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168 条记录 (耗时 0.023 秒)

    TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES
    11.
    发明公开
    TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES 审中-公开
    标记的HEPADNAVIRUS E抗原及其在筛选抗病毒物质中的应用

    公开(公告)号：EP3157944A1

    公开(公告)日：2017-04-26

    申请号：EP15733379.0

    申请日：2015-06-19

    申请人： Drexel University ,  Baruch S. Blumberg Institute ,  F. Hoffmann-La Roche AG

    发明人： GUO, Haitao ,  CAI, Dawei ,  CUCONATI, Andrea ,  JI, Changhua

    IPC分类号： C07K14/005 ,  G01N33/576

    CPC分类号： C07K14/005 ,  C07K2319/40 ,  C07K2319/42 ,  C12N2730/10122 ,  C12N2730/10151 ,  C12N2830/006 ,  G01N33/502 ,  G01N2333/02

    摘要： The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.

    摘要翻译： 本发明涉及用于筛选抗肝炎病毒物质的方法和用途，其中所述物质筛选抑制肝炎病毒如乙型肝炎病毒的共价闭合环状（ccc）DNA的能力。 该方法和用途利用了包含编码标记的肝炎病毒e抗原的核酸序列如乙型肝炎病毒e抗原（HBeAg）的细胞。 此外，本发明提供了编码标记的肝炎病毒e抗原和由其编码的蛋白质的核酸序列。 还提供了用于筛选方法的试剂盒。

    MULTI-TOUCH PIANO KEYBOARD
    12.
    发明授权
    MULTI-TOUCH PIANO KEYBOARD 有权
    多点触摸钢琴键盘

    公开(公告)号：EP2729932B1

    公开(公告)日：2017-04-05

    申请号：EP12735180.7

    申请日：2012-07-06

    申请人： Drexel University

    发明人： MCPHERSON, Andrew ,  KIM, Youngmoo

    IPC分类号： G10H1/02 ,  G10H1/34 ,  G10H7/06 ,  G06F3/044

    CPC分类号： G10H7/06 ,  G06F3/044 ,  G06F2203/04104 ,  G10H1/02 ,  G10H1/344 ,  G10H2220/221 ,  G10H2220/275

    摘要： A musical keyboard touch sensor pad having a plurality of integrated sensors disposed in an array is disclosed. The plurality of integrated sensors represents a keyboard key. A processor is electronically coupled to the plurality of integrated sensors. The processor is programmed to receive signals from several of the plurality of integrated sensors and to generate a sound signal based on input from the several of the plurality of integrated sensors. The output is variable based on the number in the plurality and the location of the plurality in the array. An audio output device is electronically coupled to the processor to generate a sound based on the sound signal. A keyboard using a plurality of the sensor pads as well as a method of generating sounds from the keyboard are also disclosed.

    Thermogelling polymer blends for biomaterial applications
    20.
    发明公开
    Thermogelling polymer blends for biomaterial applications 审中-公开
    用于生物材料应用的热凝胶聚合物混合物

    公开(公告)号：EP2060280A2

    公开(公告)日：2009-05-20

    申请号：EP09000184.3

    申请日：2004-04-30

    申请人： Drexel University ,  Synthes GmbH

    发明人： Clemow, Alastair J., T. ,  Lowman, Anthony, M. ,  Marcolongo, Michele, S.

    IPC分类号： A61L27/52 ,  A61L27/16

    CPC分类号： A61L27/52 ,  A61F2/12 ,  A61F2/30756 ,  A61F2/30965 ,  A61F2/441 ,  A61F2/442 ,  A61F2002/30075 ,  A61F2002/3008 ,  A61F2002/30563 ,  A61F2002/30583 ,  A61F2002/30588 ,  A61F2002/30971 ,  A61F2002/444 ,  A61F2210/0061 ,  A61F2210/0085 ,  A61F2250/0098 ,  A61L27/16 ,  A61L27/26 ,  A61L27/50 ,  A61L31/041 ,  A61L31/14 ,  A61L31/145 ,  A61L2430/38 ,  C08L33/26

    摘要： Thermogelling polymers are described containing poly (n-isopropyl acrylamide). Solutions of this polymer, copolymers or mixtures of the polymer with a second polymer such as poly(ethylene glycol), poly (vinyl pyrrolidone) or poly(vinyl alcohol) are liquids at room temperature and solids at body temperature. Thus, also provided are methods of implanting a hydrogel into a mammal by injecting the solution as a liquid at a temperature below body temperature into a selected site in the mammal at a temperature below body temperature, which then undergoes thermal phase transition to form a solid hydrogel in situ in the body as the implant warms to body temperature. Methods for using these thermal gelling materials in various applications including nucleus pulposus replacement/augmentation, wound care, disk replacement, cartilage replacement, joint replacement, surgical barriers, gastrointestinal devices, cosmetic and reconstructive surgery, and breast enlargement are also provided.

    摘要翻译： 描述了包含聚（n-异丙基丙烯酰胺）的热凝胶聚合物。 该聚合物，聚合物与第二聚合物如聚（乙二醇），聚（乙烯基吡咯烷酮）或聚（乙烯醇）的共聚物或混合物的溶液在室温下为液体且在体温下为固体。 因此，还提供了通过在低于体温的温度下将溶液作为液体注射到哺乳动物中选择的位置，在低于体温的温度下将水凝胶植入哺乳动物的方法，所述温度然后经历热相转变以形成固体 随着植入物温度升高到体温，体内原位水凝胶。 还提供了在各种应用中使用这些热凝胶材料的方法，所述应用包括髓核置换/增大，伤口护理，椎间盘置换，软骨置换，关节置换，手术屏障，胃肠装置，美容和再造手术以及乳房增大。