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公开(公告)号：EP4391911A1
公开(公告)日：2024-07-03
申请号：EP21773291.6
申请日：2021-08-26
CPC分类号： A61B5/1473 , G01N33/76 , G01N33/78 , G16H50/30 , G16H20/17 , G16H20/10 , G16H50/20 , G16H40/63 , A61B5/4839 , A61B5/14546 , A61B5/686 , A61B5/725 , A61B5/14503
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公开(公告)号：EP2406630B1
公开(公告)日：2018-01-17
申请号：EP10751173.5
申请日：2010-02-25
CPC分类号： G01N33/78 , G01N33/582 , G01N2333/59
摘要： Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and a chemiluminescent composition comprising an olefinic compound and a metal chelate. In embodiments of an assay, a combination is provided that comprises a sample suspected of containing the analyte, a chemiluminescent reagent as described above and a sensitizer reagent capable of generating singlet oxygen. The combination is subjected to conditions for binding of the analyte to the binding partner for the analyte. The sensitizer is activated and the amount of luminescence generated by the chemiluminescent composition is detected wherein the amount of luminescence is related to the amount of the analyte in the sample.
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公开(公告)号：EP2788756B1
公开(公告)日：2017-11-29
申请号：EP12855407.8
申请日：2012-11-30
发明人： BANKS, J. Fred , CHOU, Peter P. , MATT, Noriya M.
CPC分类号： H01J49/04 , G01N30/7233 , G01N33/6848 , G01N33/78 , G01N2560/00 , H01J49/00 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0081 , H01J49/0431 , H01J49/10
摘要： Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.
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4.发明公开BIOTIN CONJUGATES OF ANALYTES CONTAINING AMINO, HYDROXYL, OR THIOL FUNCTIONAL GROUPS FOR USE IN IMMUNODIAGNOSTIC ASSAYS 审中-公开用于免疫诊断试验的含有氨基，羟基或硫醇官能团的分析物的生物素缀合物
公开(公告)号：EP3230290A1
公开(公告)日：2017-10-18
申请号：EP15867955.5
申请日：2015-12-08
申请人： Calbiotech Inc. , Yohannes, Yonas
发明人： YOHANNES, Yonas
IPC分类号： C07D495/04 , A61K47/50 , G01N33/74 , G01N33/82 , G01N33/92
CPC分类号： G01N33/743 , C07C401/00 , C07D495/04 , G01N33/54393 , G01N33/78 , G01N33/82
摘要： The present disclosure provides a compound having Formula I: or a pharmaceutically acceptable salt of hydrate thereof, wherein R1, A, m, and n are as described herein, for use in conducting immunodiagnostic assays for accurately measuring concentrations of circulating vitamin D, as well as for thyroxine and related analytes, estrogen and related analytes, and testosterone and related analytes.
摘要翻译： 本公开提供了具有式（I）的化合物：或其水合物的药学上可接受的盐，其中R 1，A，m和n如本文所述，用于进行免疫诊断测定以准确测量循环维生素D ，以及甲状腺素和相关分析物，雌激素和相关分析物以及睾酮和相关分析物。
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公开(公告)号：EP3099739A4
公开(公告)日：2017-01-11
申请号：EP15743428
申请日：2015-01-29
IPC分类号： C08L23/28 , C08F2/06 , C08F2/46 , C09D133/24
CPC分类号： C09D133/26 , C07C233/20 , C08F2/06 , C08F220/58 , C08F230/02 , C08F2800/10 , C09D123/0869 , C09D133/24 , G01N33/78 , G01N33/82 , C08F220/20 , C08F220/06 , C08F2220/286 , C08F2220/387
摘要： A composition for use as an assay reagent includes a paramagnetic solid support comprising a coating of a synthetic copolymer. The synthetic copolymer comprises two or three of a first copolymerized monomer, a second copolymerized monomer and a third copolymerized monomer and further comprises a polyethylenic backbone.
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6.发明公开SYSTEM AND METHOD FOR DERIVING PARAMETERS FOR HOMEOSTATIC FEEDBACK CONTROL OF AN INDIVIDUAL 审中-公开系统和方法抽放参数对一个人的自我平衡反馈控制
公开(公告)号：EP2928361A4
公开(公告)日：2016-08-03
申请号：EP13860303
申请日：2013-12-05
CPC分类号： G06F19/3437 , A61B5/145 , A61B5/7275 , G01N33/76 , G01N33/78 , G06F17/10
摘要： A method and system of deriving a physiological homeostatic operating set point of an individual comprising the steps of: obtaining a dataset of predetermined number of homeostatic measurements of the individual; fitting the dataset of predetermined number of homeostatic measurements according to a negative exponential decay function; identifying and setting the physiological homeostatic operating set point unique to the individual as the point corresponding to the point of maximum curvature on the fitted negative exponential decay function is disclosed. The method is especially suited for determining the [FT4]-[TSH] set point, which is unique for each individual.
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7.发明公开QUANTIFICATION OF TRANSTHYRETIN AND ITS ISOFORMS 审中-公开QUANTIFIZIERUNG VON TRANSTHYRETIN UND SEINEN ISOFORMEN
公开(公告)号：EP2780690A4
公开(公告)日：2015-12-09
申请号：EP12849435
申请日：2012-11-16
发明人： BUTLER JAMES , HUTABARAT RENTA , ALVAREZ RENE , XIONG BOB , LI LILY Y T
CPC分类号： G01N33/78 , C07K14/575 , C12Q1/37 , G01N30/7233 , G01N33/58 , G01N33/6848 , H01J49/00 , H01J49/0081
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公开(公告)号：EP2943783A1
公开(公告)日：2015-11-18
申请号：EP14703620.6
申请日：2014-01-09
发明人： GOVER, Andy
IPC分类号： G01N27/327 , G01N33/543 , G01N33/78
CPC分类号： G01N27/3276 , G01N33/78 , G01N2333/575 , G01N2800/046
摘要： Some embodiments provide a method for performing a free thyroxin assay. The method may include providing a flow cell that may include a plurality of sensors at least partially coated with a plurality of antibodies that bind to free thyroxin. The method may further provide introducing a sample into the flow cell so that the sample contacts the sensors, and incubating the sample therein for a time. As a result, at least a portion of any free thyroxin within the sample can bind at least some of the antibodies. In addition, the method may include introducing a wash agent into the flow cell to clear the flow cell of any substantial amount of the sample.
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公开(公告)号：EP2573561B1
公开(公告)日：2015-03-11
申请号：EP12184486.4
申请日：2012-09-14
申请人： Fujifilm Corporation
IPC分类号： G01N33/543 , G01N33/78 , G01N33/58
CPC分类号： G01N33/54373 , G01N33/54306 , G01N33/585 , G01N33/78
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公开(公告)号：EP1644743B1
公开(公告)日：2014-11-12
申请号：EP04727197.8
申请日：2004-04-14
发明人： SOLDIN, Steven, J.
IPC分类号： G01N33/78
CPC分类号： G01N33/6848 , G01N33/78 , Y10T436/24
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