公开(公告)号：EP3738603A1

公开(公告)日：2020-11-18

申请号：EP19738828.3

申请日：2019-01-11

申请人： The University of Tokyo ,  Japan as Represented by The Director-General of National Institute of Infectious Diseases

发明人： SUGA, Hiroaki ,  PASSIOURA, Toby ,  WAKITA, Takaji ,  WATASHI, Koichi

IPC分类号： A61K38/12 ,  A61P1/16 ,  A61P31/12 ,  A61P31/14 ,  A61P31/20 ,  A61P43/00 ,  C07K5/04 ,  C07K7/06 ,  C07K7/08

摘要： The present invention provides a sodium taurocholate cotransporting polypeptide (NTCP) inhibitor comprising a cyclic peptide having a Xw1-W-Xw2-W structure, wherein Xw1 and Xw2 are each independently T, S, I, L, or V, or a N-alkylamino acid thereof, or having a P-Xp1-Xp2-H structure, wherein Xp1 is any amino acid, and Xp2 is I, L, or V, or a N-alkylamino acid thereof, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP1930416B1

公开(公告)日：2011-12-14

申请号：EP06810937.0

申请日：2006-09-29

申请人： JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES ,  Tokyo Metropolitan Institute of Medical Science ,  TORAY INDUSTRIES, INC.

发明人： TANABE, Jun-ichi, c/o Pharmaceutical Research Laboratories ,  SONE, Saburo ,  WAKITA, Takaji, c/o Department of Virology II, National Institute ,  ISHII, Koji ,  SUZUKI, Ryosuke ,  SUZUKI, Tetsuro ,  MIYAMURA, Tatsuo

IPC分类号： C12N7/00 ,  C12N15/09 ,  C12N7/04

CPC分类号： C12N7/00 ,  C12N15/86 ,  C12N2770/24223 ,  C12N2770/24243 ,  C12N2770/24252

摘要： The invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising introducing into (i) a cell which autonomously replicates an RNA replicon including a base sequence encoding a 5’ noncoding region, NS3 protein, NS4A protein, NS4B protein, NS5A protein and NS5B protein in the genomic RNA derived from a hepatitis C virus strain and a base sequence including a 3’ noncoding region, (ii) a vector expressing Core protein, E1 protein, E2 protein and p7 protein derived from the same or a different hepatitis C virus strain in (i), culturing the cell and collecting the produced virus-like particle and a recombinant hepatitis C virus particle produced by the method.