)号：EP1522875B1

公开(公告)日：2012-03-21

申请号：EP03425639.6

申请日：2003-09-30

申请人： Esaote S.p.A. ,  Bracco Imaging S.p.A

发明人： Pedrizzetti, Gianni ,  Tonti, Giovanni

IPC分类号： G01S15/89 ,  A61B8/08 ,  G01S7/52

CPC分类号： A61B8/0883 ,  A61B8/08 ,  A61B8/0891 ,  A61B8/485 ,  A61B8/486 ,  G01S7/52036 ,  G01S7/52046 ,  G01S7/52063 ,  G01S7/52069 ,  G01S15/8981 ,  G01S15/8993 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/251 ,  G06T2207/10016 ,  G06T2207/10132 ,  G06T2207/30048

公开(公告)号：EP2408735A1

公开(公告)日：2012-01-25

申请号：EP10708209.1

申请日：2010-03-12

申请人： Bracco Imaging S.p.A

发明人： ANELLI, Pier Lucio ,  BROCCHETTA, Marino ,  FRETTA, Roberta ,  LATTUADA, Luciano ,  MORTILLARO, Armando

IPC分类号： C07C231/10 ,  C07C235/16 ,  C07C237/52

CPC分类号： C07C237/46 ,  C07C231/02 ,  C07C231/10 ,  C07C235/16

摘要： The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available α-hydroxyacid or a salt thereof.

公开(公告)号：EP1469890B1

公开(公告)日：2011-08-10

申请号：EP03702538.4

申请日：2003-01-27

申请人： BRACCO IMAGING S.p.A.

发明人： AIME, Silvio ,  DELLI CASTELLI, Daniela ,  FEDELI, Franco ,  TERRENO, Enzo

IPC分类号： A61K49/06

CPC分类号： A61K49/0002 ,  A61K49/106

摘要： A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.

公开(公告)号：EP2349350A1

公开(公告)日：2011-08-03

申请号：EP09783592.0

申请日：2009-09-30

申请人： Bracco Imaging S.p.A

发明人： REINERI, Francesca ,  VIALE, Alessandra ,  GIOVENZANA, Giovanni Battista ,  SANTELIA, Daniela ,  DASTRU', Walter ,  GOBETTO, Roberto ,  AIME, Silvio ,  UGGERI, Fulvio

IPC分类号： A61K49/10

CPC分类号： A61K49/10

摘要： The invention relates to a one-step process for the preparation of aqueous solutions of hyperpolarized molecules in which, in a single step, the said hyperpolarized molecules are separated from the crude solution by means of a fast phase-transfer extraction and isolated in an impurity-free aqueous solution, ready for use in the MRI diagnostic imaging of organs, region or tissues of the human or animal body.

公开(公告)号：EP2206506A1

公开(公告)日：2010-07-14

申请号：EP08172103.7

申请日：2008-12-18

申请人： Bracco Imaging S.p.A

发明人： De Haen, Christoph ,  Gozzini, Luigia

IPC分类号： A61K35/74 ,  A61P1/00 ,  A61P31/00 ,  A61K31/00

CPC分类号： A61K9/02 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/0095 ,  A61K31/00 ,  A61K35/745 ,  A61K35/747 ,  A61K45/06

摘要： The present invention relates to probiotic compositions and kits comprising live bacteria belonging to the natural flora of the human body cavity like intestine and vaginal tract, in particular strains of lactobacillus or bifidobacterium species, and small-molecular-weight non-proteinaceous iron chelators capable of lowering the iron concentration over the whole physiological pH-range of relevance to levels that inhibit growth of pathogens, but which allow for the growth of the bacteria of the composition.

摘要翻译： 本发明涉及益生菌组合物和试剂盒，其包括属于人体腔的天然菌群如肠和阴道，特别是乳杆菌属或双歧杆菌属物种的活细菌，以及能够使用的小分子量非蛋白质铁螯合剂 在与抑制病原体生长但允许组合物细菌生长相关的整个生理pH范围内降低铁浓度。

公开(公告)号：EP1478277B1

公开(公告)日：2010-03-24

申请号：EP02707099.4

申请日：2002-02-27

申请人： Amid SRL ,  Esaote S.p.A. ,  Bracco Imaging S.p.A

发明人： PEDRIZZETTI, Gianni ,  MARCHESE, Emidio ,  TONTI, Giovanni

IPC分类号： A61B8/08

CPC分类号： G06T7/0012 ,  A61B8/0858 ,  G06T7/215 ,  G06T2207/10132 ,  G06T2207/30048 ,  G06T2207/30101