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33 条记录 (耗时 0.018 秒)

    MERCURY BINDING POLYPEPTIDES AND NUCLEOTIDES CODING THEREFOR
    12.
    发明公开
    MERCURY BINDING POLYPEPTIDES AND NUCLEOTIDES CODING THEREFOR 失效
    MERCURY结合多肽与此编码核苷酸

    公开(公告)号：EP0741749A1

    公开(公告)日：1996-11-13

    申请号：EP95908736.0

    申请日：1995-01-27

    申请人： BIONEBRASKA, INC.

    发明人： LOPEZ, Osvaldo ,  WYLIE, Dwane E. ,  WAGNER, Fred W.

    IPC分类号： A62D3 ,  C07K16 ,  C12N15 ,  A62D101

    CPC分类号： A62D3/33 ,  A62D2101/43 ,  C07K16/44 ,  C07K2319/00

    摘要： Metal binding polypeptides which include an amino acid sequence coding for a variable region of a monoclonal antibody which immunoreacts with a mercury cation and nucleotides which include a nucleic acid sequence coding for the variable region are provided. The invention is also directed to fusion proteins which include a phage coat protein or portion thereof and the monoclonal antibody heavy chain variable region. The invention also provides bacteriophages which include the fusion protein in their coat. In addition, methods for detecting, removing, adding, or neutralizing mercuric cations in biological or inanimate systems through the use of the mercury binding polypeptides are provided.

    Monoclonal antibodies for small organic molecules
    13.
    发明公开
    Monoclonal antibodies for small organic molecules 失效
    MonoklonaleAntikörperngegen kleine organische Molekylen。

    公开(公告)号：EP0589487A1

    公开(公告)日：1994-03-30

    申请号：EP93116126.9

    申请日：1990-03-14

    申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  BIONEBRASKA, INC.

    发明人： Wagner, Fred W. ,  Wylie, Dwane E. ,  Schuster, Sheldon M. ,  Coolidge, Thomas R. ,  Song, Pill-Soon ,  Parker, William

    IPC分类号： C12P21/08 ,  C12N5/16 ,  G01N33/53 ,  G01N33/84 ,  C07K15/28

    CPC分类号： C07K16/44 ,  C07K2317/55 ,  G01N33/5308 ,  G01N33/54353 ,  G01N33/68 ,  G01N33/84

    摘要： The present invention is directed to monoclonal antibodies and fragments thereof for immunoreaction with organic compounds having a molecular size of no more than about 15 atoms in length and being a linear or branched aliphatic molecule or a small peptide. The invention is as well directed to hybridomas which produce the monoclonal antibodies, to immunogen compounds of the organic compound which cause development of the appropriate mammalian antibody response and to methods for producing antibody fragments. The invention is further directed to methods for detecting, removing, adding or neutralizing the organic compounds in biological and inanimate systems through the use of the monoclonal antibodies or fragments thereof.

    摘要翻译： 本发明涉及用于与分子大小不超过约15个原子长度并且是直链或支链脂族分子或小肽的有机化合物进行免疫反应的单克隆抗体及其片段。 本发明还针对产生单克隆抗体的杂交瘤，引起合适的哺乳动物抗体应答发展的有机化合物的免疫原化合物和产生抗体片段的方法。 本发明还涉及通过使用单克隆抗体或其片段来检测，除去，添加或中和生物和无生物体系中的有机化合物的方法。

    PURIFICATION DIRECTED CLONING OF PEPTIDES
    14.
    发明公开
    PURIFICATION DIRECTED CLONING OF PEPTIDES 失效
    用于清洁肽某些克隆。

    公开(公告)号：EP0539530A1

    公开(公告)日：1993-05-05

    申请号：EP92902529.0

    申请日：1991-06-24

    申请人： BIONEBRASKA, INC.

    发明人： COOLIDGE, Thomas, R. ,  WAGNER, Fred ,  VAN HEEKE, Gino ,  SCHUSTER, Sheldon, M. ,  STOUT, Jay ,  WYLIE, Dwane, E.

    IPC分类号： C07K14 ,  C07K1 ,  C07K7 ,  C07K19 ,  C12N1 ,  C12N9 ,  C12N15 ,  C12P21 ,  C12R1

    CPC分类号： C12N9/14 ,  C07K7/14 ,  C07K14/245 ,  C07K14/47 ,  C07K14/585 ,  C07K14/595 ,  C07K2319/00 ,  C07K2319/50 ,  C07K2319/75 ,  C12N9/88 ,  C12N15/62

    摘要： Cette invention concerne des procédés utilisant des microbes et des organismes plus évolués pour l'expression et la purification par affinité immobilisée par ligand d'un produit peptidique. Les compositions biologiques de cette invention qui sont réalisées à l'aide de ces procédés contiennent ou bien sont destinées à exprimer une structure de purification de protéine, ayant trois segments couplés en tandem composés d'une protéine de liaison, d'un peptide d'interconnexion et d'un polypeptide à fusion variable qui incorpore le produit peptidique dans une ou plusieurs copies. Suivant le procédé de l'invention, on obtient le produit peptidique comme suit: (a) on exprime une cellule hôte ou un organisme hôte de manière régulée par le vecteur d'expression recombinant portant le gène recombinant codant pour la structure de purification de protéine; (b) on purifie la structure de purification des protéines à l'aide d'une technique de séparation par affinité immobilisée par ligand; et (c) on effectue le clivage chimique ou enzymatique de la structure de purification de protéine pour produire le produit peptidique.

    PEPTIDE PHARMACEUTICAL FORMULATIONS
    18.
    发明公开
    PEPTIDE PHARMACEUTICAL FORMULATIONS 审中-公开
    肽药物制剂

    公开(公告)号：EP1301200A2

    公开(公告)日：2003-04-16

    申请号：EP01941488.7

    申请日：2001-05-17

    申请人： BIONEBRASKA, INC.

    发明人： HOLMQUIST, Barton ,  DORMADY, Daniel, C.

    IPC分类号： A61K38/25 ,  A61K38/26 ,  A61K38/29 ,  A61K47/12 ,  A61K47/26

    摘要： A pharmaceutical composition for administration to a mammal is disclosed. The composition includes a therapeutically effective amount of a peptide, such as a GLP-1 molecule, a PTH molecule, or a GRF molecule. The composition further includes a buffer including a weak acid having an acid dissociation constant value of greater than about 1x10-5, such as acetic acid. The composition also includes an excipient for making the composition generally isotonic, such as D-mannitol.