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11.发明公开EXPRESSION OF PROTEINS FOR TREATING ASTHMA VIA LIGAND MEDIATED ACTIVATION OF THEIR ENCODING GENES 失效蛋白对性哮喘的配体介导的激活你的基因的表达治疗进行编码
公开(公告)号：EP0948619A1
公开(公告)日：1999-10-13
申请号：EP97949785.0
申请日：1997-12-09
CPC分类号： A61K48/00 , A61K38/2066 , A61K38/208 , A61K38/217 , A61K38/44
摘要： A method for treating or preventing asthma in a mammal involving administering to the mammal an effective dose of a drug capable of activating expression of a recombinant DNA molecule encoding a target protein in genetically engineered cells present within the mammal.
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12.发明公开NEW METHOD FOR IDENTIFYING AND EVALUATING BIOLOGICALLY ACTIVE MOLECULES 无效NEW如此表决AUFFINDENUND生物活性分子
公开(公告)号：EP0787207A1
公开(公告)日：1997-08-06
申请号：EP95941352.0
申请日：1995-11-01
IPC分类号： G01N33
CPC分类号： G01N33/53 , C07K2319/03 , C07K2319/32 , C07K2319/60 , G01N33/531 , G01N2500/00
摘要： This invention concerns materials, methods and applications relating to the multimerizing of protein mediators of biological events using synthetic, preferably non-peptidic, dimerizing agents or CIDs.
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公开(公告)号：EP2032168A1
公开(公告)日：2009-03-11
申请号：EP07795759.5
申请日：2007-06-04
IPC分类号： A61K39/395
CPC分类号： A61K31/337 , A61K31/436 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The invention provides the use of a combination of an mTOR inhibitor and capecitabine in the treatment of cancer.
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14.发明公开BIOMARKERS FOR EVALUATING LIKELIHOOD OF TUMOR SENSITIVITY TO AN MTOR INHIBITOR 审中-公开生物标志物评价中敏感性的肿瘤的的概率任何mTOR抑制剂
公开(公告)号：EP1899463A2
公开(公告)日：2008-03-19
申请号：EP06759344.2
申请日：2006-05-08
IPC分类号： C12N15/09
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N33/57484 , G01N2800/52
摘要： The present invention provides compositions and methods for evaluating the likelihood that a tumor is sensitive to an mTOR inhibitor, e.g., rapamycin or a rapamycin analog. The invention provides FKBP proteins as biomarkers for predicting the likelihood that a tumor is sensitive to an mTOR inhibitor. The methods include assessing the expression or activity of an FKBP protein, e.g., FKBP 12, in a subject with a tumor or in a sample derived from a tumor. Additional biomarkers and biomarker combinations are also provided. The invention also provides kits containing, e.g., a validated antibody or ligand for assessing the expression or activity of an FKBP protein.
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15.发明授权NEW METHOD FOR IDENTIFYING AND EVALUATING BIOLOGICALLY ACTIVE MOLECULES 无效NEW如此表决AUFFINDENUND生物活性分子
公开(公告)号：EP0787207B1
公开(公告)日：2005-10-26
申请号：EP95941352.7
申请日：1995-11-01
CPC分类号： G01N33/53 , C07K2319/03 , C07K2319/32 , C07K2319/60 , G01N33/531 , G01N2500/00
摘要： This invention concerns materials, methods and applications relating to the multimerizing of protein mediators of biological events using synthetic, preferably non-peptidic, dimerizing agents or CIDs.
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公开(公告)号：EP0776327B1
公开(公告)日：2005-07-06
申请号：EP95930217.5
申请日：1995-08-18
发明人： HOLT, Dennis, A. , LABORDE, Edgardo , KEENAN, Terence , GUO, Tao
IPC分类号： C07D471/04 , C07D471/10 , C07D471/14 , C07D471/20 , C07D471/22 , C07D487/04 , C07D487/10 , C07D487/14 , C07D487/20 , C07D487/22 , C07D211/60 , C07D401/14 , C07D401/12
CPC分类号： C07D401/14 , C07D207/16 , C07D211/60 , C07D401/12 , C07D405/12
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公开(公告)号：EP1144655A3
公开(公告)日：2001-12-19
申请号：EP99955001.5
申请日：1999-10-19
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公开(公告)号：EP1144655A2
公开(公告)日：2001-10-17
申请号：EP99955001.5
申请日：1999-10-19
CPC分类号： C07K14/62 , A01K2217/05 , C07K14/47 , C07K14/4702 , C07K14/811 , C07K2319/00 , C07K2319/03 , C07K2319/04 , C07K2319/09 , C07K2319/32 , C07K2319/50 , C07K2319/60 , C07K2319/71 , C07K2319/715 , C07K2319/75 , C07K2319/81 , C12N15/625 , C12N2799/022
摘要： Materials and methods involving conditional retention domains (CRDs) are disclosed. A conditional retention domain is any domain which is retained in the ER or other secretory compartment in the absence of ligand and is released from the secretory machinery when ligand is bound, i.e. in the presence of ligand. Also disclosed are fusion proteins containing CRDs and cells expressing such fusion proteins. In addition, the invention provides novel methods for producing target proteins in vivo using fusion proteins containing conditional retention domains and methods for identifying novel CRDs.
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公开(公告)号：EP1078096A1
公开(公告)日：2001-02-28
申请号：EP99922872.9
申请日：1999-05-10
发明人： WILSON, James , RIVERA, Victor , GILMAN, Michael , YE, Xuehai
CPC分类号： C12N15/86 , C12N2710/10344 , C12N2750/14143 , C12N2830/00 , C12N2830/42 , C12N2830/85 , C12N2840/203
摘要： The invention provides improved compositions and methods for using them in gene therapy.
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20.发明公开FUSION PROTEINS COMPRISING A DIMERIZATION, TRIMERIZATION OR TETRAMERIZATION DOMAIN AND AN ADDITIONAL HETEROLOGOUS TRANSCRIPTION ACTIVATION, TRANSCRIPTION REPRESSION, DNA BINDING OR LIGAND BINDING DOMAIN 审中-公开融合蛋白二聚，三聚或四聚结构域和额外的异源转录激活，转录抑制，DNA结合区和配体结合域包
公开(公告)号：EP1017829A2
公开(公告)日：2000-07-12
申请号：EP98942265.4
申请日：1998-08-26
CPC分类号： C12N15/67 , A61K38/00 , C07K14/005 , C07K14/39 , C07K14/4705 , C07K2319/00 , C12N15/1055 , C12N2710/16622
摘要： The present invention relates to novel fusion proteins which activate transcription, to nucleic acid constructs encoding the proteins and their use in the genetic engineering of cells. Key fusion proteins of the invention contain at least two mutually heterologous domains, one of which being a bundling domain. Bundling domains include any domain that induces proteins that contain it to form multimers ('bundles') through protein-protein interactions with each other or with other proteins containing the bundling domain. Examples of bundling domains that can be used in the practice of this invention include domains such as the lac repressor tetramerization domain, the p53 tetramerization domain, a leucine zipper domain, and domains derived therefrom which retain observable bundling activity. Cells are engineered by the introduction of recombinant nucleic acids encoding the fusion proteins, and in some cases with additional nucleic acid constructs, to render them capable of ligand-dependent regulation of transcription of a target gene. Administration of the ligand to the cells then regulates (positively, or in some cases, negatively) target gene transcription.
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