公开(公告)号：EP1656445A1

公开(公告)日：2006-05-17

申请号：EP04737535.7

申请日：2004-07-07

申请人： Flinders Technologies PTY. Ltd.

发明人： FRANCO, Christopher, Milton, Mathew ,  COOMBS, Justin, Taylor

IPC分类号： C12N1/20 ,  A61K35/74 ,  A01N63/02

CPC分类号： A01N63/04 ,  A01N63/00 ,  C12N1/20 ,  C12R1/01 ,  C12R1/29 ,  C12R1/465

摘要： The present invention relates to a method for improving plant productivity, and in particular crop yields, via the introduction of an endophytic microorganism to the subject plant. More particularly, the present invention is directed to a method for improving cereal crop productivity via the introduction of an endophytic actinomycete to the subject crop. The method of the present invention facilitates the improvement of crop productivity , such as increasing germination, by, inter alia, providing the subject plant with disease bio-control capabilities and up-regulating plant growth promoting activities. The present invention is also directed to novel endophytic microorganisms and uses thereof.

公开(公告)号：EP1198448A4

公开(公告)日：2003-05-28

申请号：EP00950379

申请日：2000-07-11

申请人： IVAX CORP

发明人： JEKKEL ANTONIA ,  AMBRUS GABOR ,  ILKOY EVA ,  HORVATH ILDIKO ,  KONYA ATTILA ,  SZABO ISTVAN MIHALY ,  NAGY ZSUZSANNA ,  HORVATH GYULA ,  MOZES JULIANNA ,  BARTA ISTVAN ,  SOMOGYI GYORGY ,  SALAT JANOS ,  BOROS SANDOR

IPC分类号： C12P7/62 ,  C07C69/30 ,  C12P1/04 ,  C12P7/42 ,  C12P17/06 ,  C12R1/29 ,  C12R1/31

CPC分类号： C12R1/29 ,  C12P7/42 ,  C12P17/06

摘要： The present invention relates to a new microbial process for the preparation of the compound of formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of the strain able to 6 beta -hydroxylate a compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the bioconversion, which comprises cultivating a strain of the genera Micromonospora able to 6 beta -hydroxylate a compound of the general formula (II), wherein R is as defined above, on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts at 25-32 DEG C, thereafter feeding the substrate to be transformed into the developed culture, then fermenting the substrate until the end of bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.

公开(公告)号：EP1097937A1

公开(公告)日：2001-05-09

申请号：EP00128100.5

申请日：1990-04-06

申请人： American Cyanamid Company

发明人： Lee, May Dean-Ming

IPC分类号： C07H15/203 ,  A61K31/704 ,  A61P31/04 ,  A61P35/00

CPC分类号： C07H15/203 ,  C12P19/60 ,  C12R1/29

摘要： The invention is N-acyl and dihydro-N-acyl analogs of the family of antibacterial and antitumor agents known collectively as the E33288 complex.

摘要翻译： 本发明是统称为E33288复合物的抗菌剂和抗肿瘤剂家族的N-酰基和二氢-N-酰基类似物。

公开(公告)号：EP0484856A2

公开(公告)日：1992-05-13

申请号：EP91118770.6

申请日：1991-11-04

申请人： Bristol-Myers Squibb Company

发明人： Saitoh, Kyoichiro ,  Miyaki, Takeo ,  Yamamoto, Haruaki ,  Oda, Nahomi

IPC分类号： C07D491/044 ,  C12P17/18 ,  A61K31/445

CPC分类号： C07D491/04 ,  C12P17/18 ,  C12R1/29

摘要： The novel antitumor antibiotic of formula (I) designated herein as dynemicin C is produced by fermentation of Micromonospora chersina M956-1 mutant F1085 (ATCC-55077). Dynemicin C and its triacetate derivative possess antibacterial and antifungal activity and also inhibit the growth of mammalian tumors.

摘要翻译： 本文命名为Dynemicin C的式（I）抗新药抗生素由Micromonospora chersina M956-1突变体F1085（ATCC-55077）的发酵产生。 Dynemicin C及其三醋酸酯衍生物具有抗菌和抗真菌活性，也抑制哺乳动物肿瘤的生长。

公开(公告)号：EP0392376A2

公开(公告)日：1990-10-17

申请号：EP90106601.9

申请日：1990-04-06

申请人： AMERICAN CYANAMID COMPANY

发明人： Lee, May Dean-Ming

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203 ,  C12P19/60 ,  C12R1/29

摘要： The invention is N-acyl and dihydro-N-acyl analogs of formula (I) of the family of antibacterial and antitumor agents known collectively as the E33288 complex.
wherein W is
R is hydrogen or a branched or unbranched alkyl (C₁-C₁₀) or alkylene (C₁-C₁₀) group, an aryl or hetero-aryl group, or an aryl-alkyl (C₁-C₅) or hetero-aryl-alkyl (C₁-C₅) group, all optionally substituted by one or more hydroxy, amino, carboxy, halo, nitro, lower (C₁-C₃) alkoxy, or lower (C₁-C₅) thioalkoxy groups; R₁ is H or
R₂ is CH₃, C₂H₅ or CH(CH₃)₂; R₄ is OH when R₅ is H or R₄ and R₅ taken together are a carbonyl; and X is an iodine or bromine atom.

摘要翻译： 本发明是共同称为E33288络合物的抗菌和抗肿瘤剂家族的式（I）的N-酰基和二氢-N-酰基类似物。 其中W是 R是氢或支链或非支链烷基（C1-C10）或亚烷基（C1-C10）基团，芳基或杂芳基或芳基 - 烷基（C1-C5） 或任选被一个或多个羟基，氨基，羧基，卤素，硝基，低级（C 1 -C 3）烷氧基或低级（C 1 -C 5）硫代烷氧基取代的杂芳基 - 烷基（C 1 -C 5） R1是H或CHEM，R2是CH3，C2H5或CH（CH3）2; 当R 5为H或R 4时，R 4为OH，R 5一起为羰基; X是碘或溴原子。

公开(公告)号：EP0133694B1

公开(公告)日：1990-07-25

申请号：EP84109221.6

申请日：1984-08-03

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： Uwajima, Takayuki ,  Aisaka, Kazuo

IPC分类号： C12N9/24 ,  C12Q1/34

CPC分类号： C12Y302/01018 ,  C12N9/24 ,  C12N9/2402 ,  C12Q1/34 ,  C12R1/29 ,  Y10S435/867 ,  Y10S435/868

摘要： Neuraminidase is produced by culturing a neuraminidase producing microorganism belonging to the genus Micromonospora. The neuraminidase is useful for the quantitative determination of a sialic acid-containing substance in a sample.

公开(公告)号：EP0353381A2

公开(公告)日：1990-02-07

申请号：EP89104428.1

申请日：1989-03-13

申请人： AMERICAN CYANAMID COMPANY

发明人： Carter, Guy Thomas ,  Goodman, Joseph Jacob ,  Labeda, David Paul

IPC分类号： C07D498/14 ,  C12P17/18 ,  C12N1/20 ,  A61K31/00

CPC分类号： C07D498/14 ,  C12P17/188 ,  C12R1/29

摘要： This disclosure describes a novel antibac­terial agent designated LL-E10985a, its production by aerobic fermentation of a new subspecies of Micromono­spora citrea NRRL 18351 mutants thereof, and the isolation and purification thereof.

摘要翻译： 本公开描述了一种名为LL-E10985a的新型抗菌剂，其通过需氧发酵其新的亚种小突状小孢子NRRL 18351突变体的产生，以及其分离和纯化。

公开(公告)号：EP0342341A2

公开(公告)日：1989-11-23

申请号：EP89105596.4

申请日：1989-03-30

申请人： AMERICAN CYANAMID COMPANY

发明人： McGahren, William James ,  Ellestad, George A.

IPC分类号： C07H15/203 ,  A61K31/70 ,  C12P19/62

CPC分类号： C07H15/207 ,  C07H15/22 ,  C12P19/56 ,  C12R1/29

摘要： This disclosure describes a novel aerobic fermentation process for producing the antitumor anti­biotics LL-E33288γ₂-Br and LL-E33288γ₂-I.

摘要翻译： 本公开描述了用于产生抗肿瘤抗生素LL-E33288γ2-Br和LL-E33288γ2 -I的新型好氧发酵方法。

公开(公告)号：EP0330874A2

公开(公告)日：1989-09-06

申请号：EP89102112.3

申请日：1989-02-08

申请人： AMERICAN CYANAMID COMPANY

发明人： McGahren, William James ,  Ellestad, George A.

IPC分类号： C07H17/00 ,  C12P1/06 ,  C12P19/64 ,  A61K35/66 ,  A61K31/00

CPC分类号： C12R1/29 ,  C07H17/00 ,  C12P1/06 ,  C12P19/60 ,  C12P19/64

摘要： Antibacterial and antitumor agents designated LL-E33288ε-I and LL-E33288ε-Br, their production by strains of Micromonospora echinospora ssp. calichensis designated NRRL-15839, NRRL-15975 and NRRL-18149, and chemical processes for their production, are disclosed. Novel intermediates prepared in the chemical processes are disclosed. Processes for producing reductively aromatized derivatives of other antibiotics are also disclosed.

摘要翻译： 名称为LL-E33288 epsilon-I和LL-E33288 epsilon-Br的抗菌剂和抗肿瘤剂，它们由小单孢菌属（Micomonospora echinospora）生产。 公开了指定为NRRL-15839，NRRL-15975和NRRL-18149的calichensis及其生产的化学方法。 公开了在化学过程中制备的新型中间体。 还公开了生产其它抗生素还原性芳构化衍生物的方法。

公开(公告)号：EP1542690A2

公开(公告)日：2005-06-22

申请号：EP03751830.5

申请日：2003-08-01

申请人： University of Maryland Biotechnology Institute ,  The University of Mississippi

发明人： HILL, Russell, T. ,  HAMANN, Mark, T. ,  PERAUD, Olivier ,  KASANAH, Noer

IPC分类号： A61K31/497 ,  C12N1/00 ,  C12N1/12 ,  C12N1/20 ,  C12P1/00 ,  C12P17/00

CPC分类号： C07D519/00 ,  C07K14/36 ,  C12P17/182 ,  C12P17/188 ,  C12R1/29

摘要： Disclosed are strains of actinomycetes that produce manzamines or derivatives thereof, methods of isolating said strains, and a 16S rRNA useful in identifying manzamine-producing bacteria.