公开(公告)号：EP3747479B1

公开(公告)日：2024-05-29

申请号：EP19758085.5

申请日：2019-02-19

IPC: A61L29/04 ,  A61F2/82 ,  A61L29/06 ,  A61L29/08 ,  A61L29/12 ,  A61L29/14 ,  A61L31/04 ,  A61L31/10 ,  A61L31/12 ,  A61L31/14 ,  A61M25/00 ,  A61M25/09 ,  A61L31/06

CPC classification number: A61M25/00 ,  A61L31/10 ,  A61M25/09 ,  A61F2/82 ,  A61L29/085 ,  A61L31/145 ,  A61L29/145 ,  A61L2420/0820130101 ,  A61L2400/1020130101

公开(公告)号：EP3106201B1

公开(公告)日：2018-11-21

申请号：EP16170561.1

申请日：2016-05-20

Applicant: BIOTRONIK SE & Co. KG

Inventor： Kolberg, Gernot ,  Friedrich, Michael

IPC: A61N1/04 ,  A61N1/08 ,  A61N1/18 ,  A61N1/05

CPC classification number: H01B17/58 ,  A61B5/042 ,  A61B5/6879 ,  A61L24/0031 ,  A61L24/043 ,  A61L24/046 ,  A61L24/06 ,  A61L27/16 ,  A61L27/18 ,  A61L27/26 ,  A61L27/52 ,  A61L29/041 ,  A61L29/049 ,  A61L29/06 ,  A61L29/085 ,  A61L29/145 ,  A61L31/041 ,  A61L31/048 ,  A61L31/06 ,  A61L31/145 ,  A61L2400/18 ,  A61N1/05 ,  A61N1/056 ,  A61N1/057 ,  A61N1/0573 ,  A61N1/059 ,  A61N2001/0582 ,  B32B3/06 ,  B32B3/08 ,  B32B3/263 ,  B32B27/08 ,  B32B27/283 ,  B32B27/32 ,  B32B2307/7242 ,  B32B2535/00 ,  C08L83/04 ,  A61L27/34 ,  A61L31/10

公开(公告)号：EP2468310B1

公开(公告)日：2018-11-14

申请号：EP12150108.4

申请日：2007-08-01

Applicant: Baxter International Inc. ,  Baxter Healthcare S.A.

Inventor： Rhee, Woonza M ,  Reich, Cary J ,  Osawa, Edward A ,  Vega, Felix

IPC: A61L24/00 ,  A61L24/06 ,  A61L31/04 ,  A61L31/14 ,  A61L24/10 ,  A61L27/40 ,  A61L27/56

CPC classification number: A61K47/42 ,  A61K9/70 ,  A61K38/363 ,  A61K38/4833 ,  A61K47/34 ,  A61L24/001 ,  A61L24/0031 ,  A61L24/06 ,  A61L31/044 ,  A61L31/145 ,  A61L31/146 ,  Y10T428/249983 ,  C08L71/02

Abstract: Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.

公开(公告)号：EP2276471B1

公开(公告)日：2018-08-08

申请号：EP09739174.2

申请日：2009-04-29

Applicant: Mati Therapeutics Inc.

Inventor： SIM, Sylvie ,  JAIN, Rachna ,  FARINAS, Kathleen

IPC: A61K9/32 ,  A61K47/34

CPC classification number: A61L31/06 ,  A61F9/0008 ,  A61F9/0017 ,  A61K9/0051 ,  A61K47/34 ,  A61L31/145 ,  A61L31/16

Abstract: Lacrimal implants, methods of making lacrimal implants, and methods of treating ocular, respiration or other diseases or disorders using lacrimal implants are disclosed.

公开(公告)号：EP3229851A4

公开(公告)日：2018-08-01

申请号：EP15867618

申请日：2015-12-09

Applicant: TANGIBLE SCIENCE LLC

Inventor： HAVENSTRITE KAREN ,  MCCRAY VICTOR W ,  FELKINS BRANDON M ,  COOK PAUL

IPC: A61L27/00 ,  A61L15/00 ,  A61L29/00 ,  A61L31/00

CPC classification number: A61L29/145 ,  A61L15/46 ,  A61L15/60 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2400/12

Abstract: Medical devices with a hydrogel layer covalently attached to a portion of the outer surface of the medical device are provided along with methods for applying the coating. The hydrogel layer can include a first polymer species comprising polyethylene glycol (PEG) and a second polymer species. Examples of the second polymer species include PEG and polyacrylamide (PAM). The first and second species can be at least partially cross-linked. Methods for forming the hydrogel coatings on the medical devices are provided including nucleophilic conjugate reactions, such as Click reactions.

公开(公告)号：EP3250255A1

公开(公告)日：2017-12-06

申请号：EP16744019.7

申请日：2016-01-27

Applicant: The Texas A&M University System

Inventor： GRUNLAN, Melissa A. ,  COTE, Gerard L. ,  ABRAHAM, Alexander A. ,  FEI, Ruochong ,  LOCKE, Andrea K.

IPC: A61M5/00

CPC classification number: A61L31/048 ,  A61B5/14532 ,  A61B5/1473 ,  A61L31/10 ,  A61L31/145 ,  C08F220/56 ,  C08L33/26 ,  C08L2203/02

Abstract: The disclosure provides a method for cleaning an implanted medical device. In one embodiment, the method includes providing a medical device including a membrane; wherein the membrane comprises a thermoresponsive hydrogel including N-isopropylacrylamide (NIPAAm) or poly(N-isopropylacrylamide) (PNIPAAm), and a volume phase transition temperature (VPTT). The method also includes implanting the medical device into a target area; wherein the membrane temperature is maintained at substantially the same temperature as the target area; wherein temperature fluctuations within the target area that approach, meet and/or exceed the volume phase transition temperature induce deswelling or relative deswelling in the membrane and temperature fluctuations within the target area that are relatively lower and/or approach and/or fall below the volume phase transition temperature induce swelling or relative swelling in the membrane.

公开(公告)号：EP3250251A1

公开(公告)日：2017-12-06

申请号：EP16705622.5

申请日：2016-01-28

Applicant: ALLERGAN, INC.

Inventor： JIANG, Guang-Liang ,  TURKEL, Catherine C. ,  STERN, Michael ,  SCHAUMBURG, Christopher S. ,  BLANDA, Wendy

IPC: A61L31/04 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/042 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/402 ,  A61L2300/41 ,  A61L2300/426 ,  A61L2300/43 ,  A61L2300/622 ,  A61L2300/624 ,  A61L2400/06 ,  A61L2430/24 ,  C08L5/08

Abstract: The present invention relates to formulations for administration to a joint fat pad of a subject, and to methods of treating joint pain, inflammation or disease. The disclosed formulations are intended for local administration to the joint fat pad to provide sustained release of a therapeutic agent to the joint cavity and surrounding tissues. The joint may be an arthritic joint, an injured joint or a surgically replaced joint. The therapeutic agent may be an analgesic agent, an anti-inflammatory agent or an immunosuppressive agent. A single administration of the formulation to the joint fat pad delivers a therapeutically effective amount of the therapeutic agent with reduced systemic exposure relative to a single systemic or a single intra-articular administration of a therapeutic dose of an identical therapeutic agent.

公开(公告)号：EP2392365B1

公开(公告)日：2017-12-06

申请号：EP11173830.8

申请日：2007-06-15

Applicant: MicroVention, Inc.

Inventor： Cruise, Gregory

IPC: A61L31/04 ,  A61L31/06 ,  A61L31/14

CPC classification number: A61B17/1219 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/12154 ,  A61B17/12168 ,  A61L31/00 ,  A61L31/022 ,  A61L31/041 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/145 ,  A61L31/146 ,  A61L2400/04 ,  C08L71/02

Abstract: A method for preparing an environmentally-responsive hydrogel for implantation in an animal comprising: a) combining at least one ethylenically unsaturated macromer, at least one macromer or monomer comprising at least one ionizable functional group, at least one polymerization initiator, and at least one solvent to prepare a hydrogel; b) treating said hydrogel to prepare an environmentally-responsive hydrogel that is responsive at physiological conditions.

公开(公告)号：EP3071286A4

公开(公告)日：2017-09-06

申请号：EP14864511

申请日：2014-11-21

Applicant: FRACTYL LABORATORIES INC

Inventor： RAJAGOPALAN HARITH ,  CAPLAN JAY ,  FLAHERTY R MAXWELL ,  FLAHERTY J CHRISTOPHER

IPC: A61M31/00 ,  A61F2/02 ,  A61N1/30

CPC classification number: A61M25/0084 ,  A61F5/0013 ,  A61F5/0076 ,  A61F2005/0016 ,  A61K31/728 ,  A61K33/42 ,  A61K35/33 ,  A61K35/35 ,  A61K45/06 ,  A61L31/043 ,  A61L31/048 ,  A61L31/06 ,  A61L31/145 ,  A61L31/16 ,  A61M25/00 ,  A61M25/0082 ,  A61M31/00 ,  A61M2025/0089 ,  A61M2025/0096 ,  A61N1/306

公开(公告)号：EP2407479B2

公开(公告)日：2017-08-23

申请号：EP10750643.8

申请日：2010-02-12

Applicant: Menicon Co., Ltd. ,  National University Corporation Okayama University

Inventor： NAGAI, Yusuke ,  YOKOI, Hidenori ,  UESUGI, Koji ,  NARUSE, Keiji

IPC: C07K7/08 ,  C12N5/07

CPC classification number: C07K7/08 ,  A61K8/64 ,  A61K9/0048 ,  A61K9/06 ,  A61K38/10 ,  A61K47/42 ,  A61L15/60 ,  A61L27/227 ,  A61L27/52 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  A61Q5/00 ,  A61Q19/00 ,  B01J20/28047 ,  C10M173/02 ,  C12N5/0068 ,  C12N5/0656 ,  C12N5/0658 ,  C12N2533/50