公开(公告)号：EP1289589B1

公开(公告)日：2004-09-01

申请号：EP01944390.2

申请日：2001-06-08

申请人： Ivax Corporation ,  NORTON HEALTHCARE LIMITED

发明人： HOLROYD, Michael

IPC分类号： A61M15/00

CPC分类号： A61M15/0091 ,  A61M15/009 ,  A61M15/0093 ,  A61M15/0096 ,  Y10T156/10

摘要： A metered dose inhaler for use with a pressurized aerosol container (25) which is preferably breath-actuated. A preload (460) is applied to the internal aerosol valve by an amount sufficient to result in a dose release, but this is prevented by the application of a pneumatic resisting force. The inhaler comprises a release device (520) which, upon actuation, releases the resisting force and allows the preload to actuate the aerosol valve. A metered dose of medicament is then released for inhalation by the patient. The pneumatic resisting force is established by a negative pressure region (600) defined in part by a diaphragm (440). The diaphragm (440) includes a central disk (441) of a first, relatively high stiffness material "A" and a peripheral ring, coupled by a flexure of a second, relatively low stiffness material "B".

摘要翻译： 用于与优选呼气致动的加压气溶胶容器一起使用的计量吸入器。 对内部喷雾阀施加足以导致剂量释放的量的预加载，但是这通过施加气动阻力来防止。 吸入器包括释放装置，其在致动时释放抵抗力并允许预压力致动气溶胶阀。 然后释放计量剂量的药物以供患者吸入。 气动阻力由隔膜部分限定的负压区建立。 隔膜包括通过第二相对低刚度材料的挠曲而联接的第一相对高刚度材料和外围环的中心盘。

公开(公告)号：EP1436028A2

公开(公告)日：2004-07-14

申请号：EP02763585.3

申请日：2002-08-30

申请人： Ivax Corporation

发明人： BARNEY, Brian ,  CHEW, Sophia ,  FAIRBURN, Paul ,  O'LEARY, David ,  STRIEBIG, Rachel ,  STRIEBIG, Rachel

IPC分类号： A61M11/00 ,  A61M15/00 ,  A61M16/00 ,  B05B1/08

CPC分类号： A61M15/0028 ,  A61M15/0016 ,  A61M15/0018 ,  A61M15/0033 ,  A61M15/0085 ,  A61M16/208 ,  A61M2205/14

摘要： A medicament delivery system (10) comprises a nebulizer device (11), an open-faced mist chamber-defining element (12) having a tubular input/output port (31), a tubular inhalation port (15) connecting to the output port (31) of the mist chamber-defining element (12), and a sealed unit dose ampoule (14) adapted to fit within the mist chamber-defining element (12). The nebulizer device (11) includes an ultrasonic transducer (21) responsive to applied electrical energy to generate ultrasonic energy, an ultrasonic transmission horn (23) between an input energy surface (25) at an input end and an energy delivery surface (27) at an output end. The sealed unit dose ampoule (14) can be placed directly into the nebulizer device (11) and acts as both the dose cup and baffle, so that the chance of spillage of drug and the number of components to be cleaned are minimized. The unit dose ampoule (14) has a conical base (28) to allow ultrasonic energy conducted from the ultrasonic system to be concentrated at the base of the ampoule (14). The inhalation port (15) includes an inhalation valve (62) and an exhalation valve (64).

公开(公告)号：EP1198448A2

公开(公告)日：2002-04-24

申请号：EP00950379.8

申请日：2000-07-11

申请人： Ivax Corporation

发明人： JEKKEL, Antonia ,  AMBRUS, Gabor ,  ILKOY, Eva ,  HORVATH, Ildiko ,  KONYA, Attila ,  SZABO, Istvan, Mihaly ,  NAGY, Zsuzsanna ,  HORVATH, Gyula ,  MOZES, Julianna ,  BARTA, Istvan ,  SOMOGYI, Gyorgy ,  SALAT, Janos ,  BOROS, Sandor

IPC分类号： C07C69/74 ,  C07C61/12 ,  C07C67/02

CPC分类号： C12R1/29 ,  C12P7/42 ,  C12P17/06

摘要： The present invention relates to a new microbial process for the preparation of the compound of formula (I) from a compound of general formula (II) wherein R+ stands for an alkali metal or ammonium ion, by the submerged cultivation of the strain able to 6β-hydroxylate a compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the bioconversion, which comprises cultivating a strain of the genera Micromonospora able to 6β-hydroxylate a compound of the general formula (II), wherein R+ is as defined above, on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts at 25-32 °C, thereafter feeding the substrate to be transformed into the developed culture, then fermenting the substrate until the end of bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.