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11.发明公开COMPOSITIONS WITH ANTI-APOPTOTIC ACTIVITY, CONTAINING A MIXTURE OF PHOSPHOLIPIDS 失效抗凋亡组合物的磷脂中的一个混合物中含有
公开(公告)号：EP0850064A1
公开(公告)日：1998-07-01
申请号：EP96931580.0
申请日：1996-09-13
CPC分类号： A61K31/685 , A61K9/127 , A61K31/66 , Y10S514/844 , Y10S514/863 , Y10S514/88 , A61K2300/00
摘要： The present invention provides compositions with anti-apoptotic activity comprising phosphatidic acid, phosphatidylinositol, lysophosphatidic acid, lysophosphatidylinositol and lysophosphatidylcholine.
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12.发明公开METHODS OF SCREENING FOR THERAPEUTIC AGENTS USING NOVEL APOPTOSIS-MODULATING PROTEINS 失效一种筛选使用新的细胞凋亡调节蛋白的治疗剂
公开(公告)号：EP0821793A1
公开(公告)日：1998-02-04
申请号：EP96913062.0
申请日：1996-04-19
CPC分类号： G01N33/6845 , C07K14/4747 , C07K14/82 , G01N33/68
摘要： The present invention provides methods to screen for anti-viral agents utilizing a novel family of apoptosis-modulating proteins.
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13.发明公开A NOVEL FAMILY OF POLLEN PROTEINASES, METHODS OF USE THEREOF AND COMPOSITIONS DERIVED THEREFROM 失效POLLENPROTEINASEN新系列，其使用方法和衍生组合
公开(公告)号：EP0705435A4
公开(公告)日：1997-11-26
申请号：EP94921321
申请日：1994-06-17
发明人： TRAVIS JAMES , BARR PHILIP J
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14.发明公开METHODS OF IDENTIFYING POTENTIALLY THERAPEUTICALLY EFFECTIVE AGENTS AND CELL STRAINS FOR USE THEREIN 失效方法能够识别潜在的治疗性的有效手段及适宜达尔富尔细胞系
公开(公告)号：EP0703990A4
公开(公告)日：1997-09-24
申请号：EP94916006
申请日：1994-04-29
发明人： TOMEI L DAVID
CPC分类号： G01N33/5011 , C12N5/0693 , C12N2500/20 , C12N2503/02 , G01N33/5008 , G01N33/5014 , G01N33/5017 , G01N2500/10 , G01N2510/00
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15.发明公开COMPOSITIONS WHICH INHIBIT APOPTOSIS, METHODS OF PURIFYING THE COMPOSITIONS AND USES THEREOF 失效组合物，它可以防止细胞凋亡，方法清洗这种组合物及其用途
公开(公告)号：EP0732930A1
公开(公告)日：1996-09-25
申请号：EP95903617.0
申请日：1994-11-30
IPC分类号： A61K , A61K8 , A01N1 , A61K36 , A61K47 , A61P1 , A61P9 , A61P17 , A61P25 , A61P37 , A61P43 , C12N5
CPC分类号： A61K36/48 , A61K8/97 , A61K35/20 , A61Q19/08 , A61K2300/00
摘要： The present invention is directed to methods of obtaining plant-derived delipidated extracts that inhibit apoptosis, the extracts obtained, compositions containing said extracts and methods of using said compositions. The figure is a bar graph which illustrates a lower incidence of diarrhea in rats treated with methotrexate and fed a diet of compositions of the claimed invention as compared to controls.
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16.发明公开COMPOSITIONS CONTAINING LYSOPHOSPHATIDIC ACIDS WHICH INHIBIT APOPTOSIS AND USES THEREOF 审中-公开设置LYSOPHOSPHATIDYLSÄURE含有抑制细胞凋亡及其用途
公开(公告)号：EP1069895A2
公开(公告)日：2001-01-24
申请号：EP99913956.1
申请日：1999-03-17
发明人： GODDARD, John, G. , PICKER, Donald, H. , UMANSKY, Samuil, R. , PRICE, Steven , WIJKMANS, Jacobus, C., H., M. , BOYD, Edward, Andrew , BAXTER, Anthony, David
IPC分类号： A61K31/255 , A61K31/66 , C07F9/09 , C07C305/10 , C07C305/06
CPC分类号： A61K31/66
摘要： The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.
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公开(公告)号：EP0973384A1
公开(公告)日：2000-01-26
申请号：EP98907460.4
申请日：1998-02-12
IPC分类号： A01N1/02
CPC分类号： A01N1/0221 , A01N1/02 , A01N1/0226
摘要： A composition comprising a storage-stable organ preservation solution, comprising a linear polyethylene glycol having an average molecular weight of approximately 20,000 Daltons and being essentially free of decomposition products. This solution can be used for organ preservation as a perfusate in a process in which the perfusate if flowed through the circulatory system of the organ, and can also be used for transplantation or routine open heart cardioplegic applications.
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18.发明公开
公开(公告)号：EP0932678A2
公开(公告)日：1999-08-04
申请号：EP97945277.0
申请日：1997-09-24
发明人： UMANSKY, Samuil , MELKONYAN, Hovsep
IPC分类号： G01N33 , A61K31 , A61K38 , A61K39 , A61K48 , A61P35 , A61P43 , C07K14 , C07K16 , C12N1 , C12N5 , C12N15 , C12P21
CPC分类号： C07K14/4747 , A61K38/00 , C07K2319/00
摘要： An isolated polynucleotide at leat 60 % homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids of αSARP polypeptide; a host cell transformed with an isolated polynucleotide or vector; antibodies specific for SARP and use of such polynucleotides and antibodies in diagnostic and therapeutic method. Therapeutic uses of antibodies and polynucleotides of sarp. Methods for treating diseases related to the regulation of SARP expression in tissue and bodily fluid samples, including cancers.
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公开(公告)号：EP0729300A4
公开(公告)日：1998-08-05
申请号：EP95901253
申请日：1994-11-15
发明人： BARR PHILIP J , SHAPIRO JOHN P , KIEFER MICHAEL C
IPC分类号： A01K67/027 , A61K31/70 , A61K38/00 , A61K39/395 , A61K48/00 , A61P17/00 , A61P35/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , G01N33/53 , A01N43/04 , A61K35/16 , A61K39/00 , C07H17/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K16/00 , C12N1/00
CPC分类号： A61K31/711 , A61K38/00 , C07K14/70578 , C07K14/715 , C07K16/2878 , C12N2799/026
摘要： The invention provides soluble forms of the Fas (Apo-1 ) protein comprising both the intracellular and extracellular domains of the full-length polypeptide. Exemplified is a naturally-occurring splice variant of the Fas gene, Fas DELTA TM, which lacks the transmembrane domain of the native antigen. DNA encoding the protein, cells expressing the recombinant DNA, and methods of using the protein and DNA are also provided.
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20.发明公开NOVEL APOPTOSIS-MODULATING PROTEINS, DNA ENCODING THE PROTEINS AND METHODS OF USE THEREOF 失效凋亡调节蛋白，YOU编码中使用的DNA和方法
公开(公告)号：EP0731636A4
公开(公告)日：1998-04-15
申请号：EP95904808
申请日：1994-11-30
发明人： KIEFER MICHAEL C , BARR PHILIP J
IPC分类号： A01K67/027 , A61K38/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/13 , C12N15/85 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , A01N43/04 , A01N63/00 , A61K31/70 , C07K16/00 , C12N1/08 , C12N1/21 , C12N5/00 , C12N5/06 , C12N5/16
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A61K38/00 , C07K14/4747 , C12Q1/6876 , C12Q2600/158
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