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    Pharmaceutical composition comprising factor VII encapsulated in micelles
    13.
    发明公开
    Pharmaceutical composition comprising factor VII encapsulated in micelles 审中-公开
    Pharmazutische Zusammensetzung entmaltend Faktor VII在Mizellen verkapselt

    公开(公告)号：EP2554161A1

    公开(公告)日：2013-02-06

    申请号：EP11176276.1

    申请日：2011-08-02

    申请人： LFB Biotechnologies ,  NanoCarrier Co., Ltd.

    发明人： Perret, Gérald ,  Chtourou, Sami ,  Bihoreau, Nicolas

    IPC分类号： A61K9/107 ,  A61K38/36 ,  A61K47/34 ,  A61K9/00 ,  A61P7/04

    CPC分类号： A61K38/4846 ,  A61K9/1075 ,  A61K9/1641 ,  A61K9/19 ,  A61K38/36

    摘要： The invention relates to a pharmaceutical composition comprising factor VII encapsulated in micelles formed from block copolymer molecules containing (i) a hydrophilic polymer segment consisting of a polyalkylene glycol and (ii) a hydrophobic polymer segment consisting of a polyamino acid, with said polyamino acid comprising exclusively amino acid residues selected from the goup consisting of histidine, lysine, aspartic acid and glutamic acid residues, wherein a part of said amino acid residues is substituted with a hydrophobic group.

    摘要翻译： 本发明涉及包含由嵌段共聚物分子形成的胶束中包含的因子VII的药物组合物，所述嵌段共聚物分子包含（i）由聚亚烷基二醇组成的亲水性聚合物链段和（ii）由聚氨基酸组成的疏水性聚合物链段，所述聚氨基酸包含 选自由组氨酸，赖氨酸，天冬氨酸和谷氨酸残基组成的组的专一氨基酸残基，其中所述氨基酸残基的一部分被疏水基团取代。

    DERIVES DE N- (AMINO-HETEROARYL) - 1H-INDOLE-2 -CARBOXAMIDES COMME ANTAGONISTES DES RECEPTEURS DE TYPE TRPV1 OU VR1
    18.
    发明授权
    DERIVES DE N- (AMINO-HETEROARYL) - 1H-INDOLE-2 -CARBOXAMIDES COMME ANTAGONISTES DES RECEPTEURS DE TYPE TRPV1 OU VR1 有权
    N-（氨基杂芳基）-1H-吲哚-2-甲酰胺衍生物及其制备和治疗用途

    公开(公告)号：EP2046775B1

    公开(公告)日：2012-08-22

    申请号：EP07823311.1

    申请日：2007-07-20

    申请人： SANOFI

    发明人： DUBOIS, Laurent ,  EVANNO, Yannick ,  MALANDA, André

    IPC分类号： C07D401/12 ,  A61K31/435 ,  A61P25/00 ,  A61P29/00 ,  A61P17/00 ,  A61P3/00 ,  A61P15/00 ,  A61P13/00 ,  A61P31/00 ,  A61P11/00

    CPC分类号： C07D401/12

    摘要： The invention relates to compounds of general formula (I): in which X1 is a hydrogen or halogen atom or a (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)-alkylene, (C1-C6)-fluoroalkyl, cyano, C(O)NR1R2, nitro, (C1-C6)-thioalkyl, -S(O)-(C1-C6)-alkyl, -S(O)2-(C1-C6)-alkyl, SO2NR1R2, aryl-(C1-C6)-alkylene, aryl or heteroaryl group, the aryl and the heteroaryl being optionally substituted; X2 is a hydrogen or halogen atom or a (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)-alkylene, (C1-C6)-fluoroalkyl, (C1-C6)-alkoxyl, (C3-C7)-cycloalkyl-(C1-C6)-alkylene-O-, (C1-C6)-fluoroalkoxyl, cyano, C(O)NR1R2, (C1-C6)-thioalkyl, -S(O)-(C1-C6)-alkyl, -S(O)2-(C1-C6)-alkyl, SO2NR1R2, aryl-(C1-C6)-alkylene, aryl or heteroaryl group, the aryl and the heteroaryl being optionally substituted; X3 and X4 are, independently of one another, a hydrogen or halogen atom or a (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)-alkylene, (C1-C6)-fluoroalkyl, (C1-C6)-alkoxyl, (C3-C7)-cycloalkyl-(C1-C6)-alkylene-O-, (C1-C6)-fluoroalkoxyl, cyano, C(O)NR1R2, nitro, NR1R2, (C1-C6)-thioalkyl, -S(O)-(C1-C6)-alkyl, -S(O)2-(C1-C6)-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5, aryl-(C1-C6)-alkylene, aryl or heteroaryl group, the aryl and the heteroaryl being optionally substituted; Z1, Z2, Z3 and Z4 are, independently of one another, a nitrogen atom or a C(R6) group; n is equal to 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; Ra and Rb are, independently of one another, a hydrogen atom or a (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)-alkylene, (C1-C6)-fluoroalkyl, hydroxyl, (C1-C6)-alkoxyl, (C3-C7)-cycloalkyl-(C1-C6)-alkylene-O-, (C1-C6)-fluoroalkoxyl, aryl or heteroaryl group, wherein Ra and Rb may be optionally substituted; in the form of a base or an addition salt with an acid, and also in the form of a hydrate or of a solvate. Process for the preparation thereof and therapeutic use.

    COSMETIC KIT FOR MAKING UP AND/OR FOR CARE OF KERATINOUS MATERIAL
    20.
    发明公开
    COSMETIC KIT FOR MAKING UP AND/OR FOR CARE OF KERATINOUS MATERIAL 有权
    用化妆品彩妆和/或护理角质

    公开(公告)号：EP2475285A1

    公开(公告)日：2012-07-18

    申请号：EP10763857.9

    申请日：2010-09-10

    申请人： L'Oréal

    发明人： RICARD, Audrey

    IPC分类号： A45D34/04

    CPC分类号： A45D34/041 ,  A45D2200/1018 ,  A45D2200/1027

    摘要： The present invention provides a cosmetic kit for makeup and/or for care of keratinous material, comprising at least: ° a container containing at least one cosmetic composition comprising, in a physiologically acceptable medium, at least 16% by weight, preferably at least 18% by weight and more preferably at least 20% by weight of pigments and/or of film- forming polymers and/or of non-pulverulent thickening agents, relative to the total weight of said composition, said composition comprising at least one pigment; °an applicator device (8) for applying the composition, provided with an applicator member (10) including an application surface that is capable of turning about at least one axis (x) or center of rotation in response to being moved in engagement with the keratinous material.