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公开(公告)号：EP2147926B1
公开(公告)日：2016-08-24
申请号：EP08748432.5
申请日：2008-04-29
发明人： Li, Shaowei , SHEN, Wentong , LI, Zhongyi , XIE, Minghui , PAN, Huirong , XIA, Ningshao
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/20011 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
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12.发明授权MONOCLONAL ANTIBODIES BINDING TO AVIAN INFLUENZA VIRUS SUBTYPE H5 HAEMAGGLUTININ AND USES THEREOF 有权禽流感病毒亚型HA从H5来源的结合的单克隆抗体体和应用
公开(公告)号：EP2174957B1
公开(公告)日：2016-03-16
申请号：EP08772961.2
申请日：2008-06-16
发明人： CHEN, Yixin , LUO, Wenxin , ZHANG, Jun , XIA, Ningshao , GUAN, Yi , CHEN, Honglin
IPC分类号： C07K16/18 , G01N33/53 , G01N33/569 , A61K39/395 , C07K7/06
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
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13.发明授权Monoclonal antibody against hepatitis E virus or its fragment with binding activity and use thereof 有权针对戊型肝炎病毒的单克隆抗体或其具有结合活性的片段及其用途
公开(公告)号：EP2322625B8
公开(公告)日：2016-02-24
申请号：EP10181815.1
申请日：2002-11-08
发明人： Xia, Ningshao , Zhang, Jun , Gu, Ying , Li, Shaowei , Ge, Shengxiang , He, Zhiqiang
IPC分类号： C12N15/13 , C07K16/10 , C07K14/08 , A61K39/29 , A61K39/395 , G01N33/576
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/545 , A61K2039/55505 , A61K2039/55566 , A61K2039/57 , C07K16/10 , C12N2770/28122 , C12N2770/28134 , G01N33/576
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14.发明授权HEPATITIS E VIRUS MONOCLONAL ANTIBODIES OR THE BINDING FRAGMENTS OF IT AND THE USE THEREOF 有权单克隆抗体的戊型肝炎病毒，约束力问题元素，以及它们的用途
公开(公告)号：EP1452541B2
公开(公告)日：2015-06-17
申请号：EP02781056.3
申请日：2002-11-08
发明人： XIA, Ningshao Xiamen University , ZHANG, Jun Xiamen University , GU, Ying Xiamen University , LI, Shaowei Xiamen University , GE, Shengxiang Xiamen University , HE, Zhiqiang Xiamen University
IPC分类号： C12N15/13 , C07K16/10 , C07K14/08 , A61K39/29 , A61K39/395 , G01N33/576
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/545 , A61K2039/55505 , A61K2039/55566 , A61K2039/57 , C07K16/10 , C12N2770/28122 , C12N2770/28134 , G01N33/576
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15.发明授权ORF7 DEFICIENT VARICELLA VIRUS, VACCINE COMPRISING THE VIRUS AND USE THEREOF 有权有补中益气水痘病毒ORF7，该病毒及其用途疫苗
公开(公告)号：EP2460878B1
公开(公告)日：2015-03-25
申请号：EP10803804.3
申请日：2010-07-27
申请人： University of Medicine & Dentistry of New Jersey , Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. , Xiamen University
发明人： ZHU, Hua , LI, Yimin , XIA, Ningshao , CHENG, Tong , YE, Xiangzhong
CPC分类号： C12N7/00 , A61K39/12 , A61K39/25 , A61K2039/5254 , C07K14/005 , C12N15/86 , C12N2710/16722 , C12N2710/16734
摘要： Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.
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16.发明公开Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof 有权AnHämagglutinindes Vogelgrippevirus Subtyp H5 bindende monoklonaleAntikörperund Verwendungdafür
公开(公告)号：EP2716656A1
公开(公告)日：2014-04-09
申请号：EP13166514.3
申请日：2008-06-16
发明人： Chen, Yixin , Luo, Wenxin , Zhang, Jun , Xia, Ningshao , Guan, Yi , Chen, Honglin
IPC分类号： C07K16/18 , C07K16/46 , C12N5/12 , C12N15/13 , C12N15/63 , G01N33/53 , G01N33/569 , A61K39/395 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61P31/16 , C07K14/11 , C07K16/10
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： The present invention provides monoclonal antibodies that bind specifically to H5 subtype avian influenza virus hemagglutinin (HA) proteins, and can block the binding activity of at least 50% of the known monoclonal antibodies to the H5 subtype avian influenza virus hemagglutinin (HA) protein. The monoclonal antibodies can be used for the detection, diagnosis, prevention, and treatment of avian influenza viruses, especially the H5 subtype of avian influenza viruses. The present invention also provides the related hybridoma cell lines, isolated nucleic acid molecules and short peptides, as well as medical composition and medical diagnostic equipment and kit containing the monoclonal antibody.
摘要翻译： 本发明提供了与H5亚型禽流感病毒血凝素（HA）蛋白特异性结合的单克隆抗体，并且可以阻断至少50％的已知单克隆抗体与H5亚型禽流感病毒血凝素（HA）蛋白的结合活性。 单克隆抗体可用于检测，诊断，预防和治疗禽流感病毒，特别是禽流感病毒的H5亚型。 本发明还提供了相关的杂交瘤细胞系，分离的核酸分子和短肽，以及包含单克隆抗体的医药组合物和医学诊断设备和试剂盒。
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公开(公告)号：EP2154148B1
公开(公告)日：2016-06-22
申请号：EP08757380.4
申请日：2008-05-29
发明人： ZHANG, Jun , WANG, Jin , YANG, Chunyan , GU, Ying , LI, Shaowei , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/295 , A61K39/12 , A61P31/20 , A61P15/00 , A61P17/12
CPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
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18.发明授权Monoclonal antibody against hepatitis E virus or its fragment with binding activity and use thereof 有权抗丙型E或其片段具有结合活性的单克隆抗体，并使用它们的
公开(公告)号：EP2322625B1
公开(公告)日：2016-01-06
申请号：EP10181815.1
申请日：2002-11-08
发明人： Xia, Ningshao , Zhang, Jun , Gu, Ying , Li, Shaowei , Ge, Shengxiang , He, Zhiqiang
IPC分类号： C12N15/13 , C07K16/10 , C07K14/08 , A61K39/29 , A61K39/395 , G01N33/576
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/545 , A61K2039/55505 , A61K2039/55566 , A61K2039/57 , C07K16/10 , C12N2770/28122 , C12N2770/28134 , G01N33/576
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公开(公告)号：EP2154149A1
公开(公告)日：2010-02-17
申请号：EP08757381.2
申请日：2008-05-29
发明人： LI, Shaowei , PAN, Huirong , LIU, Bo , ZHANG, Jun , MIAO, Ji , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/12 , A61K39/295 , A61P31/20 , A61P15/00 , A61P17/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55566 , A61K2039/70 , C07K14/025 , C12N7/00 , C12N2700/00 , C12N2710/00 , C12N2710/20022 , C12N2710/20034 , C12P21/00 , G01N2333/025
摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 6, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.
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20.发明公开A TRUNCATED L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 11 有权VERKÜRZTESL1-PROTEIN DES HUMANEN PAPILLOMAVIRUS 11
公开(公告)号：EP2154148A1
公开(公告)日：2010-02-17
申请号：EP08757380.4
申请日：2008-05-29
发明人： ZHANG, Jun , WANG, Jin , YANG, Chunyan , GU, Ying , LI, Shaowei , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/295 , A61K39/12 , A61P31/20 , A61P15/00 , A61P17/12
CPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 11, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.
摘要翻译： 本发明涉及11型人乳头瘤病毒的截短的L1蛋白，由蛋白质组成的病毒样颗粒，包含所述病毒样颗粒的疫苗，以及该疫苗在预防尖锐湿疣或HPV感染中的用途。
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